EFSA Compendium of Botanicals

Draft - work in progress

Farfugium japonicum (L.) Kitam

Family:: Asteraceae
Approval state:: Approved
Number of articles retrieved:: 110
Number of processed references:: 8

Compositions

#1: Furanoeremophilane derivatives #2: Eremofarfugin A and eremopetasitenin B3 #3: Sesquiterpene lactones and derivatives #4: Furanoeremophilane #5: Senkirkine #6: Farfugin A and B #7: Farfugine #8: Petasitenine

Endpoint Studies

#1: liver tumors

Genotoxicity

Composition #1: Nagano, Hajime., Tanahashi, Yoshiaki., Moriyama, Yoshihiko., Takahashi, Takeyoshi. New furanoeremophilane derivatives from Farfugium japonicum. bulletin of the chemical society of japan, 1973, p. 2840–2845. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ether
Substance:

furan derivatives (RF-00004396-PAR)
Additional substance description:

Furanoeremophilane derivatives
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Furanoeremophilane derivatives

Composition #2: Tori, M., Shiotani, Y., Tanaka, M., Nakashima, K., Sono, M. Eremofarfugin A and eremopetasitenin B-3, two new eremophilanolides from Farfugium japonicum. TETRAHEDRON LETTERS, 2000, vol. 41, no. 11, p. 1797–1799. DOI: 10.1016/S0040-4039(00)00032-0. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol extraction
Substance:

Sesquiterpene lactones (RF-00004319-PAR)
Additional substance description:

Eremofarfugin A and eremopetasitenin B3
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

spectroscopic techniques
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Eremofarfugin A and eremopetasitenin B3

Composition #3: Tori, Motoo., Otose, Kanako., Fukuyama, Hiroko., Murata, Junko., Shiotani, Yasuko., Takaoka, Shigeru., Nakashima, Katsuyuki., Sono, Masakazu., Tanaka, Masami. New eremophilanes from Farfugium japonicum. tetrahedron, 2010, vol. 66, no. 27-28, p. 5235–5243. DOI: 10.1016/j.tet.2010.04.079. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Sesquiterpene lactones (RF-00004319-PAR)
Additional substance description:

Sesquiterpene lactones and derivatives
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Sesquiterpene lactones and derivatives

Composition #4: Tori, Motoo., Otose, Kanako., Fukuyama, Hiroko., Murata, Junko., Shiotani, Yasuko., Takaoka, Shigeru., Nakashima, Katsuyuki., Sono, Masakazu., Tanaka, Masami. New eremophilanes from Farfugium japonicum. tetrahedron, 2010, vol. 66, no. 27-28, p. 5235–5243. DOI: 10.1016/j.tet.2010.04.079. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

furan derivatives (RF-00004396-PAR)
Additional substance description:

Furanoeremophilane
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Furanoeremophilane

Composition #5: Zhou, Jue., Ouedraogo, Moustapha., Qu, Fan., Duez, Pierre. Potential Genotoxicity of Traditional Chinese Medicinal Plants and Phytochemicals: An Overview. PHYTOTHERAPY RESEARCH, 2013, vol. 27, no. 12, p. 1745–1755. DOI: 10.1002/ptr.4942. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Additional extraction description:

unspecified
Substance:

Senkirkine (RF-00000300-TOX)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Senkirkine

Composition #6: NAGANO, H., MORIYAMA, Y., SATO, K., TAKAHASH.T., TANAHASH.Y., FUKUYAMA, M. FARFUGIN A AND B, NEW SESQUITERPENES FROM FARFUGIUM-JAPONICUM. chemistry letters, 1972, no. 1, p. 13–+. DOI: 10.1246/cl.1972.13. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

benzene
Substance:

Farfugine (RF-00000280-TOX)
Additional substance description:

Farfugin A and B
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

spectroscopic techniques: NMR, IR, MS, UV
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Farfugin A and B

Composition #7: NIWA, H., ISHIWATA, H., KURODA, A., YAMADA, K. FARFUGINE, A NEW PYRROLIZIDINE ALKALOID ISOLATED FROM FARFUGIUM-JAPONICUM KITAM. CHEMISTRY LETTERS, 1983, no. 5, p. 789–790. DOI: 10.1246/cl.1983.789. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol extraction
Substance:

Farfugine (RF-00000280-TOX)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

spectroscopic techniques: NMR, IR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Farfugine

Composition #8: NIWA, H., ISHIWATA, H., YAMADA, K. ISOLATION OF PETASITENINE, A CARCINOGENIC PYRROLIZIDINE ALKALOID FROM FARFUGIUM-JAPONICUM. JOURNAL OF NATURAL PRODUCTS, 1985, vol. 48, no. 6, p. 1003–1004. DOI: 10.1021/np50042a031. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol extraction
Substance:

Petasitenine (RF-00000293-TOX)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

spectroscopic techniques: NMR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Petasitenine

Endpoint study #1: HIRONO, I., UENO, I., AISO, S., YAMAJI, T., HAGA, M. CARCINOGENIC ACTIVITY OF FARFUGIUM-JAPONICUM AND SENECIO-CANNABIFOLIUS. CANCER LETTERS, 1983, vol. 20, no. 2, p. 191–198. DOI: 10.1016/0304-3835(83)90048-4. [DOI link]

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Additional plant/substance description:

The fresh leaves and stalks were dried in the shade, milled and mixed with rat basal diet CE-2
Type of toxicological test:

chronic/long term toxicity (CHD004TT)
Tested organism:

Rat (as animal) (A0CNV)
Sex:

Male/Female
Route of exposure:

ORAL: FEED (OECD2230PL)
Exposure duration:

480.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

15
Control groups used:

yes, plain diet
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Percent (G138A)
Effect concentration:

20
Critical effect:

HEPATOTOXICITY (TOX02A)
Target tissue:

digestive: Liver (TT023A)
Effect description:

hemangioendothelial sarcoma of the liver
Effect or parameter linked to the endpoint:

Carcinogenic (CHD036BE)
Internal remarks:

liver tumors