EFSA Compendium of Botanicals

Draft - work in progress

Erythrina verna Vell.

Family:: Fabaceae
Approval state:: Approved
Number of articles retrieved:: 26
Number of processed references:: 3

Compositions

#1: (+)-alpha-hydroxyerysotrine #2: Erythravine #3: isoquinoline alkaloids

Endpoint Studies

Genotoxicity

Composition #1: Flausino, Otavio Aparecido, Jr., Pereira, Ana Maria., Bolzani, Vanderlan da Silva., Nunes-de-Souza, Ricardo Luiz. Effects of erythrinian alkaloids isolated from Erythrina mulungu (Papilionaceae) in mice submitted to animal models of anxiety. Biological Pharmaceutical Bulletin, 2007, p. 375–378. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water-ethanol
Substance:

(+)-alpha-hydroxyerysotrine (RF-00011429-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

(+)-alpha-hydroxyerysotrine

Composition #2: Flausino, Otavio Aparecido, Jr., Pereira, Ana Maria., Bolzani, Vanderlan da Silva., Nunes-de-Souza, Ricardo Luiz. Effects of erythrinian alkaloids isolated from Erythrina mulungu (Papilionaceae) in mice submitted to animal models of anxiety. Biological Pharmaceutical Bulletin, 2007, p. 375–378. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water-ethanol
Substance:

Erythravine (RF-00011144-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Erythravine

Composition #3: Callejon, Daniel R., Riul, Thalita B., Feitosa, Luis G. P., Guaratini, Thais., Silva, Denise B., Adhikari, Achyut., Shrestha, Ram L. (S)., Marques, Lucas M. M., Baruffi, Marcelo D., Lopes, Joao L. C., Lopes, Norberto P. Leishmanicidal Evaluation of Tetrahydroprotoberberine and Spirocyclic Erythrina-Alkaloids. MOLECULES, 2014, vol. 19, no. 5, p. 5692–5703. DOI: 10.3390/molecules19055692. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanolic extract
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

crystamidine, erythraline, erythrinine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

isoquinoline alkaloids

Genotox #1: De Bona, A. P., Batitucci, M. C. P., Andrade, M. A., Riva, J. A. R., Perdigao, T. L. Phytochemical and mutagenic analysis of leaves and inflorescences of Erythrina mulungu (Mart. Ex Benth) through the micronucleus test in rodents. Revista Brasileira de Plantas Medicinais, 2012, p. 344–351. .

Study category:

Genotoxicity
Type of toxicological test:

micronucleus assay (CHD051TT)
Method type:

in vivo
Guideline used:

No guideline followed
Tested organism:

House mouse (as animal) (A0CNT)
Strain of test organism:

Swiss (CHD005ST)
Sex:

Male/Female
Route of exposure:

ORAL: GAVAGE (OECD2231PL)
Exposure duration for in vivo:

200.0
Unit of exposure duration:

Milligram/kilogram (G061A)
Control groups used:

yes
Endpoint measured:

chromosome aberration
Is genotoxic:

Positive
Remarks on genotox study:

The mice were dosed with an hydroalcoholic extract 200 or 400 mg/kg bw,
Internal remarks:

positive micronucleus assay
Internal ID:

CAPLUS_2013:838465