Composition #1: Lorenzo, D., Paz, D., Loayza, I., Vila, R., Canigueral, S., Dellacassa, E. Enantiomeric analysis in the characterization and evaluation of aromatic plants. ingenieria y ciencia quimica, 2002, p. 54–59. .
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Plant part:
Unspecified (A07XD)
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Extraction/Preparation method:
Essential oil (as part-nature) (A166Q)
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Substance:
(+)-pulegone (RF-00003398-PAR)
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Analytical method code:
GC-MS (F046A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Pulegone
Endpoint study
#1: Leite, Barbara L. S., Souza, Thais T., Antoniolli, Angelo R., Guimaraes, Adriana G., Siqueira, Rosana S., Quintans, Jullyana S. S., Bonjardim, Leonardo R., Alves, Pericles B., Blank, Arie F., Botelho, Marco Antonio., Almeida, Jackson R. G. S., Lima, Julianeli T., Araujo, Adriano A. S., Quintans-Junior, Lucindo J. Volatile constituents and behavioral change induced by Cymbopogon winterianus leaf essential oil in rodents . african journal of biotechnology, 2011, vol. 10, no. 42, p. 8312–8319. .
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Study relevance:
Human health
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Plant part:
Leaves (as part-nature) (A0EKT)
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Preparation/Extraction method:
Essential oil (as part-nature) (A166Q)
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Type of toxicological test:
short-term toxicity (CHD017TT)
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Tested organism:
House mouse (as animal) (A0CNT)
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Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
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Unit of exposure duration:
Hour (G099A)
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Endpoint measured:
Concentration level (CHD013EP)
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Concentration unit:
Milligrams per kilogram body weight (G225A)
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Critical effect:
Other toxicities (TOX19A)
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Target tissue:
neurologic: Central Nervous System (TT035A)
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Effect description:
decrease of the spontaneous activity, palpebral ptosis ataxia, analgesia and sedation
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Effect or parameter linked to the endpoint:
behaviour (CHD001BE)
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Internal remarks:
behavioural changes, such as decrease of the spontaneous activity, palpebral ptosis ataxia, analgesia and sedation
Genotox #1: Sinha, Sonali., Jothiramajayam, Manivannan., Ghosh, Manosij., Mukherjee, Anita. Evaluation of toxicity of essential oils palmarosa, citronella, lemongrass and vetiver in human lymphocytes. FOOD AND CHEMICAL TOXICOLOGY, 2014, vol. 68, p. 71–77. DOI: 10.1016/j.fct.2014.02.036.
[
DOI link]
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Study category:
Genotoxicity
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Type of toxicological test:
single cell gel/comet assay in mammalian cells for detection of DNA damage (CHD040TT)
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Guideline used:
According to
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Tested organism:
Human (as organism) (A056J)
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Strain of test organism:
lymphocytes (CHD036ST)
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Exogenous metabolic activation applied:
no data
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Endpoint measured:
DNA damage and/or repair
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Remarks on genotox study:
citronella oil causes significant DNA damage at concentrations of 1000 microgram/ml and above
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Internal remarks:
genotoxicity - DNA damage (in vitro)
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Internal ID:
WOS:000337653000009
