EFSA Compendium of Botanicals

Draft - work in progress

Drosera peltata Thunb. // Drosera peltata var. lunata (Buch.-Ham. ex DC.) C.B.Clarke // Drosera peltata var. multisepala Y.Z.Ruan

Family:: Droseraceae
Approval state:: Approved
Number of articles retrieved:: 61
Number of processed references:: 7

Compositions

#1: Hydroxydroserone #2: Droserone #3: Plumbagin #4: Naphthoquinones #5: Plumbagin #6: cis-isoshinanolone #7: Droserone #8: Isoshinanolone #9: 3,3´-di-O-methylellagic acid #10: Plumbagin

Endpoint Studies

Genotoxicity

Composition #1: Wang, Qiuan., Shu, Jingyu., Zeng, Longmei. A study on chemical constituents of Drosera peltata Smith var. lunata (Buch.-Ham.) C.B. Clarke collected in Tibet. Zhongguo Zhongyao Zazhi, 1998, vol. 23, no. 11, p. 683–704. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Additional extraction description:

pH gradient extraction, followed by chromatography on silica gel
Substance:

Hydroxydroserone (RF-00011321-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Hydroxydroserone

Composition #2: Asano, Michizo., Hase, Jun-ichi. Hydroxyquinones. X. Pigment of Drosera peltata. Yakugaku Zasshi, 1943, p. 410–411. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol extract
Substance:

droserone (RF-00011302-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Droserone

Composition #3: Asano, Michizo., Hase, Jun-ichi. Hydroxyquinones. X. Pigment of Drosera peltata. Yakugaku Zasshi, 1943, p. 410–411. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol extract
Substance:

plumbagin (RF-00004000-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Plumbagin

Composition #4: Krenn, Liselotte., Laenger, Reinhard., Kopp, Brigitte. Quality control of sundew herb. Part 2. Botanical identification and qualitative and quantitative naphthoquinone determination in commercial samples.. Deutsche Apotheker Zeitung, 1995, p. 41–42. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Substance:

Naphthoquinones (RF-00010839-PAR)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

<=0.06
Internal remarks:

Naphthoquinones

Composition #5: Krenn, Liselotte., Laenger, Reinhard., Kopp, Brigitte. Quality control of sundew herb. Part 2. Botanical identification and qualitative and quantitative naphthoquinone determination in commercial samples.. Deutsche Apotheker Zeitung, 1995, p. 41–42. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Substance:

plumbagin (RF-00004000-PAR)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

<=33.0
Internal remarks:

Plumbagin

Composition #6: Kolodziej, H., Pertz, H.H., Humke, A. Main constituents of a commercial Drosera fluid extract and their antagonist activity at muscarinic M3 receptors in guinea-pig ileum. Pharmazie, 2002, vol. 57, no. 3, p. 201–203. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Additional extraction description:

commercial fluid extract
Substance:

Isoshinanolone (RF-00011310-PAR)
Additional substance description:

cis-isoshinanolone
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

optical rotation, UV, IR, NMR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

cis-isoshinanolone

Composition #7: Kolodziej, H., Pertz, H.H., Humke, A. Main constituents of a commercial Drosera fluid extract and their antagonist activity at muscarinic M3 receptors in guinea-pig ileum. Pharmazie, 2002, vol. 57, no. 3, p. 201–203. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Additional extraction description:

commercial fluid extract
Substance:

droserone (RF-00011302-PAR)
Additional substance description:

droserone
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

optical rotation, UV, IR, NMR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Droserone

Composition #8: Li, Lin., Huang, Jin., Xu, Xianghua., Zhang, Yao., Cheng, Kejun., Yu, Peizhong. [Study on chemical constituents of Drosera peltata var. multisepala].. Chinese materia medica, 2012, vol. 37, no. 2, p. 222–5. .

Language:

English (en)
Additional extraction description:

Chromatographic separation
Substance:

Isoshinanolone (RF-00011310-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isoshinanolone

Composition #9: Braunberger, Christina., Zehl, Martin., Conrad, Juergen., Fischer, Sonja., Adhami, Hamid-Reza., Beifuss, Uwe., Krenn, Liselotte. LC-NMR, NMR, and LC-MS identification and LC-DAD quantification of flavonoids and ellagic acid derivatives in Drosera peltata. AND LIFE SCIENCES, 2013, vol. 932, p. 111–116. DOI: 10.1016/j.jchromb.2013.06.015. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Tannins (RF-00004337-PAR)
Additional substance description:

3,3'-Di-O-methylellagic acid
Analytical method code:

HPLC-DAD (F587A)
Analytical method - additional description:

HPLC-MS, HPLC-NMR
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.031-0.071
Internal remarks:

3,3´-di-O-methylellagic acid

Composition #10: Tian, Jun., Chen, Yuxin., Ma, Bingxin., He, Jingsheng., Tong, Jing., Wang, Youwei. Drosera peltata Smith var. lunata (Buch.-Ham.) C. B. Clarke as a feasible source of plumbagin: phytochemical analysis and antifungal activity assay. WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY, 2014, vol. 30, no. 2, p. 737–745. DOI: 10.1007/s11274-013-1495-x. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol extract, further fractionation by partitioning in other solvents
Substance:

plumbagin (RF-00004000-PAR)
Result unit:

Gram/100 gram (G013A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.074-1.136
Internal remarks:

Plumbagin