EFSA Compendium of Botanicals

Draft - work in progress

Erythroxylum laurifolium Lam.

Family:: Erythroxylaceae
Approval state:: Approved
Number of articles retrieved:: 17
Number of processed references:: 2

Compositions

Endpoint Studies

#1: Alpha-glucosidase inhibition #2: Alpha-amylase inhibition #3: Alpha-glucosidase inhibition

Genotoxicity

Composition #1: Bezanger-Beauquesne, L., Guilbert, N., Deneck, D. Investigation of Erythroxylum laurifolium. Annales Pharmaceutiques Francaises, 1965, p. 377–384. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Drying (dehydration) (A07KG)
Substance:

Tannins (RF-00004337-PAR)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

10.0-15.0
Internal remarks:

Tannins

Composition #2: Bezanger-Beauquesne, L., Guilbert, N., Deneck, D. Investigation of Erythroxylum laurifolium. Annales Pharmaceutiques Francaises, 1965, p. 377–384. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Drying (dehydration) (A07KG)
Substance:

Tannins (RF-00004337-PAR)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

13-13.6
Internal remarks:

Tannins

Endpoint study #1: Picot, Carene M N., Subratty, A Hussein., Mahomoodally, M Fawzi. Inhibitory Potential of Five Traditionally Used Native Antidiabetic Medicinal Plants on alpha -Amylase, alpha -Glucosidase, Glucose Entrapment, and Amylolysis Kinetics In Vitro.. Advances in pharmacological sciences, 2014, vol. 2014, p. 739834–739834. DOI: 10.1155/2014/739834. [DOI link]

Study relevance:

Human health
Plant part:

Unspecified (A07XD)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

aqueous extract
Type of toxicological test:

in vitro (CHD061TT)
Limit test:

Not applicable
Control groups used:

yes
Endpoint measured:

Half maximal inhibitory concentration (CHD021EP)
Concentration unit:

Microgram/millilitre (G052A)
Effect concentration:

12.0
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

alpha-glucosidase inhibition
Effect or parameter linked to the endpoint:

food efficiency (CHD021BE)
Internal remarks:

Alpha-glucosidase inhibition

Endpoint study #2: Picot, Carene M N., Subratty, A Hussein., Mahomoodally, M Fawzi. Inhibitory Potential of Five Traditionally Used Native Antidiabetic Medicinal Plants on alpha -Amylase, alpha -Glucosidase, Glucose Entrapment, and Amylolysis Kinetics In Vitro.. Advances in pharmacological sciences, 2014, vol. 2014, p. 739834–739834. DOI: 10.1155/2014/739834. [DOI link]

Study relevance:

Human health
Plant part:

Unspecified (A07XD)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

methanolic extract
Type of toxicological test:

in vitro (CHD061TT)
Limit test:

Not applicable
Control groups used:

yes
Endpoint measured:

Half maximal inhibitory concentration (CHD021EP)
Concentration unit:

Microgram/millilitre (G052A)
Effect concentration:

7473
Critical effect:

Digestive (TOX18A)
Target tissue:

digestive: Pancreas (TT024A)
Effect description:

alpha-amylase inhibition
Effect or parameter linked to the endpoint:

food efficiency (CHD021BE)
Internal remarks:

Alpha-amylase inhibition

Endpoint study #3: Picot, Carene M N., Subratty, A Hussein., Mahomoodally, M Fawzi. Inhibitory Potential of Five Traditionally Used Native Antidiabetic Medicinal Plants on alpha -Amylase, alpha -Glucosidase, Glucose Entrapment, and Amylolysis Kinetics In Vitro.. Advances in pharmacological sciences, 2014, vol. 2014, p. 739834–739834. DOI: 10.1155/2014/739834. [DOI link]

Study relevance:

Human health
Plant part:

Unspecified (A07XD)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

methanolic extract
Type of toxicological test:

in vitro (CHD061TT)
Limit test:

Not applicable
Control groups used:

yes
Endpoint measured:

Half maximal inhibitory concentration (CHD021EP)
Concentration unit:

Microgram/millilitre (G052A)
Effect concentration:

1.02
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

alpha-glucosidase inhibition
Effect or parameter linked to the endpoint:

food efficiency (CHD021BE)
Internal remarks:

Alpha-glucosidase inhibition