Composition #1: Beelders, Theresa., de Beer, Dalene., Stander, Maria A., Joubert, Elizabeth. Comprehensive Phenolic Profiling of Cyclopia genistoides (L.) Vent. by LC-DAD-MS and -MS/MS Reveals Novel Xanthone and Benzophenone Constituents. MOLECULES, 2014, vol. 19, no. 8, p. 11760–11790. DOI: 10.3390/molecules190811760.
[
DOI link]
-
-
Plant part:
Shoot (as part-nature) (A067T)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Aqueous extract
-
Substance:
Benzophenone derivatives (RF-00010824-PAR)
-
Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Benzophenone derivatives
Endpoint study
#1: Beelders, Theresa., Brand, D. Jacobus., de Beer, Dalene., Malherbe, Christiaan J., Mazibuko, Sithandiwe E., Muller, Christo J. F., Joubert, Elizabeth. Benzophenone C- and O-Glucosides from Cyclopia genistoides (Honeybush) Inhibit Mammalian α-Glucosidase. Journal of Natural Products, 2014, p. 2694–2699. .
-
Study relevance:
Human health
-
Substance:
Benzophenone derivatives (RF-00010824-PAR)
-
Plant part:
Shoot (as part-nature) (A067T)
-
Preparation/Extraction method:
Solvent extraction (A0BZR)
-
Type of toxicological test:
in vitro (CHD061TT)
-
Limit test:
Not applicable
-
-
Route of exposure:
OTHER (OECD0PL)
-
Control groups used:
no data
-
Endpoint measured:
Enzyme inhibition (CHD067EP)
-
Concentration unit:
Millimole (G115A)
-
Effect concentration:
0.2
-
Critical effect:
Digestive (TOX18A)
-
Target tissue:
Digestive (TT002A)
-
Effect description:
alpha-glucosidase inhibition (43-54% at 200 micromoles)
-
Effect or parameter linked to the endpoint:
enzyme inhibition (CHD032BE)
-
Internal remarks:
alpha-glucosidase inhibition
Endpoint study
#2: de Beer, Dalene., Joubert, Elizabeth. Development of HPLC method for Cyclopia subternata phenolic compound analysis and application to other Cyclopia spp. . journal of food composition and analysis, 2010, vol. 23, no. 3, p. 289–297. DOI: 10.1016/j.jfca.2009.10.006.
[
DOI link]
-
Study relevance:
Human health
-
Substance:
luteolin (RF-00000326-NTR)
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Preparation/Extraction method:
Solvent extraction (A0BZR)
-
Additional plant/substance description:
water extract
-
Type of toxicological test:
not reported (CHD015TT)
-
Route of exposure:
OTHER (OECD0PL)
-
Endpoint measured:
Dose not reported (CHD066EP)
-
Critical effect:
ENDOCRINE (TOX12A)
-
Effect description:
phytoestrogenic effect of luteolin present in the aerial parts of the plant
-
Effect or parameter linked to the endpoint:
not reported (CHD030BE)
-
Internal remarks:
luteolin identified as phytoestrogen
