EFSA Compendium of Botanicals

Draft - work in progress

Dodonaea viscosa (L.) Jacq.

Family:: Sapindaceae
Approval state:: Approved
Number of articles retrieved:: 480
Number of processed references:: 9

Compositions

#1: Saponins (leaves) #2: alkaloids (roots) #3: saponins (roots) #4: Tannins (roots) #5: Hautriwaic Acid #6: clerodane diterpenes #7: Oleanolic saponins #8: Tannins #9: Alkaloids (leaves) #10: Coumarin glycosides #11: Cyanogenic glycosides #12: eugenol #13: labdane diterpenes #14: coumaric acid esters #15: labdane diterpenes

Endpoint Studies

Genotoxicity

Composition #1: El-Gengaihi, Souad., Dimetry, Nadia Z., Amer, Sanaa A. A. Phytochemical, acaricidal and biological activity of Dodonaea viscosa L. against the two spotted spider mite Tetranychus urticae Koch. Archives of Phytopathology and Plant Protection, 2011, vol. 44, no. 5, p. 419–425. DOI: 10.1080/03235400903092982. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

butanol water extraction
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saponins (leaves)

Composition #2: Rajamanickam, V., Rajasekaran, A., Anandarajagopal, K., Palanivelu, M., Jesupillai, M., Sivakumar, V. Anti-ulcer activity of various extracts of roots of Dodonaea viscosa. international journal of chemical sciences, 2009, p. 2675–2679. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

alkaloids (roots)

Composition #3: Rajamanickam, V., Rajasekaran, A., Anandarajagopal, K., Palanivelu, M., Jesupillai, M., Sivakumar, V. Anti-ulcer activity of various extracts of roots of Dodonaea viscosa. international journal of chemical sciences, 2009, p. 2675–2679. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

chloroform, ethanol
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

saponins (roots)

Composition #4: Rajamanickam, V., Rajasekaran, A., Anandarajagopal, K., Palanivelu, M., Jesupillai, M., Sivakumar, V. Anti-ulcer activity of various extracts of roots of Dodonaea viscosa. international journal of chemical sciences, 2009, p. 2675–2679. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

chloroform, ethanol, water
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins (roots)

Composition #5: Salinas-Sanchez, David Osvaldo., Zamilpa, Alejandro., Perez, Salud., Herrera-Ruiz, Maribel., Tortoriello, Jaime., Gonzalez-Cortazar, Manases., Jimenez-Ferrer, Enrique. Effect of Hautriwaic Acid Isolated from Dodonaea viscosa in a Model of Kaolin/Carrageenan-Induced Monoarthritis. Planta Medica, 2015, p. 1240–1247. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

dicloromethane
Substance:

Hautriwaic Acid (RF-00010976-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Hautriwaic Acid

Composition #6: Ortega, A., Garcia, PE., Cardenas, J., Mancera, C., Marquina, S., Garduno, MLD., Maldonado, E. Methyl dodonates, a new type of diterpenes with a modified clerodane skeleton from Dodonaea viscosa. TETRAHEDRON, 2001, vol. 57, no. 15, p. 2981–2989. DOI: 10.1016/S0040-4020(01)00161-2. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOAc
Substance:

clerodane-type diterpenes (RF-00004350-PAR)
Additional substance description:

methyl dodonates
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

silica gel column chromatography; IR; EIMS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

clerodane diterpenes

Composition #7: Cao, Shugeng., Brodie, Peggy., Callmander, Martin., Randrianaivo, Richard., Razafitsalama, Jeremi., Rakotobe, Etienne., Rasamison, Vincent E., TenDyke, Karen., Shen, Yongchun., Suh, Edward M., Kingston, David G. I. Antiproliferative Triterpenoid Saponins of Dodonaea viscosa from the Madagascar Dry Forest. JOURNAL OF NATURAL PRODUCTS, 2009, vol. 72, no. 9, p. 1705–1707. DOI: 10.1021/np900293x. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Extraction with EtOH by percolation
Substance:

Oleanolic saponins (RF-00010814-PAR)
Additional substance description:

Dodoneasides A&B
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

HPLC; UV; IR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Oleanolic saponins

Composition #8: Khurram, Muhammad., Hameed, Abdul., Amin, Muhammad Usman., Gul, Ahtasham., Ullah, Naseem., Hassan, Mohammad., Qayum, Abdul., Chishti, Kamran Ahmad., Manzoor, Wajeeha. Phytochemical screening and in vitro evaluation of anticandidal activity of Dodonaea viscosa (L.) Jaeq. (Sapindaceae). AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY, 2011, vol. 5, no. 11, p. 1422–1426. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins

Composition #9: Khurram, Muhammad., Hameed, Abdul., Amin, Muhammad Usman., Gul, Ahtasham., Ullah, Naseem., Hassan, Mohammad., Qayum, Abdul., Chishti, Kamran Ahmad., Manzoor, Wajeeha. Phytochemical screening and in vitro evaluation of anticandidal activity of Dodonaea viscosa (L.) Jaeq. (Sapindaceae). AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY, 2011, vol. 5, no. 11, p. 1422–1426. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Analytical method - additional description:

Mayer’s, Dragendorff’s and Wagner’s reagents
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids (leaves)

Composition #10: Khurram, Muhammad., Hameed, Abdul., Amin, Muhammad Usman., Gul, Ahtasham., Ullah, Naseem., Hassan, Mohammad., Qayum, Abdul., Chishti, Kamran Ahmad., Manzoor, Wajeeha. Phytochemical screening and in vitro evaluation of anticandidal activity of Dodonaea viscosa (L.) Jaeq. (Sapindaceae). AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY, 2011, vol. 5, no. 11, p. 1422–1426. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

Coumarin glycosides
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Coumarin glycosides

Composition #11: Khurram, Muhammad., Hameed, Abdul., Amin, Muhammad Usman., Gul, Ahtasham., Ullah, Naseem., Hassan, Mohammad., Qayum, Abdul., Chishti, Kamran Ahmad., Manzoor, Wajeeha. Phytochemical screening and in vitro evaluation of anticandidal activity of Dodonaea viscosa (L.) Jaeq. (Sapindaceae). AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY, 2011, vol. 5, no. 11, p. 1422–1426. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH
Substance:

Cyanogenic glycosides (RF-00004375-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Cyanogenic glycosides

Composition #12: Shanmugavasan, A., Ramachandran, T. Investigation of the extraction process and phytochemical composition of preparations of Dodonaea viscosa (L.) Jacq.. JOURNAL OF ETHNOPHARMACOLOGY, 2011, vol. 137, no. 3, p. 1172–1176. DOI: 10.1016/j.jep.2011.07.040. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Thermal treatment (heating for preservation) (A07HR)
Substance:

Eugenol (RF-00003807-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.05
Internal remarks:

eugenol

Composition #13: Wabo, Hippolyte Kamdem., Chabert, Philippe., Tane, Pierre., Note, Olivier., Tala, Michel Feussi., Peluso, Jean., Muller, Christian., Kikuchi, Haruhisa., Oshima, Yoshiteru., Lobstein, Annelise. Labdane-type diterpenes and flavones from Dodonaea viscosa. FITOTERAPIA, 2012, vol. 83, no. 5, p. 859–863. DOI: 10.1016/j.fitote.2012.03.014. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

AcOEt
Substance:

labdane diterpenes (RF-00004392-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

NMR ; IR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

labdane diterpenes

Composition #14: MATA, R., CONTRERAS, JL., CRISANTO, D., PEREDMIRANDA, R., CASTANEDA, P., DELRIO, F. CHEMICAL STUDIES ON MEXICAN PLANTS USED IN TRADITIONAL MEDICINE .18. NEW SECONDARY METABOLITES FROM DODONAEA-VISCOSA. JOURNAL OF NATURAL PRODUCTS, 1991, vol. 54, no. 3, p. 913–917. DOI: 10.1021/np50075a033. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CHCL3-MeOH
Substance:

p-coumaric acid (RF-00010717-PAR)
Additional substance description:

coumaric acid esters
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

NMR; UV
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

coumaric acid esters

Composition #15: MATA, R., CONTRERAS, JL., CRISANTO, D., PEREDMIRANDA, R., CASTANEDA, P., DELRIO, F. CHEMICAL STUDIES ON MEXICAN PLANTS USED IN TRADITIONAL MEDICINE .18. NEW SECONDARY METABOLITES FROM DODONAEA-VISCOSA. JOURNAL OF NATURAL PRODUCTS, 1991, vol. 54, no. 3, p. 913–917. DOI: 10.1021/np50075a033. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CHCL3-MeOH
Substance:

labdane diterpenes (RF-00004392-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

NMR; UV
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

labdane diterpenes