EFSA Compendium of Botanicals

Draft - work in progress

Caigua (as plant) // Cyclanthera pedata (L.) Schrad.

Family:: Cucurbitaceae
Approval state:: Approved
Number of articles retrieved:: 62
Number of processed references:: 11

Compositions

#1: Steroid derivative ( Fevicordin B 2-gentiobioside) #2: Cucurbitacin glycoside ((3b,16a,20R)-3,16,20,22,25-Pentahydroxy-5-cucurbiten-11-one 3-[glucosyl-(1->6)-glucoside]) #3: Steroidal glycoside ((3b,6a,12b,17a,20S)-Dammar-24-ene-3,6,12,17,20-pentol 20-[glucosyl-(1->2)-[rhamnosyl-(1->6)]-glucoside] 3-[glucosyl-(1->6)-glucoside] 6-xyloside) #4: Steroidal glycoside (Notoginsenoside K) #5: Terpene glycoside, steroid derivate (Fevicordin B 2-[rhamnosyl-(1->4)-glucosyl-(1->6)-glucoside]) #6: Steroidal glycoside (6,7-Didehydrofevicordin F 3-[glucosyl-(1->6)-glucoside]) #7: Steroidal glycoside (25-Acetyl-6,7-didehydrofevicordin F 3-glucoside) #8: Steroid derivate (25-Acetyl-6,7-didehydrofevicordin F 3-[glucosyl-(1->6)-glucoside]) #9: Cucurbitacins #10: Trypsin inhibitors #11: Cucurbitacin 3 #12: Cucurbitacin 1 #13: Cucurbitacin 2 #14: Cucurbitacin 5 #15: Cucurbitacin 4 #16: Cucurbitacin 6 #17: Cucurbitacins

Endpoint Studies

Genotoxicity

Composition #1: Wishart, DS., Jewison, T., Guo, AC., Wilson, M., Knox, C., Liu, Y., Djoumbou, Y., Mandal, R., Aziat, F., Dong, E., Bouatra, S., Sinelnikov, I., Arndt, D., Xia, J., Liu, P., Yallou, F., Bjorndahl, T., Perez-Pineiro, R., Eisner, R., Allen, F., Neveu, V., Greiner, R., Scalbert, A. Fevicordin B 2-gentiobioside (HMDB35296).. Human Metabolome Database, 2012, vol. 3.0 . .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

cucurbitacins (RF-00004352-PAR)
Additional substance description:

Fevicordin B 2-gentiobioside
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Steroid derivative ( Fevicordin B 2-gentiobioside)

Composition #2: Wishart, DS., Jewison, T., Guo, AC., Wilson, M., Knox, C., Liu, Y., Djoumbou, Y., Mandal, R., Aziat, F., Dong, E., Bouatra, S., Sinelnikov, I., Arndt, D., Xia, J., Liu, P., Yallou, F., Bjorndahl, T., Perez-Pineiro, R., Eisner, R., Allen, F., Neveu, V., Greiner, R., Scalbert, A. (3b,16a,20R)-3,16,20,22,25-Pentahydroxy-5-cucurbiten-11-one 3-[glucosyl-(1->6)-glucoside] (HMDB35345).. Human Metabolome Database, 2012, vol. 3.0 . .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

cucurbitacins (RF-00004352-PAR)
Additional substance description:

(3b,16a,20R)-3,16,20,22,25-Pentahydroxy-5-cucurbiten-11-one 3-[glucosyl-(1->6)-glucoside]
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Cucurbitacin glycoside ((3b,16a,20R)-3,16,20,22,25-Pentahydroxy-5-cucurbiten-11-one 3-[glucosyl-(1->6)-glucoside])

Composition #3: Wishart, DS., Jewison, T., Guo, AC., Wilson, M., Knox, C., Liu, Y., Djoumbou, Y., Mandal, R., Aziat, F., Dong, E., Bouatra, S., Sinelnikov, I., Arndt, D., Xia, J., Liu, P., Yallou, F., Bjorndahl, T., Perez-Pineiro, R., Eisner, R., Allen, F., Neveu, V., Greiner, R., Scalbert, A. (3b,6a,12b,17a,20S)-Dammar-24-ene-3,6,12,17,20-pentol 20-[glucosyl-(1->2)-[rhamnosyl-(1->6)]-glucoside] 3-[glucosyl-(1->6)-glucoside] 6-xyloside (HMDB35350).. Human Metabolome Database, 2012, vol. 3.0 . .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

steroid derivatives steroid derivatives (RF-00004373-PAR)
Additional substance description:

(3b,6a,12b,17a,20S)-Dammar-24-ene-3,6,12,17,20-pentol 20-[glucosyl-(1->2)-[rhamnosyl-(1->6)]-glucoside] 3-[glucosyl-(1->6)-glucoside] 6-xyloside
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Steroidal glycoside ((3b,6a,12b,17a,20S)-Dammar-24-ene-3,6,12,17,20-pentol 20-[glucosyl-(1->2)-[rhamnosyl-(1->6)]-glucoside] 3-[glucosyl-(1->6)-glucoside] 6-xyloside)

Composition #4: Wishart, DS., Jewison, T., Guo, AC., Wilson, M., Knox, C., Liu, Y., Djoumbou, Y., Mandal, R., Aziat, F., Dong, E., Bouatra, S., Sinelnikov, I., Arndt, D., Xia, J., Liu, P., Yallou, F., Bjorndahl, T., Perez-Pineiro, R., Eisner, R., Allen, F., Neveu, V., Greiner, R., Scalbert, A. Notoginsenoside K (HMDB35493).. Human Metabolome Database, 2012, vol. 3.0 . .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

Notoginsenoside K (RF-00010956-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Steroidal glycoside (Notoginsenoside K)

Composition #5: Wishart, DS., Jewison, T., Guo, AC., Wilson, M., Knox, C., Liu, Y., Djoumbou, Y., Mandal, R., Aziat, F., Dong, E., Bouatra, S., Sinelnikov, I., Arndt, D., Xia, J., Liu, P., Yallou, F., Bjorndahl, T., Perez-Pineiro, R., Eisner, R., Allen, F., Neveu, V., Greiner, R., Scalbert, A. Fevicordin B 2-[rhamnosyl-(1->4)-glucosyl-(1->6)-glucoside] (HMDB35498).. Human Metabolome Database, 2012, vol. 3.0 . .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

cucurbitacins (RF-00004352-PAR)
Additional substance description:

Fevicordin B 2-[rhamnosyl-(1->4)-glucosyl-(1->6)-glucoside]
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Terpene glycoside, steroid derivate (Fevicordin B 2-[rhamnosyl-(1->4)-glucosyl-(1->6)-glucoside])

Composition #6: Wishart, DS., Jewison, T., Guo, AC., Wilson, M., Knox, C., Liu, Y., Djoumbou, Y., Mandal, R., Aziat, F., Dong, E., Bouatra, S., Sinelnikov, I., Arndt, D., Xia, J., Liu, P., Yallou, F., Bjorndahl, T., Perez-Pineiro, R., Eisner, R., Allen, F., Neveu, V., Greiner, R., Scalbert, A. 6,7-Didehydrofevicordin F 3-[glucosyl-(1->6)-glucoside] (HMDB36337).. Human Metabolome Database, 2012, vol. 3.0 . .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

steroid derivatives steroid derivatives (RF-00004373-PAR)
Additional substance description:

6,7-Didehydrofevicordin F 3-[glucosyl-(1->6)-glucoside]
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Steroidal glycoside (6,7-Didehydrofevicordin F 3-[glucosyl-(1->6)-glucoside])

Composition #7: Wishart, DS., Jewison, T., Guo, AC., Wilson, M., Knox, C., Liu, Y., Djoumbou, Y., Mandal, R., Aziat, F., Dong, E., Bouatra, S., Sinelnikov, I., Arndt, D., Xia, J., Liu, P., Yallou, F., Bjorndahl, T., Perez-Pineiro, R., Eisner, R., Allen, F., Neveu, V., Greiner, R., Scalbert, A. 25-Acetyl-6,7-didehydrofevicordin F 3-glucoside (HMDB36338).. Human Metabolome Database, 2012, vol. 3.0 . .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

steroid derivatives steroid derivatives (RF-00004373-PAR)
Additional substance description:

25-Acetyl-6,7-didehydrofevicordin F 3-glucoside
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Steroidal glycoside (25-Acetyl-6,7-didehydrofevicordin F 3-glucoside)

Composition #8: Wishart, DS., Jewison, T., Guo, AC., Wilson, M., Knox, C., Liu, Y., Djoumbou, Y., Mandal, R., Aziat, F., Dong, E., Bouatra, S., Sinelnikov, I., Arndt, D., Xia, J., Liu, P., Yallou, F., Bjorndahl, T., Perez-Pineiro, R., Eisner, R., Allen, F., Neveu, V., Greiner, R., Scalbert, A. 25-Acetyl-6,7-didehydrofevicordin F 3-[glucosyl-(1->6)-glucoside] (HMDB36339).. Human Metabolome Database, 2012, vol. 3.0 . .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

steroid derivatives steroid derivatives (RF-00004373-PAR)
Additional substance description:

25-Acetyl-6,7-didehydrofevicordin F 3-[glucosyl-(1->6)-glucoside]
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Steroid derivate (25-Acetyl-6,7-didehydrofevicordin F 3-[glucosyl-(1->6)-glucoside])

Composition #9: De Tommasi, N., De Simone, F., Speranza, G., Pizza, C. Studies on the constituents of Cyclanthera pedata fruits: Isolation and structure elucidation of new triterpenoid saponins. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1999, vol. 47, no. 11, p. 4512–4519. DOI: 10.1021/jf9900128. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Petroleum ether/chloroform/methanol
Substance:

cucurbitacins (RF-00004352-PAR)
Additional substance description:

3beta-(6-O-beta-D-glucopyranosyl- beta-D-glucopyranosyloxy)-16alpha,20,22,25-tetrahydroxycucurbita- 5-en-11-one; 3-beta-(6-O-beta-D-glucopyranosyloxy)- 25-acetoxy-16alpha,20,22-trihydroxycucurbit-5-en-11- one;
Analytical method code:

GC with standard detection methods (F038A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Cucurbitacins

Composition #10: Kowalska, Jolanta., Zablocka, Agnieszka., Wilusz, Tadeusz. Isolation and primary structures of seven serine proteinase inhibitors from Cyclanthera pedata seeds. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2006, vol. 1760, no. 7, p. 1054–1063. DOI: 10.1016/j.bbagen.2006.03.011. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Substance:

Trypsin inhibitors Trypsin inhibitors (RF-00004339-PAR)
Analytical method code:

Gel electrophoresis (F076A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Trypsin inhibitors

Composition #11: DeTommasi, N., DeSimone, F., Speranza, G., Pizza, C. Studies on the constituents of Cyclanthera pedata (Caigua) seeds: Isolation and characterization of six new cucurbitacin glycosides. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1996, vol. 44, no. 8, p. 2020–2025. DOI: 10.1021/jf950532c. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Petrolumether/choroform/methanol
Substance:

cucurbitacins (RF-00004352-PAR)
Additional substance description:

25-acetoxy-2-[(6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]-3,16alpha,20,- 22-tetrahydroxy-29-norcucurbita-1,3,5(10)-trien-11-one
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

and NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Cucurbitacin 3

Composition #12: DeTommasi, N., DeSimone, F., Speranza, G., Pizza, C. Studies on the constituents of Cyclanthera pedata (Caigua) seeds: Isolation and characterization of six new cucurbitacin glycosides. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1996, vol. 44, no. 8, p. 2020–2025. DOI: 10.1021/jf950532c. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Petrolumether/choroform/methanol
Substance:

cucurbitacins (RF-00004352-PAR)
Additional substance description:

25-acetoxy-2-(beta-D-glucopyranosyloxy)- 3,16alpha,20,22-tetrahydroxy-29-norcucurbita-1,3,5(10)-trien-11-one
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

and NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Cucurbitacin 1

Composition #13: DeTommasi, N., DeSimone, F., Speranza, G., Pizza, C. Studies on the constituents of Cyclanthera pedata (Caigua) seeds: Isolation and characterization of six new cucurbitacin glycosides. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1996, vol. 44, no. 8, p. 2020–2025. DOI: 10.1021/jf950532c. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Petrolumether/choroform/methanol
Substance:

cucurbitacins (RF-00004352-PAR)
Additional substance description:

25-acetoxy-2-[(4-O-alpha-L-rhamnopyranosyl- 6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]-3,16alpha,20-trihydroxy-29-norcucurbita-1,3,5- (10) triene-11,22-dione
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

and NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Cucurbitacin 2

Composition #14: DeTommasi, N., DeSimone, F., Speranza, G., Pizza, C. Studies on the constituents of Cyclanthera pedata (Caigua) seeds: Isolation and characterization of six new cucurbitacin glycosides. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1996, vol. 44, no. 8, p. 2020–2025. DOI: 10.1021/jf950532c. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Petrolumether/choroform/methanol
Substance:

cucurbitacins (RF-00004352-PAR)
Additional substance description:

3-beta-(beta-D-glucopyranosyloxy)-25-acetoxy-16alpha,20,22,-trihydroxycucurbit- 5-en-11-one
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

and NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Cucurbitacin 5

Composition #15: DeTommasi, N., DeSimone, F., Speranza, G., Pizza, C. Studies on the constituents of Cyclanthera pedata (Caigua) seeds: Isolation and characterization of six new cucurbitacin glycosides. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1996, vol. 44, no. 8, p. 2020–2025. DOI: 10.1021/jf950532c. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Petrolumether/choroform/methanol
Substance:

cucurbitacins (RF-00004352-PAR)
Additional substance description:

2-[(6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]-3,16alpha,20,22,25-pentahydroxy-29-norcucurbita- 1,3,5(10)-trien-11-one
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

and NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Cucurbitacin 4

Composition #16: DeTommasi, N., DeSimone, F., Speranza, G., Pizza, C. Studies on the constituents of Cyclanthera pedata (Caigua) seeds: Isolation and characterization of six new cucurbitacin glycosides. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1996, vol. 44, no. 8, p. 2020–2025. DOI: 10.1021/jf950532c. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Petrolumether/choroform/methanol
Substance:

cucurbitacins (RF-00004352-PAR)
Additional substance description:

3beta-[(6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]-16alpha,20,22,25-tetrahydroxycucurbit- 5-en-11-one
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

and NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Cucurbitacin 6

Composition #17: DeTommasi, N., DeSimone, F., Speranza, G., Pizza, C. Studies on the constituents of Cyclanthera pedata (Caigua) seeds: Isolation and characterization of six new cucurbitacin glycosides. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1996, vol. 44, no. 8, p. 2020–2025. DOI: 10.1021/jf950532c. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Petroleumether/chloroform/methanol
Substance:

cucurbitacins (RF-00004352-PAR)
Additional substance description:

6 different
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

and NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Cucurbitacins