Draft - work in progress
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- Cynanchum viminale (L.) L. // Sarcostemma viminale (L.) R.Br.
Cynanchum viminale (L.) L. // Sarcostemma viminale (L.) R.Br.
- Family:
- Apocynaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 50
- Number of processed references:
- 9
Composition #1: Schaub, F., Kaufmann, H., Stoecklin, W., Reichstein, T. Glycosides and aglycons. CCCVII. Pregnane glycosides of the aerial parts of Sarcostemma viminale. Helvetica Chimica Acta, 1968, p. 738–767. .
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Plant part:
Live plants (as part-nature) (A0BA0)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
hydrolysis (acidic or alcoholic)
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Substance:
cardenolides (RF-00004389-PAR)
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Additional substance description:
metaplexigenin, mono-O-acetyl-mono-O-benzoylsarcostin, 12,20-di-O-benzoylsarcostin
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Value (concentration, content):
traces
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Internal remarks:
cardenolides
Composition #2: Schaub, F., Stoecklin, W., Reichstein, T. Glycosides and aglycons. CCCVIII. Structure of genins G (12-O-benzoyldeacetylmetaplexigenin) and H (di-O-benzoylviminolone) from Sarcostemma viminale stems. Helvetica Chimica Acta, 1968, p. 767–772. .
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Plant part:
Stem / stalk (as part-nature) (A067S)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
hydrolysis
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Substance:
pregnane derivatives (RF-00004313-PAR)
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Pregnane derivatives
Composition #3: Ahmad, Viqar Uddin., Zubair, Muhammad., Abbasi, Muhammad Athar., Kousar, Farzana., Nawaz, Sarfraz A., Choudhary, M. Iqbal., Hussaini, Syed Raziullah. Butyrylcholinesterase inhibitory lignans from Sarcostemma viminale. Proceedings of the Pakistan Academy of Sciences, 2005, p. 167–171. .
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Plant part:
Aerial part of plants (as part-nature) (A166F)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Dried material was extracted with methanol, and the extract further fractionated with n-hexane, chloroform, ethyl acetate and n-butanol and chromatographed using silica gel column. .
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Substance:
Pinoresinol (RF-00011088-PAR)
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Additional substance description:
Pinoresinol and derivatives
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Pinoresinol
Composition #4: Jurgens, Andreas., Dotterl, Stefan., Liede-Schumann, Sigrid., Meve, Ulrich. Chemical diversity of floral volatiles in Asclepiadoideae-Asclepiadeae (Apocynaceae). Biochemical Systematics and Ecology, 2008, p. 842–852. .
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Plant part:
Flower (as part-nature) (A067B)
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Extraction/Preparation method:
Fresh (A166Y)
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Additional extraction description:
Volatiles collected using dynamic-headspace method
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Substance:
Indole (RF-00008427-PAR)
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Additional substance description:
Percent in flower volatiles (not as % in the plant material)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
14.3
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Composition #5: Girme, A.S., Bhalke, R.D., Nirmal, S.A., Chavan, M.J. Chromatographic and chemical analysis of Sarcostemma viminale R. Br.. oriental pharmacy and experimental medicine, 2014, vol. 14, no. 3, p. 279–284. DOI: 10.1007/s13596-014-0157-3.
[
DOI link]
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Plant part:
Live plants (as part-nature) (A0BA0)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
ethyl acetate / methanol
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Substance:
Tannins (RF-00004337-PAR)
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Analytical method code:
Phytochemical screening (F604A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Tannins
Composition #6: Girme, A.S., Bhalke, R.D., Nirmal, S.A., Chavan, M.J. Chromatographic and chemical analysis of Sarcostemma viminale R. Br.. oriental pharmacy and experimental medicine, 2014, vol. 14, no. 3, p. 279–284. DOI: 10.1007/s13596-014-0157-3.
[
DOI link]
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Plant part:
Live plants (as part-nature) (A0BA0)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
petroleum ether / ethyl acetate
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Substance:
Saponins (RF-00004333-PAR)
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Analytical method code:
Phytochemical screening (F604A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Saponins
Composition #7: VLEGGAAR, R., VAN HEERDEN, FR., ANDERSON, LAP., ERASMUS, GL. TOXIC CONSTITUENTS OF THE ASCLEPIADACEAE - STRUCTURE ELUCIDATION OF SARCOVIMISIDE A-C, PREGNANE GLYCOSIDES OF SARCOSTEMMA-VIMINALE. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1993, no. 4, p. 483–487. DOI: 10.1039/p19930000483.
[
DOI link]
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Plant part:
Live plants (as part-nature) (A0BA0)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
methanol
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Substance:
Sarcovimisides (RF-00010822-PAR)
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Additional substance description:
sarcovimisides A, B and C
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Analytical method - additional description:
melting point, NMR, MS
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Sarcovimisides
Composition #8: VLEGGAAR, R., VAN HEERDEN, FR., ANDERSON, LAP., ERASMUS, GL. TOXIC CONSTITUENTS OF THE ASCLEPIADACEAE - STRUCTURE ELUCIDATION OF SARCOVIMISIDE A-C, PREGNANE GLYCOSIDES OF SARCOSTEMMA-VIMINALE. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1993, no. 4, p. 483–487. DOI: 10.1039/p19930000483.
[
DOI link]
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Plant part:
Live plants (as part-nature) (A0BA0)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
methanol
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Substance:
Sarcovimiside B (RF-00011346-PAR)
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Analytical method - additional description:
melting point, NMR, MS
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Result unit:
Milligram/kilogram (G061A)
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Result expression:
Whole weight (B001A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
5.26
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Internal remarks:
Sarcovimiside B
Endpoint study
#1: Steyn, Douw G. Recent investigations into the toxicity of known and unknown poisonous plants in the Union of South Africa. VII. Onderstepoort Journal of Veterinary Research, 1937, p. 111–124. .
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Study relevance:
Animal (target species) health
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Plant part:
Aerial part of plants (as part-nature) (A166F)
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Preparation/Extraction method:
Fresh (A166Y)
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Additional plant/substance description:
Toxic to sheep
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Type of toxicological test:
case report (CHD060TT)
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Tested organism:
Sheep (as animal) (A057G)
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Endpoint measured:
Dose not reported (CHD066EP)
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Effect description:
Mortality
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Effect or parameter linked to the endpoint:
mortality (CHD010BE)
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Internal remarks:
Toxic to sheep
Endpoint study
#2: Cooper, Ross G. Poisoning in ostriches following ingestion of toxic plants - field observations. TROPICAL ANIMAL HEALTH AND PRODUCTION, 2007, vol. 39, no. 6, p. 439–442. DOI: 10.1007/s11250-007-9044-y.
[
DOI link]
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Study relevance:
Animal (target species) health
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Plant part:
Live plants (as part-nature) (A0BA0)
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Preparation/Extraction method:
Drying (dehydration) (A07KG)
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Type of toxicological test:
case report (CHD060TT)
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Tested organism:
Bird (as animal) (A057X)
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Route of exposure:
ORAL: FEED (OECD2230PL)
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Unit of exposure duration:
Hour (G099A)
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Endpoint measured:
Dose not reported (CHD066EP)
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Critical effect:
PULMONARY AND CARDIAC (TOX08A)
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Target tissue:
cardiovascular / haematological: Heart (TT011A)
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Effect description:
heart - atrophy, fluid in the pericardium
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Effect or parameter linked to the endpoint:
organ weights (CHD012BE)
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Internal remarks:
heart - atrophy, fluid in the pericardium
Endpoint study
#3: Cooper, Ross G. Poisoning in ostriches following ingestion of toxic plants - field observations. TROPICAL ANIMAL HEALTH AND PRODUCTION, 2007, vol. 39, no. 6, p. 439–442. DOI: 10.1007/s11250-007-9044-y.
[
DOI link]
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Study relevance:
Animal (target species) health
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Plant part:
Live plants (as part-nature) (A0BA0)
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Preparation/Extraction method:
Drying (dehydration) (A07KG)
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Type of toxicological test:
case report (CHD060TT)
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Tested organism:
Bird (as animal) (A057X)
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Route of exposure:
ORAL: FEED (OECD2230PL)
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Unit of exposure duration:
Hour (G099A)
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Endpoint measured:
Dose not reported (CHD066EP)
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Critical effect:
HEPATOTOXICITY (TOX02A)
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Target tissue:
digestive: Liver (TT023A)
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Effect description:
liver - atrophy
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Effect or parameter linked to the endpoint:
organ weights (CHD012BE)
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Internal remarks:
liver - atrophy
Endpoint study
#4: Cooper, Ross G. Poisoning in ostriches following ingestion of toxic plants - field observations. TROPICAL ANIMAL HEALTH AND PRODUCTION, 2007, vol. 39, no. 6, p. 439–442. DOI: 10.1007/s11250-007-9044-y.
[
DOI link]
-
Study relevance:
Animal (target species) health
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Plant part:
Live plants (as part-nature) (A0BA0)
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Preparation/Extraction method:
Drying (dehydration) (A07KG)
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Type of toxicological test:
case report (CHD060TT)
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Tested organism:
Bird (as animal) (A057X)
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Route of exposure:
ORAL: FEED (OECD2230PL)
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Unit of exposure duration:
Hour (G099A)
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Endpoint measured:
Dose not reported (CHD066EP)
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Critical effect:
NEPHROTOXICITY (TOX03A)
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Target tissue:
urogenital: Kidneys (TT046A)
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Effect description:
kidneys - atrophy
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Effect or parameter linked to the endpoint:
organ weights (CHD012BE)
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Internal remarks:
kidneys - atrophy
Endpoint study
#5: Cooper, Ross G. Poisoning in ostriches following ingestion of toxic plants - field observations. TROPICAL ANIMAL HEALTH AND PRODUCTION, 2007, vol. 39, no. 6, p. 439–442. DOI: 10.1007/s11250-007-9044-y.
[
DOI link]
-
Study relevance:
Animal (target species) health
-
Plant part:
Live plants (as part-nature) (A0BA0)
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Preparation/Extraction method:
Drying (dehydration) (A07KG)
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Type of toxicological test:
case report (CHD060TT)
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Tested organism:
Bird (as animal) (A057X)
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Route of exposure:
ORAL: FEED (OECD2230PL)
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Unit of exposure duration:
Hour (G099A)
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Endpoint measured:
Dose not reported (CHD066EP)
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Critical effect:
PULMONARY AND CARDIAC (TOX08A)
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Target tissue:
respiratory: Lung (TT041A)
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Effect description:
lungs - haemeorrhage, fluid in the pleura
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Effect or parameter linked to the endpoint:
other (CHD003BE)
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Internal remarks:
lungs - haemorrhage, fluid in the pleura
Endpoint study
#6: Cooper, Ross G. Poisoning in ostriches following ingestion of toxic plants - field observations. TROPICAL ANIMAL HEALTH AND PRODUCTION, 2007, vol. 39, no. 6, p. 439–442. DOI: 10.1007/s11250-007-9044-y.
[
DOI link]
-
Study relevance:
Animal (target species) health
-
Plant part:
Live plants (as part-nature) (A0BA0)
-
Preparation/Extraction method:
Drying (dehydration) (A07KG)
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Type of toxicological test:
case report (CHD060TT)
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Tested organism:
Bird (as animal) (A057X)
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Route of exposure:
ORAL: FEED (OECD2230PL)
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Unit of exposure duration:
Hour (G099A)
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Endpoint measured:
Dose not reported (CHD066EP)
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Critical effect:
NEUROTOXICITY (TOX04A)
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Target tissue:
neurologic: Brain (TT034A)
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Effect description:
neurotoxicity, congestion of brain - behavioral changes - beak patting, muscular tremors, head hanging
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Effect or parameter linked to the endpoint:
neurology (CHD027BE)
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Internal remarks:
neurotoxicity, congestion of the brain, behavioral changes - beak patting, muscular tremors, head hanging
Endpoint study
#7: Cooper, Ross G. Poisoning in ostriches following ingestion of toxic plants - field observations. TROPICAL ANIMAL HEALTH AND PRODUCTION, 2007, vol. 39, no. 6, p. 439–442. DOI: 10.1007/s11250-007-9044-y.
[
DOI link]
-
Study relevance:
Animal (target species) health
-
Plant part:
Live plants (as part-nature) (A0BA0)
-
Preparation/Extraction method:
Drying (dehydration) (A07KG)
-
Type of toxicological test:
case report (CHD060TT)
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Tested organism:
Bird (as animal) (A057X)
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Route of exposure:
ORAL: FEED (OECD2230PL)
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Unit of exposure duration:
Hour (G099A)
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Endpoint measured:
Dose not reported (CHD066EP)
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Critical effect:
PULMONARY AND CARDIAC (TOX08A)
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Target tissue:
Respiratory (TT005A)
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Effect description:
emphysema and oedema in the thoraco - abdominal cavity, fluid in periteneum, mortality
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Effect or parameter linked to the endpoint:
mortality (CHD010BE)
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Internal remarks:
emphysema and oedema in the thoraco - abdominal cavity, fluid in the peritoneum, mortality
Endpoint study
#8: Botha, C. J., Penrith, M. -L. Poisonous plants of veterinary and human importance in southern Africa. JOURNAL OF ETHNOPHARMACOLOGY, 2008, vol. 119, no. 3, p. 549–558. DOI: 10.1016/j.jep.2008.07.022.
[
DOI link]
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Study relevance:
Animal (target species) health
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Substance:
pregnane derivatives (RF-00004313-PAR)
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Plant part:
Live plants (as part-nature) (A0BA0)
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Additional plant/substance description:
pregnane glycosides
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Type of toxicological test:
case report (CHD060TT)
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Tested organism:
Ruminants (generic) (as animal) (A169S)
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Route of exposure:
ORAL: FEED (OECD2230PL)
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Control groups used:
no data
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Endpoint measured:
Dose not reported (CHD066EP)
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Critical effect:
NEUROTOXICITY (TOX04A)
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Target tissue:
Neurologic (TT004A)
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Effect description:
Hypersensitivity, incoordination, convulsions, paralysis
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Effect or parameter linked to the endpoint:
neurology (CHD027BE)
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Internal remarks:
neurotoxicity in ruminants
Endpoint study
#9: Botha, C. J., Penrith, M. -L. Poisonous plants of veterinary and human importance in southern Africa. JOURNAL OF ETHNOPHARMACOLOGY, 2008, vol. 119, no. 3, p. 549–558. DOI: 10.1016/j.jep.2008.07.022.
[
DOI link]
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Study relevance:
Animal (target species) health
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Substance:
pregnane derivatives (RF-00004313-PAR)
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Plant part:
Live plants (as part-nature) (A0BA0)
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Additional plant/substance description:
pregnane glycosides
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Type of toxicological test:
case report (CHD060TT)
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Tested organism:
Horse (as animal) (A0B9Z)
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Route of exposure:
ORAL: FEED (OECD2230PL)
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Control groups used:
no data
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Endpoint measured:
Dose not reported (CHD066EP)
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Critical effect:
NEUROTOXICITY (TOX04A)
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Target tissue:
Neurologic (TT004A)
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Effect description:
Hypersensitivity, incoordination, convulsions, paralysis
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Effect or parameter linked to the endpoint:
neurology (CHD027BE)
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Internal remarks:
neurotoxicity in horse