EFSA Compendium of Botanicals

Draft - work in progress

Echinodorus macrophyllus (Kunth) Micheli

Family:: Alismataceae
Approval state:: Approved
Number of articles retrieved:: 62
Number of processed references:: 1

Compositions

Endpoint Studies

Genotoxicity

#1: genotoxicity to E. coli bacterial cells #2: mutagenicity in Salmonella typhimurium (Ames test) #3: mutagenicity in E. coli (reverse mutagenesis to tryptophan prototrophy - WP2 test) #4: mutagenicity in E. coli (lactose mutagenesis assay)

Genotox #1: Vidal, Leonardo S., Alves, Adriana M., Kuster, Ricardo M., Lage, Claudia., Leitao, Alvaro C. Genotoxicity and mutagenicity of Echinodorus macrophyllus (chapeu-de-couro) extracts. GENETICS AND MOLECULAR BIOLOGY, 2010, vol. 33, no. 3, p. 549–557. DOI: 10.1590/S1415-47572010005000060. [DOI link]

Study category:

Genotoxicity
Type of toxicological test:

bacterial gene mutation assay (CHD027TT)
Method type:

in vitro
Tested organism:

Escherichia coli (as organism) (A0CQA)
Strain of test organism:

PQ37 (CHD078ST)
Endpoint measured:

gene mutation
Is genotoxic:

Positive
Remarks on genotox study:

genotoxic to bacterial cells.
Internal remarks:

genotoxicity to E. coli bacterial cells
Internal ID:

WOS:000281913300028

Genotox #2: Vidal, Leonardo S., Alves, Adriana M., Kuster, Ricardo M., Lage, Claudia., Leitao, Alvaro C. Genotoxicity and mutagenicity of Echinodorus macrophyllus (chapeu-de-couro) extracts. GENETICS AND MOLECULAR BIOLOGY, 2010, vol. 33, no. 3, p. 549–557. DOI: 10.1590/S1415-47572010005000060. [DOI link]

Study category:

Mutagenicity
Type of toxicological test:

bacterial reverse mutation assay (CHD028TT)
Method type:

in vitro
Tested organism:

Salmonella typhimurium (as organism) (A0CPZ)
Strain of test organism:

TA 98 (CHD029ST)
Endpoint measured:

gene mutation
Is genotoxic:

Positive
Remarks on genotox study:

A 22-fold increase in the number of spontaneous revertants was observed after treatment of E. coli strain TA98 with lyophilized extract (150 mg/plate)
Internal remarks:

mutagenicity in Salmonella typhimurium (Ames test)
Internal ID:

WOS:000281913300028

Genotox #3: Vidal, Leonardo S., Alves, Adriana M., Kuster, Ricardo M., Lage, Claudia., Leitao, Alvaro C. Genotoxicity and mutagenicity of Echinodorus macrophyllus (chapeu-de-couro) extracts. GENETICS AND MOLECULAR BIOLOGY, 2010, vol. 33, no. 3, p. 549–557. DOI: 10.1590/S1415-47572010005000060. [DOI link]

Study category:

Mutagenicity
Type of toxicological test:

bacterial reverse mutation assay (CHD028TT)
Method type:

in vitro
Tested organism:

Escherichia coli (as organism) (A0CQA)
Endpoint measured:

gene mutation
Is genotoxic:

Positive
Remarks on genotox study:

mutagenicity in E. coli (reverse mutagenesis to tryptophan prototrophy - WP2 test)
Internal remarks:

mutagenicity in E. coli (reverse mutagenesis to tryptophan prototrophy - WP2 test)
Internal ID:

WOS:000281913300028

Genotox #4: Vidal, Leonardo S., Alves, Adriana M., Kuster, Ricardo M., Lage, Claudia., Leitao, Alvaro C. Genotoxicity and mutagenicity of Echinodorus macrophyllus (chapeu-de-couro) extracts. GENETICS AND MOLECULAR BIOLOGY, 2010, vol. 33, no. 3, p. 549–557. DOI: 10.1590/S1415-47572010005000060. [DOI link]

Study category:

Mutagenicity
Type of toxicological test:

bacterial reverse mutation assay (CHD028TT)
Method type:

in vitro
Tested organism:

Escherichia coli (as organism) (A0CQA)
Endpoint measured:

gene mutation
Is genotoxic:

Positive
Remarks on genotox study:

the plant extract specifically reverted strains CC103 (534 revertants) and CC104 (222 revertants) to the Lac+ phenotype.
Internal remarks:

mutagenicity in E. coli (lactose mutagenesis assay)
Internal ID:

WOS:000281913300028