EFSA Compendium of Botanicals

Draft - work in progress

Ferula elaeochytris Korovin

Family:: Apiaceae
Approval state:: Approved
Number of articles retrieved:: 8
Number of processed references:: 4

Compositions

#1: Acetylmethyl salicylate #2: Ferulasaponin (saponin) #3: Sandrosaponin IX in root #4: 6-(phydroxybenzoyl)epoxyjaeschkcanadiol in roots

Endpoint Studies

#1: infertility in males, hatching depressed

Genotoxicity

Composition #1: Miski, Mahmut., Ulubelen, Ayhan., Mabry, Tom J. Six sesquiterpene alcohol esters from Ferula elaeochytris. Phytochemistry (Elsevier), 1983, p. 2231-2233.

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

benzen, chloroform and ethanol
Substance:

methyl salicylate (RF-00003930-PAR)
Additional substance description:

Acetylmethyl salicylate
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Acetylmethyl salicylate

Composition #2: Al Khatib, R., Hennebelle, T., Joha, S., Idziorek, T., Preudhomme, C., Quesnel, B., Sahpaz, S., Bailleul, F. New sesquiterpene esters and a saponin from Ferula elaeochytris and their cytotoxic evaluation against leukemia cell lines. PLANTA MEDICA, 2008, vol. 74, no. 9, p. 1030-1031.

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Saponins (RF-00004333-PAR)
Additional substance description:

Ferulasaponin
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Ferulasaponin (saponin)

Composition #3: Alkhatib, Racha., Hennebelle, Thierry., Joha, Sami., Idziorek, Thierry., Preudhomme, Claude., Quesnel, Bruno., Sahpaz, Sevser., Bailleul, Francois. Activity of elaeochytrin A from Ferula elaeochytris on leukemia cell lines . phytochemistry, 2008, vol. 69, no. 17, p. 2979–2983. DOI: 10.1016/j.phytochem.2008.09.019. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

Saponins (RF-00004333-PAR)
Additional substance description:

Sandrosaponin IX
Analytical method code:

Mass Spectroscopy and hyphenated methods without chromatography (F063A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Sandrosaponin IX in root

Composition #4: Alkhatib, Racha., Hennebelle, Thierry., Joha, Sami., Idziorek, Thierry., Preudhomme, Claude., Quesnel, Bruno., Sahpaz, Sevser., Bailleul, Francois. Activity of elaeochytrin A from Ferula elaeochytris on leukemia cell lines . phytochemistry, 2008, vol. 69, no. 17, p. 2979–2983. DOI: 10.1016/j.phytochem.2008.09.019. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

epoxides (RF-00010829-PAR)
Additional substance description:

6-(phydroxybenzoyl)epoxyjaeschkcanadiol
Analytical method code:

Mass Spectroscopy and hyphenated methods without chromatography (F063A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

6-(phydroxybenzoyl)epoxyjaeschkcanadiol in roots

Endpoint study #1: Canogullari, Sibel., Baylan, M., Copur, Gulsen., Sahin, A. Effects of dietary Ferula elaeochytris root powder on the growth and reproductive performance of Japanese quail (Coturnix coturnix japonica): it is not recommended in a breeder diet. ARCHIV FUR GEFLUGELKUNDE, 2009, vol. 73, no. 1, p. 56-60.

Study relevance:

Animal (target species) health
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Preparation/Extraction method:

Powder (A06JD)
Type of toxicological test:

reproduction toxicity (CHD009TT)
Tested organism:

Japanese Quail (as animal) (A0CNJ)
Sex:

Male
Route of exposure:

ORAL: FEED (OECD2230PL)
Exposure duration:

5.0
Unit of exposure duration:

Week (G205A)
Control groups used:

yes
Endpoint measured:

Concentration level (CHD013EP)
Concentration unit:

Gram/kilogram (G015A)
Effect concentration:

5-10
Critical effect:

REPRODUCTIVE (TOX05A)
Effect description:

infertility in males, hatching depressed
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

infertility in males, hatching depressed