EFSA Compendium of Botanicals

Draft - work in progress

Surinam cherry (as plant) // Eugenia uniflora L.

Family:: Myrtaceae
Approval state:: Approved
Number of articles retrieved:: 572
Number of processed references:: 4

Compositions

#1: tannins (stem) #2: saponins (roots) #3: alkaloids #4: saponins #5: anthraquinones #6: cardiac glycosides #7: coumarins #8: quinones #9: oxalates #10: Pyrolizidine alkaloids #11: Ellagitannins #12: Condensed tannins

Endpoint Studies

#1: alfa-glucosidase inhibition

Genotoxicity

Composition #1: Okoh-Esene, Rosemary Uchechukwu., Husseini, Suleiman Jamila., Thomas, Sunday Asuquo. Proximate and phytochemical analysis of leaf, stem and root of Eugenia uniflora (Surinam or Pitanga cherry). journal of natural product and plant resources, 2011, p. 1–4. .

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

tannins (stem)

Composition #2: Okoh-Esene, Rosemary Uchechukwu., Husseini, Suleiman Jamila., Thomas, Sunday Asuquo. Proximate and phytochemical analysis of leaf, stem and root of Eugenia uniflora (Surinam or Pitanga cherry). journal of natural product and plant resources, 2011, p. 1–4. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

saponins (roots)

Composition #3: Daniel, G., Krishnakumari, S. Screening of Eugenia uniflora (L.) leaves in various solvents for qualitative phytochemical constituents. international journal of pharma and bio sciences, 2015, vol. 6, no. 1, p. B1008–B1015. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol, ethanol, petroleum ether, ethyl acetate, acetone, water
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

alkaloids

Composition #4: Daniel, G., Krishnakumari, S. Screening of Eugenia uniflora (L.) leaves in various solvents for qualitative phytochemical constituents. international journal of pharma and bio sciences, 2015, vol. 6, no. 1, p. B1008–B1015. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol, ethanol, ethyl acetate, water
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

saponins

Composition #5: Daniel, G., Krishnakumari, S. Screening of Eugenia uniflora (L.) leaves in various solvents for qualitative phytochemical constituents. international journal of pharma and bio sciences, 2015, vol. 6, no. 1, p. B1008–B1015. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol, ethanol, water
Substance:

anthraquinones (RF-00004343-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

anthraquinones

Composition #6: Daniel, G., Krishnakumari, S. Screening of Eugenia uniflora (L.) leaves in various solvents for qualitative phytochemical constituents. international journal of pharma and bio sciences, 2015, vol. 6, no. 1, p. B1008–B1015. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol, petroleum ether, ethyl acetate, acetone, water
Substance:

cardiac glycosides (RF-00010823-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

cardiac glycosides

Composition #7: Daniel, G., Krishnakumari, S. Screening of Eugenia uniflora (L.) leaves in various solvents for qualitative phytochemical constituents. international journal of pharma and bio sciences, 2015, vol. 6, no. 1, p. B1008–B1015. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol, ethanol, petroleum ether, ethyl acetate, acetone, water
Substance:

coumarins (RF-00004351-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

coumarins

Composition #8: Daniel, G., Krishnakumari, S. Screening of Eugenia uniflora (L.) leaves in various solvents for qualitative phytochemical constituents. international journal of pharma and bio sciences, 2015, vol. 6, no. 1, p. B1008–B1015. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol, ethanol, acetone, water
Substance:

Quinones (RF-00010832-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

quinones

Composition #9: Daniel, G., Krishnakumari, S. Screening of Eugenia uniflora (L.) leaves in various solvents for qualitative phytochemical constituents. international journal of pharma and bio sciences, 2015, vol. 6, no. 1, p. B1008–B1015. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol, ethanol, petroleum ether, ethyl acetate, acetone, water
Substance:

Oxalates (RF-00004308-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

oxalates

Composition #10: Matsumura, T., Kasai, M., Hayashi, T., Arisawa, M., Momose, Y., Arai, I., Amagaya, S., Komatsu, Y. alpha-Glucosidase inhibitors from Paraguayan natural medicine, Nangapiry, the leaves of Eugenia uniflora. PHARMACEUTICAL BIOLOGY, 2000, vol. 38, no. 4, p. 302–307. DOI: 10.1076/1388-0209(200009)3841-AFT302. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hot water
Substance:

Pyrrolizidine alkaloids (RF-00000230-TOX)
Additional substance description:

uniflorine A and B
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Pyrolizidine alkaloids

Composition #11: Lee, MH., Chiou, JF., Yen, KY., Yang, LL. EBV DNA polymerase inhibition of tannins from Eugenia uniflora. CANCER LETTERS, 2000, vol. 154, no. 2, p. 131–136. DOI: 10.1016/S0304-3835(00)00353-0. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acetone (70%)
Substance:

Ellagitannins (hydrolysable tannins) Ellagitannins (hydrolysable tannins) (RF-00004379-PAR)
Additional substance description:

oenothein B, eugeniflorin D1 and eugeniflorin D2
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Ellagitannins

Composition #12: Lee, MH., Chiou, JF., Yen, KY., Yang, LL. EBV DNA polymerase inhibition of tannins from Eugenia uniflora. CANCER LETTERS, 2000, vol. 154, no. 2, p. 131–136. DOI: 10.1016/S0304-3835(00)00353-0. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acetone (70%)
Substance:

Proanthocyanidins (condensed tannins) Proanthocyanidins (condensed tannins) (RF-00004370-PAR)
Additional substance description:

gallocatechin
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Condensed tannins

Endpoint study #1: Matsumura, T., Kasai, M., Hayashi, T., Arisawa, M., Momose, Y., Arai, I., Amagaya, S., Komatsu, Y. alpha-Glucosidase inhibitors from Paraguayan natural medicine, Nangapiry, the leaves of Eugenia uniflora. PHARMACEUTICAL BIOLOGY, 2000, vol. 38, no. 4, p. 302–307. DOI: 10.1076/1388-0209(200009)3841-AFT302. [DOI link]

Study relevance:

Human health
Plant part:

Leaves (as part-nature) (A0EKT)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

water-soluble extract
Type of toxicological test:

in vitro (CHD061TT)
Endpoint measured:

Half maximal inhibitory concentration (CHD021EP)
Concentration unit:

Microgram/millilitre (G052A)
Effect concentration:

120-160
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

alfa-glucosidase inhibition
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

alfa-glucosidase inhibition