EFSA Compendium of Botanicals

Draft - work in progress

Duranta erecta L.

Family:: Verbenaceae
Approval state:: Approved
Number of articles retrieved:: 65
Number of processed references:: 3

Compositions

#1: pseudo-ginsenoside-RT1 (Saponin) #2: Coumarinolignoids

Endpoint Studies

#1: alimentary tract irritation leading to death (dog) #2: drowsiness, hyperaesthesia and tetanic seizures (cat) #3: alimentary tract irritation leading to death (cat) #4: drowsiness, hyperaesthesia and tetanic seizures (dog)

Genotoxicity

Composition #1: Shahat, A.A., Nazif, N.M., Abousetta, L.M., Ibrahim, N.A., Cos, P., Van Miert, S., Pieters, L., Vlietinck, A.J. Phytochemical investigation and antioxidant activity of Duranta repens. Phytotherapy Research, 2005, vol. 19, no. 12, p. 1071–1073. DOI: 10.1002/ptr.1766. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol extraction
Substance:

Saponins (RF-00004333-PAR)
Additional substance description:

pseudo-ginsenoside-RT1
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

pseudo-ginsenoside-RT1 (Saponin)

Composition #2: Ahmad, N., Zeb, F., Ahmad, I., Wang, F. Repenins A-D, four new antioxidative coumarinolignoids from Duranta repens Linn.. Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, no. 13, p. 3521–3524. DOI: 10.1016/j.bmcl.2009.05.006. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CHCl3
Substance:

Coumarinolignoids (RF-00010800-PAR)
Additional substance description:

Repenins A-D, cleomiscosin A and durantin A
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Coumarinolignoids

Endpoint study #1: Scanlan, S. N. A., Eagles, D. A., Vacher, N. E., Irvine, M. A., Ryan, C. J., Mckenzie, R. A. Duranta erecta poisoning in nine dogs and a cat. AUSTRALIAN VETERINARY JOURNAL, 2006, vol. 84, no. 10, p. 367–370. DOI: 10.1111/j.1751-0813.2006.00039.x. [DOI link]

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Dog (as animal) (A0CNL)
Sex:

Male
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Number of organisms dosed:

9
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

alimentary tract irritation (vomiting, gastric and intestinal haemorrhage, diarrhoea, melaena)
Effect or parameter linked to the endpoint:

mortality (CHD010BE)
Internal remarks:

alimentary tract irritation leading to death (dog)

Endpoint study #2: Scanlan, S. N. A., Eagles, D. A., Vacher, N. E., Irvine, M. A., Ryan, C. J., Mckenzie, R. A. Duranta erecta poisoning in nine dogs and a cat. AUSTRALIAN VETERINARY JOURNAL, 2006, vol. 84, no. 10, p. 367–370. DOI: 10.1111/j.1751-0813.2006.00039.x. [DOI link]

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Cat (as animal) (A0CNM)
Sex:

Male
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Number of organisms dosed:

1
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

NEUROTOXICITY (TOX04A)
Target tissue:

Neurologic (TT004A)
Effect description:

drowsiness, hyperaesthesia and tetanic seizures
Effect or parameter linked to the endpoint:

neurology (CHD027BE)
Internal remarks:

drowsiness, hyperaesthesia and tetanic seizures (cat)

Endpoint study #3: Scanlan, S. N. A., Eagles, D. A., Vacher, N. E., Irvine, M. A., Ryan, C. J., Mckenzie, R. A. Duranta erecta poisoning in nine dogs and a cat. AUSTRALIAN VETERINARY JOURNAL, 2006, vol. 84, no. 10, p. 367–370. DOI: 10.1111/j.1751-0813.2006.00039.x. [DOI link]

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Cat (as animal) (A0CNM)
Sex:

Male
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Number of organisms dosed:

1
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

alimentary tract irritation (vomiting, gastric and intestinal haemorrhage, diarrhoea, melaena)
Effect or parameter linked to the endpoint:

mortality (CHD010BE)
Internal remarks:

alimentary tract irritation leading to death (cat)

Endpoint study #4: Scanlan, S. N. A., Eagles, D. A., Vacher, N. E., Irvine, M. A., Ryan, C. J., Mckenzie, R. A. Duranta erecta poisoning in nine dogs and a cat. AUSTRALIAN VETERINARY JOURNAL, 2006, vol. 84, no. 10, p. 367–370. DOI: 10.1111/j.1751-0813.2006.00039.x. [DOI link]

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Dog (as animal) (A0CNL)
Sex:

Male
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Number of organisms dosed:

9
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

NEUROTOXICITY (TOX04A)
Target tissue:

Neurologic (TT004A)
Effect description:

drowsiness, hyperaesthesia and tetanic seizures
Effect or parameter linked to the endpoint:

neurology (CHD027BE)
Internal remarks:

drowsiness, hyperaesthesia and tetanic seizures (dog)