Draft - work in progress
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- Asafetida (as plant) // Ferula assa-foetida L.
Asafetida (as plant) // Ferula assa-foetida L.
- Family:
- Apiaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 236
- Number of processed references:
- 4
Composition #1: Banerji, A., Mallick, B., Chatterjee, A., Budzikiewicz, H., Breuer, M. Assafoetidin and ferocolicin, two sesquiterpenoid coumarins from Ferula assafoetida Regel. Tetrahedron Letters, 1988, p. 1557–1560. .
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Plant part:
Live plants (as part-nature) (A0BA0)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Ether
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Substance:
coumarins (RF-00004351-PAR)
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Additional substance description:
ferocolicin
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Analytical method code:
Chromatographic tests (F015A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
ferocolicin
Composition #2: Banerji, A., Mallick, B., Chatterjee, A., Budzikiewicz, H., Breuer, M. Assafoetidin and ferocolicin, two sesquiterpenoid coumarins from Ferula assafoetida Regel. Tetrahedron Letters, 1988, p. 1557–1560. .
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Plant part:
Live plants (as part-nature) (A0BA0)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Ether
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Substance:
coumarins (RF-00004351-PAR)
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Additional substance description:
assafoetidin
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Analytical method code:
Chromatographic tests (F015A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
assafoetidin
Composition #3: Nassar, M. I., Abu-Mustafa, E. A., Ahmed, A. A. Sesquiterpene coumarins from Ferula assafoetida L. pharmazie, 1995, p. 766–767. .
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Substance:
umbelliprenin (RF-00003616-PAR)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
umbelliprenin
Composition #4: Nassar, M. I., Abu-Mustafa, E. A., Ahmed, A. A. Sesquiterpene coumarins from Ferula assafoetida L. pharmazie, 1995, p. 766–767. .
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Substance:
Gummosin (RF-00010981-PAR)
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Additional substance description:
Gummosin
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Gummosin
Composition #5: Asghari J., Atabaki V., Baher E., Mazaheritehrani M. Identification of sesquiterpene coumarins of oleo-gum resin of Ferula assa-foetida L. from the Yasuj region. Natural product research, 2015, p. 1–4. .
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Chloroform
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Substance:
coumarins (RF-00004351-PAR)
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Additional substance description:
badrakemin, feslol, isosamarcandin, samarcandin
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Analytical method code:
Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
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Analytical method - additional description:
1D (H and C) and 2D NMR (HMBC, HSQC and NOESY)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Coumarins
Composition #6: Asghari J., Atabaki V., Baher E., Mazaheritehrani M. Identification of sesquiterpene coumarins of oleo-gum resin of Ferula assa-foetida L. from the Yasuj region. Natural product research, 2015, p. 1–4. .
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Chloroform
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Substance:
conferone (RF-00011370-PAR)
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Analytical method code:
Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
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Analytical method - additional description:
1D (H and C) and 2D NMR (HMBC, HSQC and NOESY)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
conferone
Endpoint study
#1: Goudah, A., Abo-El-Sooud, K., Yousef, M.A. Acute and subchronic toxicity assessment model of Ferula assa-foetida gum in rodents. Veterinary World, 2015, vol. 8, no. 5, p. 584–589. DOI: 10.14202/vetworld.2015.584-589.
[
DOI link]
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Study relevance:
Human health
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Preparation/Extraction method:
Oleo-gum-resin (as part-nature) (A166T)
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Type of toxicological test:
short-term toxicity (CHD017TT)
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Tested organism:
Rat (as animal) (A0CNV)
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Strain of test organism:
Sprague-Dawley (CHD012ST)
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Route of exposure:
ORAL: GAVAGE (OECD2231PL)
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Unit of exposure duration:
Day (G134A)
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Number of organisms dosed:
10
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Endpoint measured:
Dose level (CHD014EP)
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Concentration unit:
Milligram/kilogram (G061A)
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Effect concentration:
250
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Critical effect:
HEPATOTOXICITY (TOX02A)
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Target tissue:
digestive: Liver (TT023A)
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Effect description:
mild changes as thrombosis and sinusoidal leukocytosis; portal infiltration with inflammatory cells
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Effect or parameter linked to the endpoint:
histopathology non neoplastic (CHD025BE)
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Internal remarks:
Mild hepatotoxicity
Endpoint study
#2: Goudah, A., Abo-El-Sooud, K., Yousef, M.A. Acute and subchronic toxicity assessment model of Ferula assa-foetida gum in rodents. Veterinary World, 2015, vol. 8, no. 5, p. 584–589. DOI: 10.14202/vetworld.2015.584-589.
[
DOI link]
-
Study relevance:
Human health
-
Preparation/Extraction method:
Oleo-gum-resin (as part-nature) (A166T)
-
Type of toxicological test:
short-term toxicity (CHD017TT)
-
Tested organism:
Rat (as animal) (A0CNV)
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Strain of test organism:
Sprague-Dawley (CHD012ST)
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Route of exposure:
ORAL: GAVAGE (OECD2231PL)
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Unit of exposure duration:
Day (G134A)
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Number of organisms dosed:
10
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Endpoint measured:
Dose level (CHD014EP)
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Concentration unit:
Milligram/kilogram (G061A)
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Effect concentration:
250
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Critical effect:
NEPHROTOXICITY (TOX03A)
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Target tissue:
urogenital: Kidneys (TT046A)
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Effect description:
Atrophy of glomerular tuft, thickening of parietal layer of Bowman capsule, and focal tubular necrosis; dilatation and congestion of renal blood vessels
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Effect or parameter linked to the endpoint:
histopathology non neoplastic (CHD025BE)
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Internal remarks:
Nephrotoxicity
