EFSA Compendium of Botanicals

Draft - work in progress

Cynanchum stauntonii (Decne.) Schltr. ex H.Lév.

Family:: Apocynaceae
Approval state:: Approved
Number of articles retrieved:: 57
Number of processed references:: 9

Compositions

#1: steroid glycosides #2: Camphor #3: 2-pentylfuran #4: Neolignans #5: stauntoside C #6: anhydrohirundigenin #7: stauntonine = stauntosaponin #8: 2(3H)-Furanone,dihydro-5-pentyl #9: 5-Pentyl-3H-furan-2-one #10: stauntosaponin A #11: stauntosaponin B #12: hirundoside A #13: glaucogenin C #14: cynatratoside A #15: Furan derivatives #16: Stauntosides (steroidal saponins) #17: Neocynapanogenin 3-O-beta-D-thevetopyranoside = Neocynaversicoside

Endpoint Studies

Genotoxicity

Composition #1: Bai, Hong., Wang, Yuan-shu., Liu, Ai-qin. Advances in the study on the C21 steroid constituents of Cynanchum plants. Tianran Chanwu Yanjiu Yu Kaifa, 2007, p. 897–904. .

Language:

English (en)
Substance:

steroid derivatives steroid derivatives (RF-00004373-PAR)
Additional substance description:

No further information available from abstract
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

steroid glycosides

Composition #2: Tian, Xiao-min., Li, Feng., Huang, Shun-ju., Liu, Jian-hua., Huo, Xin. GC-MS analysis of volatile constituents of Cynanchum stauntonii. Zhongguo Shiyan Fangjixue Zazhi, 2013, p. 111–113. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Steam distillation
Substance:

Camphor (RF-00003986-PAR)
Additional substance description:

The concentration relates to that found in volatile essential oil
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.198
Internal remarks:

Camphor

Composition #3: Tian, Xiao-min., Li, Feng., Huang, Shun-ju., Liu, Jian-hua., Huo, Xin. GC-MS analysis of volatile constituents of Cynanchum stauntonii. Zhongguo Shiyan Fangjixue Zazhi, 2013, p. 111–113. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Steam distillation
Substance:

2-Pentylfuran (RF-00008482-PAR)
Additional substance description:

The concentration relates to that found in volatile essential oil
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

15.509
Internal remarks:

2-pentylfuran

Composition #4: Yu, J.-Q., Zhao, L. Two new glycosides and one new neolignan from the roots of Cynanchum stauntonii. Phytochemistry Letters, 2015, vol. 13, p. 355–359. DOI: 10.1016/j.phytol.2015.07.015. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol extraction with further modifications
Substance:

neolignans (RF-00004386-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Neolignans

Composition #5: Yu, J.-Q., Zhao, L. Two new glycosides and one new neolignan from the roots of Cynanchum stauntonii. Phytochemistry Letters, 2015, vol. 13, p. 355–359. DOI: 10.1016/j.phytol.2015.07.015. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol extraction with further modifications
Substance:

Stauntoside A (RF-00011259-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

stauntoside C

Composition #6: Wang, P., Qin, HL., Zhang, L., Li, ZH., Wang, YH., Zhu, HB. Steroids from the roots of Cynanchum stauntonii. PLANTA MEDICA, 2004, vol. 70, no. 11, p. 1075–1079. DOI: 10.1055/s-2004-832650. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol extraction with further modifications
Substance:

anhydrohirundigenin (RF-00011187-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

anhydrohirundigenin

Composition #7: Wang, P., Qin, HL., Zhang, L., Li, ZH., Wang, YH., Zhu, HB. Steroids from the roots of Cynanchum stauntonii. PLANTA MEDICA, 2004, vol. 70, no. 11, p. 1075–1079. DOI: 10.1055/s-2004-832650. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol extraction with further modifications
Substance:

Stauntoside A (RF-00011259-PAR)
Additional substance description:

stauntonine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

stauntonine = stauntosaponin

Composition #8: Yang, ZC., Wang, BC., Yang, XS., Wang, Q. Chemical composition of the volatile oil from Cynanchum stauntonii and its activities of anti-influenza virus. COLLOIDS AND SURFACES B-BIOINTERFACES, 2005, vol. 43, no. 3-4, p. 198–202. DOI: 10.1016/j.colsurfb.2005.05.003. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Drying (dehydration) (A07KG)
Substance:

Nonano-1,4-lactone (RF-00001780-PAR)
Additional substance description:

2(3H)-Furanone,dihydro-5-pentyl
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

4.176
Internal remarks:

2(3H)-Furanone,dihydro-5-pentyl

Composition #9: Yang, ZC., Wang, BC., Yang, XS., Wang, Q. Chemical composition of the volatile oil from Cynanchum stauntonii and its activities of anti-influenza virus. COLLOIDS AND SURFACES B-BIOINTERFACES, 2005, vol. 43, no. 3-4, p. 198–202. DOI: 10.1016/j.colsurfb.2005.05.003. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Drying (dehydration) (A07KG)
Substance:

5-Pentyl-3H-furan-2-one (RF-00008892-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.847
Internal remarks:

5-Pentyl-3H-furan-2-one

Composition #10: Shibano, Makio., Misaka, Ayaka., Sugiyama, Kayoko., Taniguchi, Masahiko., Baba, Kimiye. Two secopregnane-type steroidal glycosides from Cynanchum stauntonii (Decne.) Schltr.ex Levl.. PHYTOCHEMISTRY LETTERS, 2012, vol. 5, no. 2, p. 304–308. DOI: 10.1016/j.phytol.2012.02.007. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol with further modification
Substance:

Stauntoside A (RF-00011259-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

HR-FAB-MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

stauntosaponin A
completed:

True

Composition #11: Shibano, Makio., Misaka, Ayaka., Sugiyama, Kayoko., Taniguchi, Masahiko., Baba, Kimiye. Two secopregnane-type steroidal glycosides from Cynanchum stauntonii (Decne.) Schltr.ex Levl.. PHYTOCHEMISTRY LETTERS, 2012, vol. 5, no. 2, p. 304–308. DOI: 10.1016/j.phytol.2012.02.007. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol with further modification
Substance:

Stauntoside B (RF-00011455-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

HR-FAB-MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

stauntosaponin B
completed:

True

Composition #12: Shibano, Makio., Misaka, Ayaka., Sugiyama, Kayoko., Taniguchi, Masahiko., Baba, Kimiye. Two secopregnane-type steroidal glycosides from Cynanchum stauntonii (Decne.) Schltr.ex Levl.. PHYTOCHEMISTRY LETTERS, 2012, vol. 5, no. 2, p. 304–308. DOI: 10.1016/j.phytol.2012.02.007. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol with further modification
Substance:

hirundoside A (RF-00011260-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

HR-FAB-MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

hirundoside A
completed:

True

Composition #13: Shibano, Makio., Misaka, Ayaka., Sugiyama, Kayoko., Taniguchi, Masahiko., Baba, Kimiye. Two secopregnane-type steroidal glycosides from Cynanchum stauntonii (Decne.) Schltr.ex Levl.. PHYTOCHEMISTRY LETTERS, 2012, vol. 5, no. 2, p. 304–308. DOI: 10.1016/j.phytol.2012.02.007. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol with further modification
Substance:

Glaucogenin C (RF-00011430-PAR)
Additional substance description:

Glaucogenin C and derivatives
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

HR-FAB-MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

glaucogenin C
completed:

True

Composition #14: Shibano, Makio., Misaka, Ayaka., Sugiyama, Kayoko., Taniguchi, Masahiko., Baba, Kimiye. Two secopregnane-type steroidal glycosides from Cynanchum stauntonii (Decne.) Schltr.ex Levl.. PHYTOCHEMISTRY LETTERS, 2012, vol. 5, no. 2, p. 304–308. DOI: 10.1016/j.phytol.2012.02.007. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol with further modification
Substance:

cynatratoside A (RF-00011312-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

HR-FAB-MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

cynatratoside A
completed:

True

Composition #15: Dong, Wen-Jiang., Ni, Yong-Nian., Kokot, Serge. Quantitative analysis of two adulterants in Cynanchum stauntonii by near-infrared spectroscopy combined with multi-variate calibrations. CHEMICAL PAPERS, 2012, vol. 66, no. 12, p. 1083–1091. DOI: 10.2478/s11696-012-0231-6. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

furan derivatives (RF-00004396-PAR)
Additional substance description:

5-pentyl-(3H)furan- 2-one and dihydro-5- pentyl-2(3H)-furanone
Analytical method code:

IR and Raman Spectroscopy (F010A)
Analytical method - additional description:

near infrared (NIR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Furan derivatives
completed:

True

Composition #16: Yu, Jin-Qian., Deng, An-Jun., Qin, Hai-Lin. Nine new steroidal glycosides from the roots of Cynanchum stauntonii. STEROIDS, 2013, vol. 78, no. 1, p. 79–90. DOI: 10.1016/j.steroids.2012.10.007. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol with further modification
Substance:

Stauntosides (RF-00010837-PAR)
Additional substance description:

stauntosides B, C, D, F, I and J
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Stauntosides (steroidal saponins)

Composition #17: Zhang, Mi., Wang, Jun-Song., Luo, Jun., Wei, Dan-Dan., Kong, Ling-Yi. Glaucogenin E, a new C-21 steroid from Cynanchum stauntonii. NATURAL PRODUCT RESEARCH, 2013, vol. 27, no. 2, p. 176–180. DOI: 10.1080/14786419.2012.665914. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol extraction with further modifications
Substance:

Neocynaversicoside (RF-00011199-PAR)
Additional substance description:

Neocynapanogenin 3-O-beta-D-thevetopyranoside is a sysnonym of Neocynaversicoside
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Neocynapanogenin 3-O-beta-D-thevetopyranoside = Neocynaversicoside