EFSA Compendium of Botanicals

Draft - work in progress

Dichroa febrifuga Lour.

Family:: Hydrangeaceae
Approval state:: Approved
Number of articles retrieved:: 229
Number of processed references:: 4

Compositions

#1: Febrifugine (leaves) #2: Alkaloids (root) #3: Alkaloids (leaves) #4: Isofebrifugine (leaves) #5: Lectins #6: Dichroine (α- and β-) #7: 4-quinazolinone #8: Berberine #9: Coumarins

Endpoint Studies

Genotoxicity

Composition #1: Zabolotnaya, E. S., Safronich, L. N. Alkaloids from Dichroa febrifuga introduced into the USSR. trudy vsesoyuznogo nauchno-issledovatel'skogo instituta lekarstvennykh rastenii, 1969, p. 356–361. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Substance:

febrifugine (RF-00010892-PAR)
Additional substance description:

The concentration shown is of total alkaloids in leaves
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.15-0.19
Internal remarks:

Febrifugine (leaves)

Composition #2: Zabolotnaya, E. S., Safronich, L. N. Alkaloids from Dichroa febrifuga introduced into the USSR. trudy vsesoyuznogo nauchno-issledovatel'skogo instituta lekarstvennykh rastenii, 1969, p. 356–361. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Substance:

Alkaloids (RF-00004360-PAR)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.02-0.05
Internal remarks:

Alkaloids (root)

Composition #3: Zabolotnaya, E. S., Safronich, L. N. Alkaloids from Dichroa febrifuga introduced into the USSR. trudy vsesoyuznogo nauchno-issledovatel'skogo instituta lekarstvennykh rastenii, 1969, p. 356–361. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

Total alkaloids of which 0.15-0.19% was febrifugine and 0.1% isofebrifugine
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.5-0.7
Internal remarks:

Alkaloids (leaves)

Composition #4: Zabolotnaya, E. S., Safronich, L. N. Alkaloids from Dichroa febrifuga introduced into the USSR. trudy vsesoyuznogo nauchno-issledovatel'skogo instituta lekarstvennykh rastenii, 1969, p. 356–361. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Substance:

Isofebrifugine (RF-00010891-PAR)
Additional substance description:

Total alkaloids of which 0.15-0.19% was febrifugine and 0.1% isofebrifugine
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.5-0.7
Internal remarks:

Isofebrifugine (leaves)

Composition #5: Zheng, Changwen., Xiao, Xiao., Wang, Yongli. Purification and characterization of the lectin from Dichroa febrifuga Lour (DFL). shengwu huaxue zazhi, 1988, p. 12–20. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

0.9% NaCl/phosphate buffered-saline mixture
Substance:

Lectins (RF-00000439-ORG)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lectins

Composition #6: Zhang, Ya., Li, Chun., Lei, Guo-lian. Study on chemical components of Dichroa febrifuga Lour. zhongguo shiyan fangjixue zazhi, 2010, p. 40–42. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

febrifugine (RF-00010892-PAR)
Additional substance description:

dichroine (α- and β-)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Dichroine (α- and β-)

Composition #7: Zhang, Ya., Li, Chun., Lei, Guo-lian. Study on chemical components of Dichroa febrifuga Lour. zhongguo shiyan fangjixue zazhi, 2010, p. 40–42. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

quinazolin-4-ol (RF-00006271-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

4-quinazolinone

Composition #8: Zhang, Ya., Li, Chun., Lei, Guo-lian. Study on chemical components of Dichroa febrifuga Lour. zhongguo shiyan fangjixue zazhi, 2010, p. 40–42. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

berberine (RF-00003706-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Berberine

Composition #9: Li, Yan., Liu, Ming-chuan., Jin, Lin-hong., Hu, De-yu., Yang, Song. Advances on chemical components and bioactivities of Dichroa febrifuga Lour.. guangzhou huagong, 2011, p. 7–9. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

coumarins (RF-00004351-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Coumarins