EFSA Compendium of Botanicals

Draft - work in progress

Euphorbia resinifera Berg

Family:: Euphorbiaceae
Approval state:: Approved
Number of articles retrieved:: 83
Number of processed references:: 4

Compositions

#1: Diterpene esters #2: Phorbol esters #3: resiniferatoxin #4: ingenol esters (ingenol)

Endpoint Studies

Genotoxicity

Composition #1: Hergenhahn, M., Kusumoto, S., Hecker, E. Diterpene esters from Euphorbium and their irritant and cocarcinogenic activity. Experientia, 1974, p. 1438–1440. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Latex (as part-nature) (A166S)
Substance:

Diterpene esters (RF-00010831-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Diterpene esters

Composition #2: Kreher, B., Neszmelyi, A., Jurcic, K., Wagner, H. New phytochemical and immunological investigations of Euphorbia resinifera and Daphne mezereum. planta medica, 1990, vol. 56, no. 6, p. 572–573. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Latex (as part-nature) (A166S)
Substance:

Phorbol esters (RF-00004310-PAR)
Additional substance description:

12-deoxyphorbol esters
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Phorbol esters

Composition #3: Fattorusso, E., Lanzotti, V., Taglialatela-Scafati, O., Tron, GC., Appendino, G. Bisnorsesquiterpenoids from Euphorbia resinifera Berg. and an expeditious procedure to obtain resiniferatoxin from its fresh latex. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2002, no. 1, p. 71–78. DOI: 10.1002/1099-0690(20021)2002:1<71::AID-EJOC71>3.0.CO;2-C. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Latex (as part-nature) (A166S)
Substance:

daphnane diterpenes (RF-00004330-PAR)
Additional substance description:

resiniferatoxin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

optical rotation, UV, IR, NMR, MS, CD
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

resiniferatoxin

Composition #4: GIRIN, MA., PAPHASSARANG, S., DAVIDETEVE, C., CHABOUD, A., RAYNAUD, J. DETERMINATION OF INGENOL IN HOMEOPATHIC MOTHER TINCTURES OF EUPHORBIA SPECIES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY. JOURNAL OF CHROMATOGRAPHY, 1993, vol. 637, no. 2, p. 206–208. DOI: 10.1016/0021-9673(93)83215-E. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Latex (as part-nature) (A166S)
Additional extraction description:

polar phase after hexane extraction
Substance:

ingenol esters ingenol esters (RF-00004358-PAR)
Additional substance description:

ingenol
Analytical method code:

HPLC-UV (F021A)
Result unit:

Microgram/millilitre (G052A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

16.71
Internal remarks:

ingenol esters (ingenol)