EFSA Compendium of Botanicals

Draft - work in progress

Davilla rugosa Poir.

Family:: Dilleniaceae
Approval state:: Approved
Number of articles retrieved:: 35
Number of processed references:: 4

Compositions

#1: Tannins #2: Saponins #3: saponins #4: coumarins #5: saponins #6: alkaloids #7: lignans #8: tannins

Endpoint Studies

#1: behavioral changes - decrease of total locomotion and increase of immobility time and defecation #2: behavioral changes - increase of total locomotion and decrease the duration of immobility #3: decrease of liver weight #4: bristled fur #5: reduction of the locomotor activity #6: reduction of the extraction of feces and urine

Genotoxicity

Composition #1: Macedo, Jessica Marques., Pellucci Souza, Luciana Godoy., Troncozo Valenzuela, Virgina del Carmem., Oliveira, Alaide Braga., Castilho, Rachel Oliveira., Ribeiro Paiva Jacome, Rose Lisieux. Seasonal variation in the flavonoid and tannin contents and antioxidant activity of Davilla rugosa Poir. Revista de Ciencias Farmaceuticas Basica e Aplicada, 2013, vol. 34, no. 4, p. 585–590. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

10-16.73
Internal remarks:

Tannins

Composition #2: Guaraldo, L., Chagas, DA., Konno, AC., Korn, GP., Pfiffer, T., Nasello, AG. Hydroalcoholic extract and fractions of Davilla rugosa Poiret: effects on spontaneous motor activity and elevated plus-maze behavior. JOURNAL OF ETHNOPHARMACOLOGY, 2000, vol. 72, no. 1-2, p. 61–67. DOI: 10.1016/S0378-8741(00)00198-7. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

The hydroalcoholic (70% ethanl) extract was further fractionated in different solvents.
Substance:

Saponins (RF-00004333-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saponins

Composition #3: Guaraldo, L., Sertie, JAA., Bacchi, EM. Antiulcer action of the hydroalcoholic extract and fractions of Davilla rugosa Poiret in the rat. JOURNAL OF ETHNOPHARMACOLOGY, 2001, vol. 76, no. 2, p. 191–195. DOI: 10.1016/S0378-8741(01)00198-2. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

70% ethanol
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

saponins

Composition #4: Mendes, Fulvio Rieli., Tabach, Ricardo., Carlini, E. A. Evaluation of Baccharis trimera and Davilla rugosa in tests for adaptogen activity. PHYTOTHERAPY RESEARCH, 2007, vol. 21, no. 6, p. 517–522. DOI: 10.1002/ptr.2080. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

50% ethanol
Substance:

coumarins (RF-00004351-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

coumarins

Composition #5: Mendes, Fulvio Rieli., Tabach, Ricardo., Carlini, E. A. Evaluation of Baccharis trimera and Davilla rugosa in tests for adaptogen activity. PHYTOTHERAPY RESEARCH, 2007, vol. 21, no. 6, p. 517–522. DOI: 10.1002/ptr.2080. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

50% ethanol
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

saponins

Composition #6: Mendes, Fulvio Rieli., Tabach, Ricardo., Carlini, E. A. Evaluation of Baccharis trimera and Davilla rugosa in tests for adaptogen activity. PHYTOTHERAPY RESEARCH, 2007, vol. 21, no. 6, p. 517–522. DOI: 10.1002/ptr.2080. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

50% ethanol
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

alkaloids

Composition #7: Mendes, Fulvio Rieli., Tabach, Ricardo., Carlini, E. A. Evaluation of Baccharis trimera and Davilla rugosa in tests for adaptogen activity. PHYTOTHERAPY RESEARCH, 2007, vol. 21, no. 6, p. 517–522. DOI: 10.1002/ptr.2080. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

50% ethanol
Substance:

lignans (RF-00004361-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

lignans

Composition #8: Mendes, Fulvio Rieli., Tabach, Ricardo., Carlini, E. A. Evaluation of Baccharis trimera and Davilla rugosa in tests for adaptogen activity. PHYTOTHERAPY RESEARCH, 2007, vol. 21, no. 6, p. 517–522. DOI: 10.1002/ptr.2080. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

50% ethanol
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

tannins

Endpoint study #1: Guaraldo, L., Chagas, DA., Konno, AC., Korn, GP., Pfiffer, T., Nasello, AG. Hydroalcoholic extract and fractions of Davilla rugosa Poiret: effects on spontaneous motor activity and elevated plus-maze behavior. JOURNAL OF ETHNOPHARMACOLOGY, 2000, vol. 72, no. 1-2, p. 61–67. DOI: 10.1016/S0378-8741(00)00198-7. [DOI link]

Study relevance:

Human health
Plant part:

Stem / stalk (as part-nature) (A067S)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

hyfroalcoholic extract
Type of toxicological test:

acute toxicity (CHD016TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Wistar (CHD013ST)
Sex:

Male
Route of exposure:

ORAL: DRINKING WATER (OECD2229PL)
Exposure duration:

35.0
Unit of exposure duration:

Minute (G074A)
Number of organisms dosed:

273
Control groups used:

yes, plain diet
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligram/kilogram (G061A)
Effect concentration:

>30
Critical effect:

NEUROTOXICITY (TOX04A)
Target tissue:

Neurologic (TT004A)
Effect description:

decrease of total locomotion and increase of immobility time and defecation
Effect or parameter linked to the endpoint:

behaviour (CHD001BE)
Internal remarks:

behavioral changes - decrease of total locomotion and increase of immobility time and defecation

Endpoint study #2: Guaraldo, L., Chagas, DA., Konno, AC., Korn, GP., Pfiffer, T., Nasello, AG. Hydroalcoholic extract and fractions of Davilla rugosa Poiret: effects on spontaneous motor activity and elevated plus-maze behavior. JOURNAL OF ETHNOPHARMACOLOGY, 2000, vol. 72, no. 1-2, p. 61–67. DOI: 10.1016/S0378-8741(00)00198-7. [DOI link]

Study relevance:

Human health
Plant part:

Stem / stalk (as part-nature) (A067S)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

hydroalcoholic extract
Type of toxicological test:

acute toxicity (CHD016TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Wistar (CHD013ST)
Sex:

Male
Route of exposure:

ORAL: DRINKING WATER (OECD2229PL)
Exposure duration:

35.0
Unit of exposure duration:

Minute (G074A)
Number of organisms dosed:

273
Control groups used:

yes, plain diet
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligram/kilogram (G061A)
Effect concentration:

15
Critical effect:

NEUROTOXICITY (TOX04A)
Target tissue:

Neurologic (TT004A)
Effect description:

increase of total locomotion and decrease the duration of immobility
Effect or parameter linked to the endpoint:

behaviour (CHD001BE)
Internal remarks:

behavioral changes - increase of total locomotion and decrease the duration of immobility

Endpoint study #3: Guaraldo, L., Sertie, JAA., Bacchi, EM. Antiulcer action of the hydroalcoholic extract and fractions of Davilla rugosa Poiret in the rat. JOURNAL OF ETHNOPHARMACOLOGY, 2001, vol. 76, no. 2, p. 191–195. DOI: 10.1016/S0378-8741(01)00198-2. [DOI link]

Study relevance:

Human health
Plant part:

Stem / stalk (as part-nature) (A067S)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Type of toxicological test:

short-term toxicity (CHD017TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Wistar (CHD013ST)
Sex:

Male/Female
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Exposure duration:

30.0
Unit of exposure duration:

Day (G134A)
Control groups used:

yes, plain diet
Endpoint measured:

Concentration level (CHD013EP)
Concentration unit:

Milligram/kilogram (G061A)
Effect concentration:

800
Critical effect:

HEPATOTOXICITY (TOX02A)
Target tissue:

digestive: Liver (TT023A)
Effect description:

decrease of liver weight
Effect or parameter linked to the endpoint:

organ weights (CHD012BE)
Internal remarks:

decrease of liver weight

Endpoint study #4: Mendes, Fulvio Rieli., Tabach, Ricardo., Carlini, E. A. Evaluation of Baccharis trimera and Davilla rugosa in tests for adaptogen activity. PHYTOTHERAPY RESEARCH, 2007, vol. 21, no. 6, p. 517–522. DOI: 10.1002/ptr.2080. [DOI link]

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

hydroalcohol extract
Type of toxicological test:

acute toxicity (CHD016TT)
Tested organism:

House mouse (as animal) (A0CNT)
Route of exposure:

ORAL: GAVAGE (OECD2231PL)
Exposure duration:

24.0
Unit of exposure duration:

Hour (G099A)
Number of organisms dosed:

6
Control groups used:

yes, plain diet
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligram/kilogram (G061A)
Effect concentration:

1000
Effect description:

bristled fur
Effect or parameter linked to the endpoint:

no data (CHD002BE)
Internal remarks:

bristled fur

Endpoint study #5: Mendes, Fulvio Rieli., Tabach, Ricardo., Carlini, E. A. Evaluation of Baccharis trimera and Davilla rugosa in tests for adaptogen activity. PHYTOTHERAPY RESEARCH, 2007, vol. 21, no. 6, p. 517–522. DOI: 10.1002/ptr.2080. [DOI link]

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

hydroalcohol extract
Type of toxicological test:

acute toxicity (CHD016TT)
Tested organism:

House mouse (as animal) (A0CNT)
Route of exposure:

ORAL: GAVAGE (OECD2231PL)
Exposure duration:

24.0
Unit of exposure duration:

Hour (G099A)
Number of organisms dosed:

6
Control groups used:

yes, plain diet
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligram/kilogram (G061A)
Effect concentration:

1000
Target tissue:

Neurologic (TT004A)
Effect description:

reduction of the locomotor activity
Effect or parameter linked to the endpoint:

neurology (CHD027BE)
Internal remarks:

reduction of the locomotor activity

Endpoint study #6: Mendes, Fulvio Rieli., Tabach, Ricardo., Carlini, E. A. Evaluation of Baccharis trimera and Davilla rugosa in tests for adaptogen activity. PHYTOTHERAPY RESEARCH, 2007, vol. 21, no. 6, p. 517–522. DOI: 10.1002/ptr.2080. [DOI link]

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

hydroalcohol extract
Type of toxicological test:

acute toxicity (CHD016TT)
Tested organism:

House mouse (as animal) (A0CNT)
Route of exposure:

ORAL: GAVAGE (OECD2231PL)
Exposure duration:

24.0
Unit of exposure duration:

Hour (G099A)
Number of organisms dosed:

6
Control groups used:

yes, plain diet
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligram/kilogram (G061A)
Effect concentration:

1000
Effect description:

reduction of the extraction of feces and urine
Effect or parameter linked to the endpoint:

other (CHD003BE)
Internal remarks:

reduction of the extraction of feces and urine