EFSA Compendium of Botanicals

Draft - work in progress

Delphinium elatum L.

Family:: Ranunculaceae
Approval state:: Approved
Number of articles retrieved:: 111
Number of processed references:: 7

Compositions

#1: Elatine #2: Nudiculine #3: Alkaloids (total) #4: methyllycaconitine #5: delpheline #6: Nudicauline #7: delectinine #8: Norditerpene alkaloids #9: Eladine #10: Elasine #11: Elanine #12: Pacinine #13: delectinine #14: Ajaconine #15: Lycoctanine #16: Delpheline

Endpoint Studies

Genotoxicity

Composition #1: Dozortseva, P. M. Elatin. Meditsinskaya Promyshlennost SSSR, 1956, p. 31–32. .

Language:

English (en)
Substance:

Elatine (RF-00011105-PAR)
Additional substance description:

No further information available from abstract
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Elatine

Composition #2: Samusenko, L.N., Razakova, D.M., Bessonova, I.A., Gorelova, A.P. Alkaloids of the cultivated species Aconitum chasmanthum and Delphinium elatum. Chemistry of Natural Compounds, 1992, vol. 28, no. 1, p. 125–126. DOI: 10.1007/BF00629818. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

Nudicauline (RF-00011104-PAR)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.27
Internal remarks:

Nudiculine

Composition #3: Samusenko, L.N., Razakova, D.M., Bessonova, I.A., Gorelova, A.P. Alkaloids of the cultivated species Aconitum chasmanthum and Delphinium elatum. Chemistry of Natural Compounds, 1992, vol. 28, no. 1, p. 125–126. DOI: 10.1007/BF00629818. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

Diterpene alkaloids (RF-00004377-PAR)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.24-2.5
Internal remarks:

Alkaloids (total)

Composition #4: Goodson, J.A. The alkaloids of the seeds of delphinium elatum, L.. Journal of the Chemical Society (Resumed), 1943, p. 139–141. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

90% alcohol extract
Substance:

methyllycaconitine (RF-00003494-PAR)
Analytical method code:

Physical tests (F006A)
Analytical method - additional description:

melting point, optical rotation, elemental analysis
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

methyllycaconitine

Composition #5: Goodson, J.A. The alkaloids of the seeds of delphinium elatum, L.. Journal of the Chemical Society (Resumed), 1943, p. 139–141. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

90% alcohol extract
Substance:

Delpheline (RF-00011101-PAR)
Analytical method code:

Physical tests (F006A)
Analytical method - additional description:

melting point, optical rotation, elemental analysis
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.092
Internal remarks:

delpheline

Composition #6: Bessonova, IA., Saidkhodzhaeva, SA. Alkaloids of Delphinium elatum cultivated plants. KHIMIYA PRIRODNYKH SOEDINENII, 1998, no. 2, p. 245–246. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Nudicauline (RF-00011104-PAR)
Additional substance description:

Nudicauline and derivatives
Analytical method code:

Chromatographic tests (F015A)
Analytical method - additional description:

TLC, mass and PMR spectra
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Nudicauline

Composition #7: Bessonova, IA., Saidkhodzhaeva, SA. Alkaloids of Delphinium elatum cultivated plants. KHIMIYA PRIRODNYKH SOEDINENII, 1998, no. 2, p. 245–246. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

delectinine (RF-00011103-PAR)
Analytical method code:

Chromatographic tests (F015A)
Analytical method - additional description:

TLC, mass and PMR spectra
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

delectinine

Composition #8: Wada, Koji., Chiba, Ryota., Kanazawa, Rina., Matsuoka, Kei., Suzuki, Miyako., Ikuta, Midori., Goto, Masuo., Yamashita, Hiroshi., Lee, Kuo-Hsiung. Six new norditerpenoid alkaloids from Delphinium elatum. PHYTOCHEMISTRY LETTERS, 2015, vol. 12, p. 79–83. DOI: 10.1016/j.phytol.2015.02.010. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

Norditerpene alkaloids (RF-00004304-PAR)
Additional substance description:

N-formyl-4,19-secopacinine, iminoisodelpheline, iminodelpheline, iminopaciline, 6-dehydroeladine, elapacidine,pacinine, yunnadelphinine, isodelpheline, and delpheline
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

optical rotation, IR, NMR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Norditerpene alkaloids

Composition #9: PELLETIER, SW., ROSS, SA., KULANTHAIVEL, P. NEW ALKALOIDS FROM DELPHINIUM-ELATUM L. TETRAHEDRON, 1989, vol. 45, no. 7, p. 1887–1892. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH, H2O, hexane
Substance:

Eladine (RF-00011397-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.009
Internal remarks:

Eladine

Composition #10: PELLETIER, SW., ROSS, SA., KULANTHAIVEL, P. NEW ALKALOIDS FROM DELPHINIUM-ELATUM L. TETRAHEDRON, 1989, vol. 45, no. 7, p. 1887–1892. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH, H2O, hexane
Substance:

Elasine (RF-00011400-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.009
Internal remarks:

Elasine

Composition #11: PELLETIER, SW., ROSS, SA., DESAI, HK. A NORDITERPENOID ALKALOID FROM DELPHINIUM-ELATUM. PHYTOCHEMISTRY, 1990, vol. 29, no. 7, p. 2381–2383. DOI: 10.1016/0031-9422(90)83086-G. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH, H2O, hexane
Substance:

Elanine (RF-00011102-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.009
Internal remarks:

Elanine

Composition #12: PELLETIER, SW., ROSS, SA., DESAI, HK. A NORDITERPENOID ALKALOID FROM DELPHINIUM-ELATUM. PHYTOCHEMISTRY, 1990, vol. 29, no. 7, p. 2381–2383. DOI: 10.1016/0031-9422(90)83086-G. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH, H2O, hexane
Substance:

Pacinine (RF-00011396-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.0067
Internal remarks:

Pacinine

Composition #13: PELLETIER, SW., ROSS, SA., DESAI, HK. A NORDITERPENOID ALKALOID FROM DELPHINIUM-ELATUM. PHYTOCHEMISTRY, 1990, vol. 29, no. 7, p. 2381–2383. DOI: 10.1016/0031-9422(90)83086-G. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH, H2O, hexane
Substance:

delectinine (RF-00011103-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.003
Internal remarks:

delectinine

Composition #14: PELLETIER, SW., ROSS, SA., DESAI, HK. A NORDITERPENOID ALKALOID FROM DELPHINIUM-ELATUM. PHYTOCHEMISTRY, 1990, vol. 29, no. 7, p. 2381–2383. DOI: 10.1016/0031-9422(90)83086-G. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH, H2O, hexane
Substance:

ajaconine (RF-00004134-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.0215
Internal remarks:

Ajaconine

Composition #15: PELLETIER, SW., ROSS, SA., DESAI, HK. A NORDITERPENOID ALKALOID FROM DELPHINIUM-ELATUM. PHYTOCHEMISTRY, 1990, vol. 29, no. 7, p. 2381–2383. DOI: 10.1016/0031-9422(90)83086-G. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH, H2O, hexane
Substance:

Lycoctonine (RF-00011106-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.01
Internal remarks:

Lycoctanine

Composition #16: PELLETIER, SW., ROSS, SA., DESAI, HK. A NORDITERPENOID ALKALOID FROM DELPHINIUM-ELATUM. PHYTOCHEMISTRY, 1990, vol. 29, no. 7, p. 2381–2383. DOI: 10.1016/0031-9422(90)83086-G. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH, H2O, hexane
Substance:

Delpheline (RF-00011101-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.016
Internal remarks:

Delpheline