EFSA Compendium of Botanicals

Draft - work in progress

Dalbergia odorifera T.C.Chen

Family:: Fabaceae
Approval state:: Approved
Number of articles retrieved:: 402
Number of processed references:: 5

Compositions

#1: Formononetin #2: Isoflavones #3: Isoflavones #4: genistein #5: Furan derivatives

Endpoint Studies

#1: alpha-glucosidase inhibition #2: Inhibition of yeast α-glucosidase activity

Genotoxicity

Composition #1: Ha, Hyekyung., Lee, Young-Sun., Lee, Je Hyun., Choi, Hwansoo., Kim, Chungsook. High performance liquid chromatographic analysis of isoflavones in medicinal herbs. Archives of Pharmacal Research, 2005, p. 96–101. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

formononetin (RF-00000291-NTR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Milligram/kilogram (G061A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2152.68-2225.60
Internal remarks:

Formononetin

Composition #2: Choi, Chun Whan., Choi, Yeon Hee., Cha, Mi-Ran., Kim, Young Sup., Yon, Gyu Hwan., Kim, Young-Kyoon., Choi, Sang Un., Kim, Young Ho., Ryu, Shi Yong. Antitumor Components Isolated from the Heartwood Extract of Dalbergia odorifera . journal of the korean society for applied biological chemistry, 2009, vol. 52, no. 4, p. 375–379. DOI: 10.3839/jksabc.2009.067. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

isoflavones (RF-00004359-PAR)
Additional substance description:

medicarpin, formononetin, mucronulatol, 3-calussequinone and (3R)-5'-methoxyvestitol
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isoflavones

Composition #3: Choi, Chun Whan., Choi, Yeon Hee., Cha, Mi-Ran., Yoo, Dae Seok., Kim, Young Sup., Yon, Gyu Hwan., Hong, Kyung Sik., Kim, Young Ho., Ryu, Shi Yong. Yeast alpha-Glucosidase Inhibition by Isoflavones from Plants of Leguminosae as an in Vitro Alternative to Acarbose. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2010, vol. 58, no. 18, p. 9988–9993. DOI: 10.1021/jf101926j. [DOI link]

Language:

English (en)
Plant part:

Wood (as part-nature) (A166P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

isoflavones (RF-00004359-PAR)
Additional substance description:

medicarpin, formononetin, mucronulatol, (3R)-calussequinone, (3R)-5'-methoxyvestitol, tectorigenin, biochanin A, tuberosin, calycosin, daidzein
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

CC, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isoflavones

Composition #4: Choi, Chun Whan., Choi, Yeon Hee., Cha, Mi-Ran., Yoo, Dae Seok., Kim, Young Sup., Yon, Gyu Hwan., Hong, Kyung Sik., Kim, Young Ho., Ryu, Shi Yong. Yeast alpha-Glucosidase Inhibition by Isoflavones from Plants of Leguminosae as an in Vitro Alternative to Acarbose. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2010, vol. 58, no. 18, p. 9988–9993. DOI: 10.1021/jf101926j. [DOI link]

Language:

English (en)
Plant part:

Wood (as part-nature) (A166P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

genistein (RF-00000297-NTR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

CC, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

genistein

Composition #5: Lee, Doug-Sung., Jeong, Gil-Saeng. Arylbenzofuran isolated from Dalbergia odorifera suppresses lipopolysaccharide-induced mouse BV2 microglial cell activation, which protects mouse hippocampal HT22 cells death from neuroinflammation-mediated toxicity. EUROPEAN JOURNAL OF PHARMACOLOGY, 2014, vol. 728, p. 1–8. DOI: 10.1016/j.ejphar.2013.12.041. [DOI link]

Language:

English (en)
Plant part:

Wood (as part-nature) (A166P)
Substance:

furan derivatives (RF-00004396-PAR)
Additional substance description:

Furan derivatives (isoparvifuran and (2R, 3R)-Obtusafuran)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Furan derivatives

Endpoint study #1: Choi, Chun Whan., Choi, Yeon Hee., Cha, Mi-Ran., Yoo, Dae Seok., Kim, Young Sup., Yon, Gyu Hwan., Hong, Kyung Sik., Kim, Young Ho., Ryu, Shi Yong. Yeast alpha-Glucosidase Inhibition by Isoflavones from Plants of Leguminosae as an in Vitro Alternative to Acarbose. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2010, vol. 58, no. 18, p. 9988–9993. DOI: 10.1021/jf101926j. [DOI link]

Study relevance:

Human health
Plant part:

Wood (as part-nature) (A166P)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

methanol
Type of toxicological test:

in vitro (CHD061TT)
Route of exposure:

OTHER (OECD0PL)
Endpoint measured:

Half maximal inhibitory concentration (CHD021EP)
Concentration unit:

Milligram/millilitre (G191A)
Effect concentration:

19.5
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

alpha-glucosidase inhibition
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

alpha-glucosidase inhibition

Endpoint study #2: Zhao, Chunfang., Liu, Yongqiang., Cong, Dengli., Zhang, Hui., Yu, Jiajia., Jiang, Ying., Cui, Xiuyue., Sun, Jiaming. Screening and determination for potential alpha-glucosidase inhibitory constituents from Dalbergia odorifera T. Chen using ultrafiltration-LC/ESI-MSn . biomedical chromatography, 2013, vol. 27, no. 12, p. 1621–1629. DOI: 10.1002/bmc.2970. [DOI link]

Study relevance:

Human health
Substance:

isoflavones (RF-00004359-PAR)
Plant part:

Wood (as part-nature) (A166P)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

Ethanol extract of heartwood
Type of toxicological test:

in vitro (CHD061TT)
Endpoint measured:

Enzyme inhibition (CHD067EP)
Concentration unit:

Milligram/millilitre (G191A)
Effect concentration:

<=8.43
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

Inhibition of yeast α-glucosidase activity
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

Inhibition of yeast α-glucosidase activity