EFSA Compendium of Botanicals

Draft - work in progress

Dioscorea japonica Thunb.

Family:: Dioscoreaceae
Approval state:: Approved
Number of articles retrieved:: 329
Number of processed references:: 3

Compositions

#1: Calcium oxalate #2: Diosgenin #3: Progenin III (Prosapogenin A) #4: Furostanol saponins (Coreajaponin A and B)

Endpoint Studies

Genotoxicity

Composition #1: Takami, Wataru. Formation of calcium oxalate crystals in the young leaf of Dioscorea japonica and Zingiber mioga. Botanical Magazine, Tokyo, 1966, p. 350–354. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Substance:

Calcium oxalate (RF-00003960-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Calcium oxalate

Composition #2: Avula, Bharathi., Wang, Yan-Hong., Ali, Zulfiqar., Smillie, Troy J., Khan, Ikhlas A. Chemical fingerprint analysis and quantitative determination of steroidal compounds from Dioscorea villosa, Dioscorea species and dietary supplements using UHPLC-ELSD. Biomedical Chromatography, 2014, p. 281–294. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

Diosgenin (RF-00004094-PAR)
Analytical method - additional description:

UHPLC-ELSD
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.07
Internal remarks:

Diosgenin

Composition #3: Avula, Bharathi., Wang, Yan-Hong., Ali, Zulfiqar., Smillie, Troy J., Khan, Ikhlas A. Chemical fingerprint analysis and quantitative determination of steroidal compounds from Dioscorea villosa, Dioscorea species and dietary supplements using UHPLC-ELSD. Biomedical Chromatography, 2014, p. 281–294. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

prosapogenin A (RF-00004008-PAR)
Additional substance description:

Progenin III
Analytical method - additional description:

UHPLC-ELSD
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.07
Internal remarks:

Progenin III (Prosapogenin A)

Composition #4: Kim, Ki Hyun., Kim, Min Ah., Moon, Eunjung., Kim, Sun Yeou., Choi, Sang Zin., Son, Mi Won., Lee, Kang Ro. Furostanol saponins from the rhizomes of Dioscorea japonica and their effects on NGF induction. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, vol. 21, no. 7, p. 2075–2078. DOI: 10.1016/j.bmcl.2011.02.003. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH (50%)
Substance:

steroidal furostan saponins steroidal furostan saponins (RF-00004397-PAR)
Additional substance description:

Coreajaponin A and B
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Furostanol saponins (Coreajaponin A and B)