EFSA Compendium of Botanicals

Draft - work in progress

Cyclocarya paliurus (Batalin) Iljinsk.

Family:: Juglandaceae
Approval state:: Approved
Number of articles retrieved:: 384
Number of processed references:: 8

Compositions

#1: Gallic acid #2: Bergenin #3: Triterpene saponins #4: Coumarins #5: Saponins #6: Saponins #7: Sesquiterpene lactones #8: cyclocariosides II and III (triterpene saponins)

Endpoint Studies

#1: Inhibition of alpha-glucosidase - confirmed by in vitro testing

Genotoxicity

Composition #1: Zhang, Juan., Lu, Jin-cai., Xiao, Kai., Lu, Ting., Fan, Jun-wen., Zhang, Li-ming., Zhao, Jie., Yang, Jian-jun. Study on water-soluble constituents in leaves of Cyclocarya paliurus. yaoxue shijian zazhi, 2007, p. 82–84. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

70% ethanol
Substance:

gallic acid (RF-00003821-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

spectral analysis
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Gallic acid

Composition #2: Shu, Rengeng., Shu, Jicheng. Phenols of Cyclocarya paliurus. zhongcaoyao, 2007, p. 507–508. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

Bergenin (RF-00010986-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Bergenin

Composition #3: Xu, Ruiyong., Hong, Yanping., Shangguan, Xinchen., Yin, Zhongping., Jiang, Yan., Chen, Musen. Determination of total triterpene saponins in Cyclocarya paliurus (batal.) I1jinskaja by spectrophotometry. jiangxi nongye daxue xuebao, 2007, p. 449–453. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

Triterpene saponins Triterpene saponins (RF-00004338-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Triterpene saponins

Composition #4: Chen, Jinhua., Huang, Jianan., Liu, Zhonghua. Analysis on chemical constituents in the leaves of Cyclocarya Paliurus. shipin gongye keji, 2009, p. 159–160. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Substance:

coumarins (RF-00004351-PAR)
Analytical method code:

Unspecified (F598A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

4.23-6.63
Internal remarks:

Coumarins

Composition #5: Chen, Jinhua., Huang, Jianan., Liu, Zhonghua. Analysis on chemical constituents in the leaves of Cyclocarya Paliurus. shipin gongye keji, 2009, p. 159–160. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Unspecified (F598A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

9.83-10.99
Internal remarks:

Saponins

Composition #6: Jiang, Xiang-hui., Yuan, Jing., Zhu, Jun-wei., Hu, Xiu-hong., Peng, Yi. Effect of post-harvest processing and extraction methods on total saponin content of Cyclocarya paliurus. beifang yuanyi, 2014, p. 120–123. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water extraction
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Unspecified (F598A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.59-6.52
Internal remarks:

Saponins

Composition #7: Li, Jun., Lu, Yuanyuan., Su, Xiaojian., Li, Fu., She, Zhigang., He, Xingcun., Lin, Yongcheng. A norsesquiterpene lactone and a benzoic acid derivative from the leaves of cyclocarya paliurus and their glucosidase and glycogen phosphorylase inhibiting activites. PLANTA MEDICA, 2008, vol. 74, no. 3, p. 287–289. DOI: 10.1055/s-2008-1034309. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

70% ethanol
Substance:

Sesquiterpene lactones (RF-00004319-PAR)
Additional substance description:

3-Methoxypterolactone and 4-hydroxy-3-methoxybenzoic acid
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Sesquiterpene lactones

Composition #8: Shu, RG., Xu, CR., Li, LN., Yu, ZL. Cyclocariosides II and III: Two secodammarane triterpenoid saponins from Cyclocarya paliurus. PLANTA MEDICA, 1995, vol. 61, no. 6, p. 551–553. DOI: 10.1055/s-2006-959369. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Substance:

Triterpene saponins Triterpene saponins (RF-00004338-PAR)
Additional substance description:

cyclocariosides II and III
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

cyclocariosides II and III (triterpene saponins)

Endpoint study #1: Kurihara, H., Fukami, H., Kusumoto, A., Toyoda, Y., Shibata, H., Matsui, Y., Asami, S., Tanaka, T. Hypoglycemic action of Cyclocarya paliurus (Batal.) Iljinskaja in normal and diabetic mice . bioscience biotechnology and biochemistry, 2003, vol. 67, no. 4, p. 877–880. .

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Additional plant/substance description:

hot water extraction, and freeze drying
Type of toxicological test:

short-term toxicity (CHD017TT)
Tested organism:

House mouse (as animal) (A0CNT)
Sex:

Male
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Exposure duration:

21.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

11
Control groups used:

yes
Endpoint measured:

Enzyme inhibition (CHD067EP)
Concentration unit:

Grams per kilogram body weight per day (G212A)
Effect concentration:

2
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

inhibition of alpha-glucosidase - confirmed by in vitro testing
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

Inhibition of alpha-glucosidase - confirmed by in vitro testing