Draft - work in progress
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- Ficaria verna Huds. // Ficaria ranunculoides Roth // Ranunculus ficaria L.
Ficaria verna Huds. // Ficaria ranunculoides Roth // Ranunculus ficaria L.
- Family:
- Ranunculaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 251
- Number of processed references:
- 5
Composition #1: Pourrat, A., Pourrat, H. Pilewort, Ficaria ranunculoides. plantes medicinales et phytotherapie, 1969, p. 288–295. .
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Substance:
Saponins (RF-00004333-PAR)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
2.0-2.5
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Internal remarks:
Saponins
Composition #2: Bonora, A., Botta, B., Menziani-Andreoli, E., Bruni, A. Organ-specific distribution and accumulation of protoanemonin in Ranunculus ficaria L. biochemie und physiologie der pflanzen, 1988, p. 451–455. .
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Plant part:
Live plants (as part-nature) (A0BA0)
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Extraction/Preparation method:
Essential oil (as part-nature) (A166Q)
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Substance:
Protoanemonin (RF-00003593-PAR)
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Result unit:
Milligram/gram (G060A)
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Result expression:
Whole weight (B001A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
1.48
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Internal remarks:
Protoanemonin
Composition #3: Marston, Andrew., Cabo, Martine., Lubrano, Christian., Robin, Jean-Renaud., Fromageot, Claude., Hostettmann, Kurt. Clarification of the saponin composition of ranunculus ficaria tubers. natural product communications, 2006, vol. 1, no. 1, p. 27–32. .
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Additional extraction description:
unspecified
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Substance:
Saponins (RF-00004333-PAR)
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Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Saponins
Composition #4: TEXIER, O., AHOND, A., REGERAT, F., POURRAT, H. A TRITERPENOID SAPONIN FROM FICARIA-RANUNCULOIDES TUBERS. phytochemistry, 1984, vol. 23, no. 12, p. 2903–2905. DOI: 10.1016/0031-9422(84)83038-1.
[
DOI link]
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Plant part:
Roots and other underground parts used as staple food (as part-nature) (A0F5F)
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Additional extraction description:
unspecified
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Substance:
pentacyclic triterpene saponins (RF-00004334-PAR)
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Additional substance description:
3-O-(r-arabinopyranosyl- 1’)28-O-[b-glucopyranosyl- 1”” --t 6” (a-rhamnopyranosyl- 1 ‘I’ -+ 4”) fl-glucopyranosyl- 1 “I-hederagenin.
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Analytical method code:
Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
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Analytical method - additional description:
C and H NMR, UV, IR, MS
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Pentacyclic triterpene saponin
Endpoint study
#1: Yilmaz, Bulent., Yilmaz, Baris., Aktas, Bora., Unlu, Ozan., Roach, Emir Charles. Lesser celandine (pilewort) induced acute toxic liver injury: The first case report worldwide. . world journal of hepatology, 2015, vol. 7, no. 2, p. 285–8. DOI: 10.4254/wjh.v7.i2.285.
[
DOI link]
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Study relevance:
Human health
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Plant part:
Unspecified (A07XD)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
infusion
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Type of toxicological test:
case report (CHD060TT)
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Tested organism:
Human (as organism) (A056J)
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Route of exposure:
ORAL: DRINKING WATER (OECD2229PL)
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Unit of exposure duration:
Day (G134A)
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Number of organisms dosed:
1
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Endpoint measured:
Dose level (CHD014EP)
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Concentration unit:
Unit (G005A)
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Critical effect:
HEPATOTOXICITY (TOX02A)
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Target tissue:
digestive: Liver (TT023A)
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Effect description:
consumption of 1 cup per day for 3 days led to acute hepatitis; jaundice on her sclera.
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Effect or parameter linked to the endpoint:
histopathology non neoplastic (CHD025BE)
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Internal remarks:
hepatotoxicity
