EFSA Compendium of Botanicals

Draft - work in progress

Euphorbia heterophylla L.

Family:: Euphorbiaceae
Approval state:: Approved
Number of articles retrieved:: 472
Number of processed references:: 4

Compositions

#1: phorbol #2: saponins #3: Tannins and phlobatannin #4: Alkaloids #5: Cardic Glycoside #6: alkaloids #7: saponins

Endpoint Studies

Genotoxicity

Composition #1: Falodun, A., Agbakwuru, E. P. Phytochemical analysis and laxative activity of the leaf extracts of Euphorbia heterophylla Linn (Euphorbiaceae) . pakistan journal of scientific and industrial research, 2004, vol. 47, no. 5, p. 345–348. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

dichlormethan
Substance:

phorbol (RF-00003989-PAR)
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

phorbol

Composition #2: Falodun, A., Agbakwuru, E. P. Phytochemical analysis and laxative activity of the leaf extracts of Euphorbia heterophylla Linn (Euphorbiaceae) . pakistan journal of scientific and industrial research, 2004, vol. 47, no. 5, p. 345–348. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

dichlormethan
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

saponins

Composition #3: Edeoga, HO., Okwu, DE., Mbaebie, BO. Phytochemical constituents of some Nigerian medicinal plants. AFRICAN JOURNAL OF BIOTECHNOLOGY, 2005, vol. 4, no. 7, p. 685–688. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Drying (dehydration) (A07KG)
Additional extraction description:

water
Substance:

Tannins (RF-00004337-PAR)
Additional substance description:

Tannins and phobotannins
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins and phlobatannin

Composition #4: Edeoga, HO., Okwu, DE., Mbaebie, BO. Phytochemical constituents of some Nigerian medicinal plants. AFRICAN JOURNAL OF BIOTECHNOLOGY, 2005, vol. 4, no. 7, p. 685–688. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method - additional description:

Harborne (1973) method
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids

Composition #5: Edeoga, HO., Okwu, DE., Mbaebie, BO. Phytochemical constituents of some Nigerian medicinal plants. AFRICAN JOURNAL OF BIOTECHNOLOGY, 2005, vol. 4, no. 7, p. 685–688. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

and stems of the plants The plant samples were air-dried and ground
Substance:

cardiac glycosides (RF-00010823-PAR)
Analytical method - additional description:

Keller-Killani test
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Cardic Glycoside

Composition #6: James, Omale., Friday, Emmanuel T. Proximate and nutrient composition of Euphorbia hetrophylla: A medicinal plant from Anyigba, Nigeria . journal of medicinal plants research, 2010, vol. 4, no. 14, p. 1441–1444. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water hot
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

alkaloids

Composition #7: James, Omale., Friday, Emmanuel T. Proximate and nutrient composition of Euphorbia hetrophylla: A medicinal plant from Anyigba, Nigeria . journal of medicinal plants research, 2010, vol. 4, no. 14, p. 1441–1444. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water hot
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

saponins

Endpoint study #1: Adedapo, Adeolu A., Abatan, Matthew O., Olorunsogo, Olufunso O. Toxic effects of some plants in the genus Euphorbia on haematological and biochemical parameters of rats. . veterinarski arhiv, 2004, vol. 74, no. 1, p. 53–62. .

Study relevance:

Human health
Plant part:

Leaves (as part-nature) (A0EKT)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

water
Type of toxicological test:

short-term toxicity (CHD017TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Sprague-Dawley (CHD012ST)
Sex:

Male/Female
Exposure duration:

14.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

5
Control groups used:

yes, concurrent no treatment
Endpoint measured:

Concentration level (CHD013EP)
Concentration unit:

Gram/100 gram (G013A)
Effect concentration:

1
Critical effect:

HEMOPOIETIC (TOX10A)
Target tissue:

Cardiovascular / Haematological (TT001A)
Effect description:

Leucopaenia
Effect or parameter linked to the endpoint:

haematology (CHD023BE)
Internal remarks:

Leucopaenia