EFSA Compendium of Botanicals

Draft - work in progress

Ferula gummosa Boiss. // Ferula galbaniflua Boiss. & Bushe

Family:: Apiaceae (Umbelliferae)
Approval state:: Approved
Number of articles retrieved:: 165
Number of processed references:: 7

Compositions

#1: Alkaloids #2: Sesquiterpene coumarins in fruit #3: Alkaloids #4: beta-myrcene #5: Coumarins #6: Sesquiterpene coumarins

Endpoint Studies

#1: cardio vascular adverse effect

Genotoxicity

Composition #1: Sayyah, M., Mandgary, A. Anticonvulsant effect of Ferula gummosa root extract against experimental seizures. Iranian Biomedical Journal, 2003, vol. 7, no. 3, p. 139–143. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acetone
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids

Composition #2: Iranshahi, Mehrdad., Barthomeuf, Chantal., Bayet-Robert, Mathilde., Chollet, Philippe., Davoodi, Davood., Piacente, Sonia., Rezaee, Ramin., Sahebkar, Amirhossein. Drimane-Type Sesquiterpene Coumarins from Ferula gummosa Fruits Enhance Doxorubicin Uptake in Doxorubicin-Resistant Human Breast Cancer Cell Line.. Journal of traditional and complementary medicine, 2014, vol. 4, no. 2, p. 118–25. DOI: 10.4103/2225-4110.126181. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

petroleum ether and dichloromethane
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

Sesquiterpene coumarins: conferone, mogoltacin, and feselol
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

column chromatography
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Sesquiterpene coumarins in fruit

Composition #3: Sayyah, M., Mandgary, A., Kamalinejad, M. Evaluation of the anticonvulsant activity of the seed acetone extract of Ferula gummosa Boiss. against seizures induced by pentylenetetrazole and electroconvulsive shock in mice. JOURNAL OF ETHNOPHARMACOLOGY, 2002, vol. 82, no. 2-3, p. 105–109. DOI: 10.1016/S0378-8741(02)00166-6. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acetone
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids

Composition #4: Ghannadi, A., Amree, S. Volatile oil constituents of Ferula gummosa Boiss. from Kashan, Iran. JOURNAL OF ESSENTIAL OIL RESEARCH, 2002, vol. 14, no. 6, p. 420–421. .

Language:

English (en)
Extraction/Preparation method:

Latex (as part-nature) (A166S)
Additional extraction description:

hydrodistillation of the fresh oleogum resin and latex for 3 h
Substance:

myrcene (RF-00003503-PAR)
Additional substance description:

beta-myrcene
Analytical method code:

Gaschromatography (GC) (F037A)
Analytical method - additional description:

GC and GC-MS
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

4.6
Internal remarks:

beta-myrcene

Composition #5: Adhami, Hamid-Reza., Fitz, Veronika., Lubich, Andrea., Kaehlig, Hanspeter., Zehl, Martin., Krenn, Liselotte. Acetylcholinesterase inhibitors from galbanum, the oleo gum-resin of Ferula gummosa Boiss.. PHYTOCHEMISTRY LETTERS, 2014, vol. 10, p. LXXXII–lxxxvii. DOI: 10.1016/j.phytol.2014.08.023. [DOI link]

Language:

English (en)
Extraction/Preparation method:

Oleo-gum-resin (as part-nature) (A166T)
Additional extraction description:

dichloromethane extract
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

deacetylkellerin, farnesiferol B, kellerin, umbelliferone, auraptene and derivatives
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

column chromatography
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

22.22
Internal remarks:

Coumarins

Composition #6: Kasaian, Jamal., Mosaffa, Fatemeh., Behravan, Javad., Masullo, Milena., Piacente, Sonia., Ghandadi, Morteza., Iranshahi, Mehrdad. Reversal of P-glycoprotein-mediated multidrug resistance in MCF-7/Adr cancer cells by sesquiterpene coumarins. FITOTERAPIA, 2015, vol. 103, p. 149–154. DOI: 10.1016/j.fitote.2015.03.025. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Chloroform extract
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

sesquiterpene coumarins: Farnesiferol A, conferone, conferdione, feselol and gumoside B
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Sesquiterpene coumarins

Endpoint study #1: Ghorbani, Ahmad., Mohebbati, Reza., Jafarian, Amir Hossein., Vahedi, Mohammad Mandi., Hosseini, Seyed Mahmoud., Soukhtanloo, Mohammad., Sadeghnia, Hamid Reza., Hosseini, Azar. Toxicity evaluation of hydroalcoholic extract of Ferula gummosa root. REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2016, vol. 77, p. 35–41. DOI: 10.1016/j.yrtph.2016.02.008. [DOI link]

Study relevance:

Human health
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

ethanol 70% extract
Type of toxicological test:

short-term toxicity (CHD017TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Wistar (CHD013ST)
Sex:

Male
Route of exposure:

ORAL: FEED (OECD2230PL)
Exposure duration:

28.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

10
Control groups used:

yes
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligram/kilogram (G061A)
Effect concentration:

600
Critical effect:

PULMONARY AND CARDIAC (TOX08A)
Target tissue:

cardiovascular / haematological: Heart (TT011A)
Effect description:

slightly increased heart rate from 333.0±6.6 bpm (control) to 357.0 ± 14.6 bpm; increased systolic blood pressure from 133.0 ± 4.2 mmHg to 173.0±5.2 181 mmHg
Effect or parameter linked to the endpoint:

no data (CHD002BE)
Internal remarks:

cardio vascular adverse effect