Draft - work in progress
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- Cyclea peltata (Lam.) Hook.f. & Thomson
Cyclea peltata (Lam.) Hook.f. & Thomson
- Family:
- Menispermaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 50
- Number of processed references:
- 9
Endpoint Studies
#1: depression of motor activity, ptosis, mydriasis, and somnolence, ataxia, absence of grasp and pinnal reflexes, marked hypotonia, gasping, clonic and asphyxia1 convulsions
#2: Diuretic effect
#3: ethanolic of C. peltata reduces blood glucose, serum lipids
#4: decrease in fasting blood glucose, decrease in serum triglycerides
Composition #1: Kupchan, S. Morris., Yokoyama, Naokata., Thyagarajan, B. S. Menispermaceae alkaloids. II. The alkaloids of Cyclea peltata. Journal of Pharmaceutical Sciences, 1961, p. 164–167. .
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-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
petroleum ether, MeOH, chloroform, CHCl3
-
Substance:
tetrandrine (RF-00004075-PAR)
-
Additional substance description:
dl-tetrandrine and d-tetrandrine
-
Analytical method code:
Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
dl- and d-tetrandrine
Composition #2: Kupchan, S. Morris., Yokoyama, Naokata., Thyagarajan, B. S. Menispermaceae alkaloids. II. The alkaloids of Cyclea peltata. Journal of Pharmaceutical Sciences, 1961, p. 164–167. .
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
petroleum ether, MeOH, chloroform, CHCl3
-
Substance:
fangchinoline (RF-00003813-PAR)
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Analytical method code:
Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
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Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
fangchinoline
Composition #3: Kupchan, S. Morris., Yokoyama, Naokata., Thyagarajan, B. S. Menispermaceae alkaloids. II. The alkaloids of Cyclea peltata. Journal of Pharmaceutical Sciences, 1961, p. 164–167. .
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
petroleum ether, MeOH, chloroform, CHCl3
-
Substance:
D-isochondodendrine (RF-00004083-PAR)
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Additional substance description:
isochondrodendrine
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Analytical method code:
Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
isochondrodendrine
Composition #4: An, Yinling., Zhang, Xin., Hu, Wangyun. Chemical constituents from Cyclea peltata. Tianran Chanwu Yanjiu Yu Kaifa, 1999, p. 27–30. .
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Plant part:
Unspecified (A07XD)
-
Substance:
cycleanine (RF-00004243-PAR)
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Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Cycleanine
Composition #5: An, Yinling., Zhang, Xin., Hu, Wangyun. Chemical constituents from Cyclea peltata. Tianran Chanwu Yanjiu Yu Kaifa, 1999, p. 27–30. .
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Plant part:
Unspecified (A07XD)
-
Substance:
tetrandrine (RF-00004075-PAR)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Tetrandrine
Composition #6: An, Yinling., Zhang, Xin., Hu, Wangyun. Chemical constituents from Cyclea peltata. Tianran Chanwu Yanjiu Yu Kaifa, 1999, p. 27–30. .
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Plant part:
Unspecified (A07XD)
-
Substance:
berbamine (RF-00004178-PAR)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Berbamine
Composition #7: An, Yinling., Zhang, Xin., Hu, Wangyun. Chemical constituents from Cyclea peltata. Tianran Chanwu Yanjiu Yu Kaifa, 1999, p. 27–30. .
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-
Plant part:
Unspecified (A07XD)
-
Substance:
magnoflorine (RF-00003919-PAR)
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Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Magnoflorine
Composition #8: An, Yinling., Zhang, Xin., Hu, Wangyun. Chemical constituents from Cyclea peltata. Tianran Chanwu Yanjiu Yu Kaifa, 1999, p. 27–30. .
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Plant part:
Unspecified (A07XD)
-
Substance:
N'-Nor-d-tetrandrine (RF-00011425-PAR)
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Additional substance description:
Syn. N'-Nor-D-tetrandrine (metabolite of tetrandrine, probable misspelling in abstract (cycleanoline - non exixtent))
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Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Cycleanorine
Composition #9: An, Yinling., Zhang, Xin., Hu, Wangyun. Chemical constituents from Cyclea peltata. Tianran Chanwu Yanjiu Yu Kaifa, 1999, p. 27–30. .
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-
Plant part:
Unspecified (A07XD)
-
Additional extraction description:
unspecified
-
Substance:
1-bebeerine (RF-00004118-PAR)
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Additional substance description:
Curine
-
Analytical method code:
Unspecified (F598A)
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Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Curine syn. (-)-Bebeerine
Composition #10: An, Yinling., Zhang, Xin., Hu, Wangyun. Chemical constituents from Cyclea peltata. Tianran Chanwu Yanjiu Yu Kaifa, 1999, p. 27–30. .
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-
Plant part:
Unspecified (A07XD)
-
Additional extraction description:
unspecified
-
Substance:
D-isochondodendrine (RF-00004083-PAR)
-
Analytical method code:
Unspecified (F598A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Isochondrodendrine
Composition #11: Kupchan, S.M., Liepa, A.J., Baxter, R.L., Hintz, H.P.J. New alkaloids and related artifacts from Cyclea peltata. Journal of Organic Chemistry, 1973, vol. 38, no. 10, p. 1846–1852. .
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-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
isopropyl alcohol
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Substance:
fangchinoline (RF-00003813-PAR)
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Additional substance description:
Cycleadrine
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Cycleadrine
Composition #12: Kupchan, S.M., Liepa, A.J., Baxter, R.L., Hintz, H.P.J. New alkaloids and related artifacts from Cyclea peltata. Journal of Organic Chemistry, 1973, vol. 38, no. 10, p. 1846–1852. .
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
isopropyl alcohol
-
Substance:
Alkaloids (RF-00004360-PAR)
-
Additional substance description:
Cycleacurine
-
Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Alkaloid (cycleacurine - not in PubChem, ChemID)
Composition #13: Kupchan, S.M., Liepa, A.J., Baxter, R.L., Hintz, H.P.J. New alkaloids and related artifacts from Cyclea peltata. Journal of Organic Chemistry, 1973, vol. 38, no. 10, p. 1846–1852. .
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
isopropyl alcohol
-
Substance:
N'-Nor-d-tetrandrine (RF-00011425-PAR)
-
Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Cycleanorine
Composition #14: Kupchan, S.M., Liepa, A.J., Baxter, R.L., Hintz, H.P.J. New alkaloids and related artifacts from Cyclea peltata. Journal of Organic Chemistry, 1973, vol. 38, no. 10, p. 1846–1852. .
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
isopropyl alcohol
-
Substance:
Cycleahomine (RF-00011176-PAR)
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Cycleahomine
Composition #15: Kupchan, S.M., Liepa, A.J., Baxter, R.L., Hintz, H.P.J. New alkaloids and related artifacts from Cyclea peltata. Journal of Organic Chemistry, 1973, vol. 38, no. 10, p. 1846–1852. .
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
isopropyl alcohol
-
Substance:
Cycleapeltine (RF-00011222-PAR)
-
Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Cycleapeltine
Composition #16: Pillai, R., Gray, A.I., Uma, V.S. Targeted isolation of alkaloid from Cyclea Peltata and determination of structural formula of Tetrandrine alkaloid based on NMR studies. international journal of phytomedicine, 2010, vol. 2, no. 4, p. 392–401. DOI: 10.5138/ijpm.2010.0975.0185.02055.
[
DOI link]
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
various solvents: Hexane, Chloroform and Methanol
-
Substance:
Cycleapeltine (RF-00011222-PAR)
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Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
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Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Cycleapeltine
Composition #17: Pillai, R., Gray, A.I., Uma, V.S. Targeted isolation of alkaloid from Cyclea Peltata and determination of structural formula of Tetrandrine alkaloid based on NMR studies. international journal of phytomedicine, 2010, vol. 2, no. 4, p. 392–401. DOI: 10.5138/ijpm.2010.0975.0185.02055.
[
DOI link]
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
various solvents: Hexane, Chloroform and Methanol
-
Substance:
Bisbenzylisoquinoline alkaloids (RF-00010792-PAR)
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Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Bisbenzylisoquinoline alkaloids
Composition #18: Pillai, R., Gray, A.I., Uma, V.S. Targeted isolation of alkaloid from Cyclea Peltata and determination of structural formula of Tetrandrine alkaloid based on NMR studies. international journal of phytomedicine, 2010, vol. 2, no. 4, p. 392–401. DOI: 10.5138/ijpm.2010.0975.0185.02055.
[
DOI link]
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
various solvents: Hexane, Chloroform and Methanol
-
Substance:
tetrandrine (RF-00004075-PAR)
-
Analytical method code:
HPLC with standard detection methods (F019A)
-
Analytical method - additional description:
and NMR
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
tetrandrine
Composition #19: Shri Vijaya Kirubha, T., Senthamarai, R., Mariya, P., Mani, P. Pharmacognostical and phytochemical standards of Cyclea peltata. (Lam) Hook.f & Thomson leaves. Journal of Chemical and Pharmaceutical Research, 2012, vol. 4, no. 3, p. 1465–1469. .
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Plant part:
Leaves (as part-nature) (A0EKT)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Ethanol extraction
-
Substance:
Saponins (RF-00004333-PAR)
-
Analytical method code:
Phytochemical screening (F604A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Saponins
Composition #20: Shri Vijaya Kirubha, T., Senthamarai, R., Mariya, P., Mani, P. Pharmacognostical and phytochemical standards of Cyclea peltata. (Lam) Hook.f & Thomson leaves. Journal of Chemical and Pharmaceutical Research, 2012, vol. 4, no. 3, p. 1465–1469. .
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Plant part:
Leaves (as part-nature) (A0EKT)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ethanol and aqueous
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Substance:
Alkaloids (RF-00004360-PAR)
-
Analytical method code:
Phytochemical screening (F604A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Alkaloids
Composition #21: Shri Vijaya Kirubha, T., Senthamarai, R., Mariya, P., Mani, P. Pharmacognostical and phytochemical standards of Cyclea peltata. (Lam) Hook.f & Thomson leaves. Journal of Chemical and Pharmaceutical Research, 2012, vol. 4, no. 3, p. 1465–1469. .
-
-
Plant part:
Leaves (as part-nature) (A0EKT)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ethanol and aqueous
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Substance:
Tannins (RF-00004337-PAR)
-
Analytical method code:
Phytochemical screening (F604A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Tannins
Composition #22: Hullatti, K K., Gopikrishna, U V., Kuppast, I J. Phytochemical investigation and diuretic activity of Cyclea peltata leaf extracts.. Journal of advanced pharmaceutical technology & research, 2011, vol. 2, no. 4, p. 241–4. DOI: 10.4103/2231-4040.90880.
[
DOI link]
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Ethanol extract, petroleum ether extract
-
Substance:
Alkaloids (RF-00004360-PAR)
-
Analytical method code:
Phytochemical screening (F604A)
-
Analytical method - additional description:
TLC
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Alkaloids
Composition #23: Hullatti, K K., Gopikrishna, U V., Kuppast, I J. Phytochemical investigation and diuretic activity of Cyclea peltata leaf extracts.. Journal of advanced pharmaceutical technology & research, 2011, vol. 2, no. 4, p. 241–4. DOI: 10.4103/2231-4040.90880.
[
DOI link]
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Ethanol extraction
-
Substance:
Tannins (RF-00004337-PAR)
-
Analytical method code:
Phytochemical screening (F604A)
-
Analytical method - additional description:
TLC
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Tannins
Composition #24: Hullatti, K K., Gopikrishna, U V., Kuppast, I J. Phytochemical investigation and diuretic activity of Cyclea peltata leaf extracts.. Journal of advanced pharmaceutical technology & research, 2011, vol. 2, no. 4, p. 241–4. DOI: 10.4103/2231-4040.90880.
[
DOI link]
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Ethanol extraction
-
Substance:
Saponins (RF-00004333-PAR)
-
Analytical method code:
Phytochemical screening (F604A)
-
Analytical method - additional description:
TLC
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Saponins
Composition #25: Hullatti, K K., Gopikrishna, U V., Kuppast, I J. Phytochemical investigation and diuretic activity of Cyclea peltata leaf extracts.. Journal of advanced pharmaceutical technology & research, 2011, vol. 2, no. 4, p. 241–4. DOI: 10.4103/2231-4040.90880.
[
DOI link]
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Ethanol extraction
-
Substance:
Diterpenes Diterpenes (RF-00004378-PAR)
-
Analytical method code:
Phytochemical screening (F604A)
-
Analytical method - additional description:
TLC
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Diterpenes
Endpoint study
#1: Kupchan, S. Morris., Yokoyama, Naokata., Thyagarajan, B. S. Menispermaceae alkaloids. II. The alkaloids of Cyclea peltata. Journal of Pharmaceutical Sciences, 1961, p. 164–167. .
-
Study relevance:
Human health
-
Substance:
Alkaloids (RF-00004360-PAR)
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Preparation/Extraction method:
Solvent extraction (A0BZR)
-
Additional plant/substance description:
petroleum ether
-
Type of toxicological test:
not reported (CHD015TT)
-
Tested organism:
House mouse (as animal) (A0CNT)
-
-
Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
-
Control groups used:
no data
-
Endpoint measured:
Dose level (CHD014EP)
-
Concentration unit:
Milligram/kilogram (G061A)
-
Effect concentration:
1000
-
Critical effect:
NEUROTOXICITY (TOX04A)
-
Target tissue:
Muscle, Skeletal (TT055A)
-
Effect description:
depression of motor activity, ptosis, mydriasis, and somnolence, ataxia, absence of grasp and pinnal reflexes, marked hypotonia, gasping, clonic and asphyxia1 convulsions
-
Effect or parameter linked to the endpoint:
neurology (CHD027BE)
-
Internal remarks:
depression of motor activity, ptosis, mydriasis, and somnolence, ataxia, absence of grasp and pinnal reflexes, marked hypotonia, gasping, clonic and asphyxia1 convulsions
Endpoint study
#2: Hullatti, K. K., Sharada, M. S., Kuppasth, I. J. Studies on diuretic activity of three plants from Menispermaceae family. Pharmacia Sinica, 2011, p. 129–134. .
-
Study relevance:
Human health
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Preparation/Extraction method:
Solvent extraction (A0BZR)
-
Additional plant/substance description:
methanol
-
Type of toxicological test:
other (CHD008TT)
-
Tested organism:
Rat (as animal) (A0CNV)
-
Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
-
Number of organisms dosed:
6
-
Endpoint measured:
Dose level (CHD014EP)
-
Concentration unit:
Milligram/kilogram (G061A)
-
Effect concentration:
200
-
Critical effect:
Other toxicities (TOX19A)
-
Target tissue:
urogenital: Urinary Bladder (TT051A)
-
Effect description:
diuretic
-
Effect or parameter linked to the endpoint:
other (CHD003BE)
-
Internal remarks:
Diuretic effect
Endpoint study
#3: Sangeetha, M.S., Priyanga, S., Hemmalakshmi, S., Devaki, K. In vivo antidiabetic potential of Cyclea Peltata in streptozotocin-induced-diabetic rats. Asian Journal of Pharmaceutical and Clinical Research, 2015, vol. 8, no. 1, p. 103–108. .
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Study relevance:
Human health
-
Plant part:
Live plants (as part-nature) (A0BA0)
-
Preparation/Extraction method:
Solvent extraction (A0BZR)
-
Additional plant/substance description:
ethanol
-
Type of toxicological test:
short-term toxicity (CHD017TT)
-
Tested organism:
Rat (as animal) (A0CNV)
-
-
Route of exposure:
ORAL: GAVAGE (OECD2231PL)
-
-
Unit of exposure duration:
Day (G134A)
-
Number of organisms dosed:
5
-
-
Endpoint measured:
Dose level (CHD014EP)
-
Concentration unit:
Milligram/kilogram (G061A)
-
Effect concentration:
400
-
Target tissue:
Digestive (TT002A)
-
Effect description:
ethanolic of C. peltata reduces blood glucose, serum lipids
-
Effect or parameter linked to the endpoint:
other (CHD003BE)
-
Internal remarks:
ethanolic of C. peltata reduces blood glucose, serum lipids
Endpoint study
#4: Kirana, H., Srinivasan, B. P. Effect of Cyclea peltata Lam. roots aqueous extract on glucose levels, lipid profile, insulin, TNF-alpha and skeletal muscle glycogen in type 2 diabetic rats. INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY, 2010, vol. 48, no. 5, p. 499–502. .
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Study relevance:
Human health
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Preparation/Extraction method:
Drying (dehydration) (A07KG)
-
Type of toxicological test:
other (CHD008TT)
-
Tested organism:
Rat (as animal) (A0CNV)
-
-
Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
-
Number of organisms dosed:
6
-
-
Endpoint measured:
Dose level (CHD014EP)
-
Concentration unit:
Milligram/kilogram (G061A)
-
-
Target tissue:
Digestive (TT002A)
-
Effect description:
decrease in fasting blood glucose, decrease in serum triglycerides,
-
Effect or parameter linked to the endpoint:
other (CHD003BE)
-
Internal remarks:
decrease in fasting blood glucose, decrease in serum triglycerides
