EFSA Compendium of Botanicals

Draft - work in progress

Euphorbia lactea Haw.

Family:: Euphorbiaceae
Approval state:: Approved
Number of articles retrieved:: 27
Number of processed references:: 3

Compositions

#1: diterpen ketons ingol type #2: Tinyatoxin #3: lectins

Endpoint Studies

Genotoxicity

#1: application of ear of mouse, irritation and tumor shift in 24 weeks, acetone extract of latex

Composition #1: Upadhyay, Rajiv R., Hecker, Erich. Diterpene esters of the irritant and cocarcinogenic latex of Euphorbia lactea. Phytochemistry (Elsevier), 1975, p. 2514–2516. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Latex (as part-nature) (A166S)
Additional extraction description:

aceton ectract of latex with cocarcinogenic activity
Substance:

Diterpene ketones (RF-00010828-PAR)
Additional substance description:

ingol type
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

diterpen ketons ingol type

Composition #2: Baslas, R. K., Gupta, N. C. Chemical constituents of Euphorbia lactea Ham. herba hungarica, 1984, p. 85–88. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Substance:

Tinyatoxin (RF-00010940-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tinyatoxin

Composition #3: Lynn, K. R., Clevette-Radford, N. A. Lectins from latexes of Euphorbia and Elaeophorbia species. phytochemistry, 1986, p. 1553–1557. .

Language:

English (en)
Substance:

Lectins (RF-00000439-ORG)
Additional substance description:

7 different
Analytical method code:

Chromatographic tests (F015A)
Analytical method - additional description:

gel exclusion chromatography and SDS polyacrylamide disc test electrophoresis
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

lectins

Genotox #1: Upadhyay, Rajiv R., Hecker, Erich. Diterpene esters of the irritant and cocarcinogenic latex of Euphorbia lactea. Phytochemistry (Elsevier), 1975, p. 2514–2516. .

Study category:

Mutagenicity
Type of toxicological test:

subchronic (CHD013TT)
Method type:

in vivo
Tested organism:

House mouse (as animal) (A0CNT)
Route of exposure:

OTHER (OECD0PL)
Exposure duration for in vivo:

24.0
Unit of exposure duration:

Week (G205A)
Number of organisms dosed:

27
Is genotoxic:

No data
Remarks on genotox study:

tumor rate (6/27), death rate 4%, single dose 10 000 ug/app,
Internal remarks:

application of ear of mouse, irritation and tumor shift in 24 weeks, acetone extract of latex
Internal ID:

CAPLUS_1976:135859