EFSA Compendium of Botanicals

Draft - work in progress

Doryphora sassafras Endl.

Family:: Atherospermataceae
Approval state:: Approved
Number of articles retrieved:: 53
Number of processed references:: 5

Compositions

#1: Alkaloids in leaves #2: Alkaloids #3: Methyleugenol #4: Camphor #5: Safrole #6: Isoquinoline alkaloid #7: Isocorydine

Endpoint Studies

Genotoxicity

Composition #1: Gharbo, Samir A., Beal, Jack L., Schlessinger, Richard H., Cava, Michael P., Svoboda, Gordon H. Phytochemical study of Doryphora sassafras. I. Isolation of eight crystalline alkaloids from the leaves. Lloydia, 1965, p. 237–244. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

extraction in dicholoromethane:ethanol
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

liriodenine, choline, doryanine and doryafranine
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids in leaves

Composition #2: Chen, C. Rolland., Beal, Jack L., Doskotch, Raymond W., Mitscher, Lester A., Svoboda, Gordon H. Phytochemical study of Doryphora sassafras. II. Isolation of eleven crystalline alkaloids from the bark. Lloydia, 1974, p. 493–500. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ether-defatted powdered bark was extracted with EtOH
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

doryanine, liriodenine, isocorydine, anonaine, reticuline, corypalline, choline chloride, doryphornine, and doryflavine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids

Composition #3: Brophy, Joseph J., Goldsack, Robert J., House, Alan P.N., Lassak, Erich V. Essential oils of the genus Doryphora. Journal of Essential Oil Research, 1993, vol. 5, no. 6, p. 581–586. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

essential oil from leaves and bark
Substance:

methyleugenol (RF-00003931-PAR)
Analytical method code:

Unspecified (F598A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

27-47
Internal remarks:

Methyleugenol

Composition #4: Brophy, Joseph J., Goldsack, Robert J., House, Alan P.N., Lassak, Erich V. Essential oils of the genus Doryphora. Journal of Essential Oil Research, 1993, vol. 5, no. 6, p. 581–586. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

essential oil from leaves and bark
Substance:

Camphor (RF-00003986-PAR)
Analytical method code:

Unspecified (F598A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

15-19
Internal remarks:

Camphor

Composition #5: Brophy, Joseph J., Goldsack, Robert J., House, Alan P.N., Lassak, Erich V. Essential oils of the genus Doryphora. Journal of Essential Oil Research, 1993, vol. 5, no. 6, p. 581–586. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

essential oil from leaves and bark
Substance:

Safrole (RF-00003651-PAR)
Analytical method code:

Unspecified (F598A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

15-30
Internal remarks:

Safrole

Composition #6: Carroll, AR., Davis, RA., Forster, PI., Guymer, GP., Quinn, RJ. A benzylisoquinoline alkaloid from Doryphora sassafras. JOURNAL OF NATURAL PRODUCTS, 2001, vol. 64, no. 12, p. 1572–1573. DOI: 10.1021/np0101321. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

dichlormethane
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

2-methyl-1-(p-methoxybenzyl)-6,7-methylenedioxyisoquinolinium chloride (a benzylisoquinolinium alkaloid)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

UV, IR, NMR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isoquinoline alkaloid

Composition #7: Buchanan, Malcolm S., Davis, Rohan A., Duffy, Sandra., Avery, Vicky M., Quinn, Ronald J. Antimalarial Benzylisoquinoline Alkaloid from the Rainforest Tree Doryphora sassafras. JOURNAL OF NATURAL PRODUCTS, 2009, vol. 72, no. 8, p. 1541–1543. DOI: 10.1021/np9002564. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

dichlormethane/methanol
Substance:

isocorydine (RF-00003443-PAR)
Additional substance description:

(S)-isocorydine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

UV, IR, NMR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isocorydine