Draft - work in progress
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- Cycas revoluta Thunb.
Cycas revoluta Thunb.
- Family:
- Cycadaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 468
- Number of processed references:
- 10
Composition #1: Duncan, Mark W., Kopin, Irwin J., Crowley, Jeffrey S., Jones, Sandra M., Markey, Sanford P. Quantification of the putative neurotoxin 2-amino-3-(methylamino)propanoic acid (BMAA) in cycadales: analysis of the seeds of some members of the family Cycadaceae. journal of analytical toxicology, 1989, p. 169–175. .
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Plant part:
Seed (as part-nature) (A066P)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
dichloromethane
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Substance:
Beta-N-Methylamino-L-alanine Beta-N-Methylamino-L-alanine (RF-00010852-PAR)
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Additional substance description:
BMAA quanitified in seed endosperm
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Analytical method code:
GC-MS (F046A)
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Result unit:
Milligram/gram (G060A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
0.32
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Internal remarks:
Beta-N-Methylamino-L-alanine (BMAA)
Composition #2: Nair, Jerald J., van Staden, Johannes. Isolation and quantification of the toxic methylazoxymethanol glycoside macrozamin in selected South African cycad species. South African Journal of Botany, 2012, p. 108–112. .
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Plant part:
Seed (as part-nature) (A066P)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
ethanol 80%
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Substance:
Macrozamin Macrozamin (RF-00010847-PAR)
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Analytical method code:
HPLC with standard detection methods (F019A)
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Result unit:
Percent (G138A)
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Result expression:
Whole weight (B001A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
0.11
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Internal remarks:
Macrozamin (seeds)
Composition #3: Nair, Jerald J., van Staden, Johannes. Isolation and quantification of the toxic methylazoxymethanol glycoside macrozamin in selected South African cycad species. South African Journal of Botany, 2012, p. 108–112. .
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Ethanol 80%
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Substance:
Macrozamin Macrozamin (RF-00010847-PAR)
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Analytical method code:
HPLC with standard detection methods (F019A)
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Result unit:
Percent (G138A)
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Result expression:
Whole weight (B001A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
0.12
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Internal remarks:
Macrozamin (leaves)
Composition #4: Azuma, Hiroshi., Kono, Masumi. Estragole (4-allylanisole) is the primary compound in volatiles emitted from the male and female cones of Cycas revoluta. JOURNAL OF PLANT RESEARCH, 2006, vol. 119, no. 6, p. 671–676. DOI: 10.1007/s10265-006-0019-2.
[
DOI link]
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Plant part:
Cone (as part-nature) (A166G)
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Extraction/Preparation method:
Essential oil (as part-nature) (A166Q)
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Additional extraction description:
volatile
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Substance:
Estragole (RF-00003806-PAR)
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Analytical method code:
GC-MS (F046A)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
67.0-92.7
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Internal remarks:
Estragole (male and female cones)
Composition #5: Azuma, Hiroshi., Kono, Masumi. Estragole (4-allylanisole) is the primary compound in volatiles emitted from the male and female cones of Cycas revoluta. JOURNAL OF PLANT RESEARCH, 2006, vol. 119, no. 6, p. 671–676. DOI: 10.1007/s10265-006-0019-2.
[
DOI link]
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Plant part:
Cone (as part-nature) (A166G)
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Extraction/Preparation method:
Essential oil (as part-nature) (A166Q)
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Additional extraction description:
volatile
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Substance:
methyleugenol (RF-00003931-PAR)
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Analytical method code:
GC-MS (Q) (F344A)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
<=7.0
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Internal remarks:
Methyleugenol ( male and female cones)
Composition #6: Azuma, Hiroshi., Kono, Masumi. Estragole (4-allylanisole) is the primary compound in volatiles emitted from the male and female cones of Cycas revoluta. JOURNAL OF PLANT RESEARCH, 2006, vol. 119, no. 6, p. 671–676. DOI: 10.1007/s10265-006-0019-2.
[
DOI link]
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Plant part:
Cone (as part-nature) (A166G)
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Extraction/Preparation method:
Essential oil (as part-nature) (A166Q)
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Additional extraction description:
volatile
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Substance:
methyl salicylate (RF-00003930-PAR)
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Analytical method code:
GC-MS (F046A)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
1.4-8.1
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Internal remarks:
Methyl salicylate (male and female cones)
Composition #7: Krueger, Thomas., Moench, Bettina., Oppenhaeuser, Steven., Luckas, Bernd. LC-MS/MS determination of the isomeric neurotoxins BMAA (beta-N-methylamino-L-alanine) and DAB (2,4-diaminobutyric acid) in cyanobacteria and seeds of Cycas revoluta and Lathyrus latifolius . toxicon, 2010, vol. 55, no. 2-3, p. 547–557. DOI: 10.1016/j.toxicon.2009.10.009.
[
DOI link]
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Plant part:
Seed (as part-nature) (A066P)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
trichloracetic acid
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Substance:
Beta-N-Methylamino-L-alanine Beta-N-Methylamino-L-alanine (RF-00010852-PAR)
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Additional substance description:
BMAA
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Analytical method code:
LC-MS/MS (F027A)
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Result unit:
Microgram/gram (G049A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
6.96
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Internal remarks:
BMAA (neurotoxin)
Composition #8: Fan, Hua., Qiu, Jiangbing., Fan, Lin., Li, Aifeng. Effects of growth conditions on the production of neurotoxin 2,4-diaminobutyric acid (DAB) in Microcystis aeruginosa and its universal presence in diverse cyanobacteria isolated from freshwater in China . environmental science and pollution research, 2015, vol. 22, no. 8, p. 5943–5951. DOI: 10.1007/s11356-014-3766-y.
[
DOI link]
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
75 % methanol
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Substance:
Beta-N-Methylamino-L-alanine Beta-N-Methylamino-L-alanine (RF-00010852-PAR)
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Additional substance description:
total of free and protein bound form
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Analytical method code:
LC-MS/MS (F027A)
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Result unit:
Microgram/gram (G049A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
0.27
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Internal remarks:
Beta-N-Methylamino-L-alanine (Root)
Composition #9: Fan, Hua., Qiu, Jiangbing., Fan, Lin., Li, Aifeng. Effects of growth conditions on the production of neurotoxin 2,4-diaminobutyric acid (DAB) in Microcystis aeruginosa and its universal presence in diverse cyanobacteria isolated from freshwater in China . environmental science and pollution research, 2015, vol. 22, no. 8, p. 5943–5951. DOI: 10.1007/s11356-014-3766-y.
[
DOI link]
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Plant part:
Stem / stalk (as part-nature) (A067S)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
75 % methanol
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Substance:
Beta-N-Methylamino-L-alanine Beta-N-Methylamino-L-alanine (RF-00010852-PAR)
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Additional substance description:
total of free and protein bound form
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Analytical method code:
LC-MS/MS (F027A)
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Result unit:
Microgram/gram (G049A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
0.262
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Internal remarks:
Beta-N-Methylamino-L-alanine (Stem)
Composition #10: Fan, Hua., Qiu, Jiangbing., Fan, Lin., Li, Aifeng. Effects of growth conditions on the production of neurotoxin 2,4-diaminobutyric acid (DAB) in Microcystis aeruginosa and its universal presence in diverse cyanobacteria isolated from freshwater in China . environmental science and pollution research, 2015, vol. 22, no. 8, p. 5943–5951. DOI: 10.1007/s11356-014-3766-y.
[
DOI link]
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
75 % methanol
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Substance:
Beta-N-Methylamino-L-alanine Beta-N-Methylamino-L-alanine (RF-00010852-PAR)
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Additional substance description:
total of free and protein bound form
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Analytical method code:
LC-MS/MS (F027A)
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Result unit:
Microgram/gram (G049A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
0.168
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Internal remarks:
Beta-N-Methylamino-L-alanine (Leaves)
Composition #11: NISHIDA, K., KOBAYASHI, A., NAGAHAMA, T. STUDIES ON CYCASIN, A NEW TOXIC GLYCOSIDE, OF CYCAS-REVOLUTA THUNB .5. QUANTITATIVE DETERMINATION OF CYCASIN IN CYCAD SEEDS. BULLETIN OF THE AGRICULTURAL CHEMICAL SOCIETY OF JAPAN, 1956, vol. 20, no. 2, p. 74–76. .
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Plant part:
Seed (as part-nature) (A066P)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
MeOH
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Substance:
Cycasin (RF-00011099-PAR)
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Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
0.17-0.28
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Internal remarks:
Cycasin
Endpoint study
#1: Yasuda, Nobuhiro., Shimizu, Tsutomu. Cycad poisoning in cattle in Japan. Studies on spontaneous and experimental cases. Journal of Toxicological Sciences, 1998, vol. 23, no. SUPPL. 2, p. 126–128. .
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Study relevance:
Human health
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Plant part:
Leaves (as part-nature) (A0EKT)
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Preparation/Extraction method:
Fresh (A166Y)
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Type of toxicological test:
short-term toxicity (CHD017TT)
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Tested organism:
Cattle (as animal) (A057E)
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Route of exposure:
ORAL: FEED (OECD2230PL)
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Unit of exposure duration:
Day (G134A)
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Number of organisms dosed:
1
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Endpoint measured:
Dose level (CHD014EP)
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Concentration unit:
Kilogram (G167A)
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Effect concentration:
9.465
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Critical effect:
NEUROTOXICITY (TOX04A)
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Target tissue:
neurologic: Spinal Cord (TT039A)
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Effect description:
dyskinesia, ataxia, vacuolation and fibrillary gliosis in the spinal cord
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Effect or parameter linked to the endpoint:
mobility (CHD011BE)
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Internal remarks:
Neurotoxicity ( Case C )
Endpoint study
#2: Yasuda, Nobuhiro., Shimizu, Tsutomu. Cycad poisoning in cattle in Japan. Studies on spontaneous and experimental cases. Journal of Toxicological Sciences, 1998, vol. 23, no. SUPPL. 2, p. 126–128. .
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Study relevance:
Human health
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Plant part:
Leaves (as part-nature) (A0EKT)
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Preparation/Extraction method:
Fresh (A166Y)
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Type of toxicological test:
short-term toxicity (CHD017TT)
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Tested organism:
Cattle (as animal) (A057E)
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Route of exposure:
ORAL: FEED (OECD2230PL)
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Unit of exposure duration:
Day (G134A)
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Number of organisms dosed:
1
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Endpoint measured:
Dose level (CHD014EP)
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Concentration unit:
Kilogram (G167A)
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Effect concentration:
18.740
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Critical effect:
NEUROTOXICITY (TOX04A)
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Target tissue:
neurologic: Spinal Cord (TT039A)
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Effect description:
dyskinesia, ataxia, vacuolation and spheroids bodies in the spinal cord
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Effect or parameter linked to the endpoint:
mobility (CHD011BE)
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Internal remarks:
Neurotoxicity( Case D )
Endpoint study
#3: Yasuda, Nobuhiro., Shimizu, Tsutomu. Cycad poisoning in cattle in Japan. Studies on spontaneous and experimental cases. Journal of Toxicological Sciences, 1998, vol. 23, no. SUPPL. 2, p. 126–128. .
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Study relevance:
Human health
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Substance:
Cycasin (RF-00011099-PAR)
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Type of toxicological test:
short-term toxicity (CHD017TT)
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Tested organism:
Cattle (as animal) (A057E)
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Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
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Unit of exposure duration:
Day (G134A)
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Number of organisms dosed:
1
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Endpoint measured:
Dose level (CHD014EP)
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Concentration unit:
Milligram/kilogram (G061A)
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Effect concentration:
2.5-5.0
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Critical effect:
NEUROTOXICITY (TOX04A)
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Target tissue:
Neurologic (TT004A)
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Effect description:
depression, anorexia
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Effect or parameter linked to the endpoint:
behaviour (CHD001BE)
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Internal remarks:
Depression, anorexia
Endpoint study
#4: Yasuda, Nobuhiro., Shimizu, Tsutomu. Cycad poisoning in cattle in Japan. Studies on spontaneous and experimental cases. Journal of Toxicological Sciences, 1998, vol. 23, no. SUPPL. 2, p. 126–128. .
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Study relevance:
Human health
-
Substance:
Cycasin (RF-00011099-PAR)
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Type of toxicological test:
short-term toxicity (CHD017TT)
-
Tested organism:
Cattle (as animal) (A057E)
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Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
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Unit of exposure duration:
Day (G134A)
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Number of organisms dosed:
1
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Endpoint measured:
Dose level (CHD014EP)
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Concentration unit:
Milligram/kilogram (G061A)
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Effect concentration:
2.5-5.0
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Critical effect:
HEPATOTOXICITY (TOX02A)
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Target tissue:
digestive: Liver (TT023A)
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Effect description:
symptoms of liver necrosis
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Effect or parameter linked to the endpoint:
mortality (CHD010BE)
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Internal remarks:
hepatotoxicity leading to mortality
Endpoint study
#5: Caloni, F., Cortinovis, C., Rivolta, M., Alonge, S., Davanzo, F. Plant poisoning in domestic animals: epidemiological data from an Italian survey (2000-2011). VETERINARY RECORD, 2013, vol. 172, no. 22, p. 580–+. DOI: 10.1136/vr.101225.
[
DOI link]
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Study relevance:
Human health
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Substance:
Cycasin (RF-00011099-PAR)
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Type of toxicological test:
case report (CHD060TT)
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Tested organism:
Dog (as animal) (A0CNL)
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Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
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Number of organisms dosed:
7
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Endpoint measured:
Dose not reported (CHD066EP)
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Critical effect:
NEUROTOXICITY (TOX04A)
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Target tissue:
cardiovascular / haematological: Heart (TT011A)
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Effect description:
Vomiting, tachycardia, tremors, seizures
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Effect or parameter linked to the endpoint:
neurology (CHD027BE)
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Internal remarks:
neurotoxicity
Endpoint study
#6: Cortinovis, Cristina., Caloni, Francesca. Epidemiology of intoxication of domestic animals by plants in Europe. veterinary journal, 2013, vol. 197, no. 2, p. 163–168. DOI: 10.1016/j.tvjl.2013.03.007.
[
DOI link]
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Study relevance:
Human health
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Substance:
Cycasin (RF-00011099-PAR)
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Type of toxicological test:
case report (CHD060TT)
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Tested organism:
Dog (as animal) (A0CNL)
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Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
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Control groups used:
no data
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Endpoint measured:
Dose not reported (CHD066EP)
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Critical effect:
Digestive (TOX18A)
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Target tissue:
Digestive (TT002A)
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Effect description:
gastrointestinal toxicity
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Effect or parameter linked to the endpoint:
no data (CHD002BE)
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Internal remarks:
gastrointestinal toxicity
Endpoint study
#7: Cortinovis, Cristina., Caloni, Francesca. Epidemiology of intoxication of domestic animals by plants in Europe. veterinary journal, 2013, vol. 197, no. 2, p. 163–168. DOI: 10.1016/j.tvjl.2013.03.007.
[
DOI link]
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Study relevance:
Human health
-
Substance:
Cycasin (RF-00011099-PAR)
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Type of toxicological test:
case report (CHD060TT)
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-
Tested organism:
Dog (as animal) (A0CNL)
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-
Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
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Number of organisms dosed:
1
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Control groups used:
no data
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Endpoint measured:
Dose not reported (CHD066EP)
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Critical effect:
HEMOPOIETIC (TOX10A)
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Target tissue:
cardiovascular / haematological: Blood Coagulation (TT010A)
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Effect description:
disseminated intravascular coagulation
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Effect or parameter linked to the endpoint:
haematology (CHD023BE)
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Internal remarks:
disseminated intravascular coagulation
Endpoint study
#8: Cortinovis, Cristina., Caloni, Francesca. Epidemiology of intoxication of domestic animals by plants in Europe. veterinary journal, 2013, vol. 197, no. 2, p. 163–168. DOI: 10.1016/j.tvjl.2013.03.007.
[
DOI link]
-
Study relevance:
Human health
-
Substance:
Cycasin (RF-00011099-PAR)
-
Type of toxicological test:
case report (CHD060TT)
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-
Tested organism:
Dog (as animal) (A0CNL)
-
-
Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
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Number of organisms dosed:
1
-
Control groups used:
no data
-
Endpoint measured:
Dose not reported (CHD066EP)
-
Critical effect:
HEPATOTOXICITY (TOX02A)
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Target tissue:
digestive: Liver (TT023A)
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Effect description:
icterus (jaundice)
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Effect or parameter linked to the endpoint:
other (CHD003BE)
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Internal remarks:
hepatotoxicity
Endpoint study
#9: BOTHA, CJ., NAUDE, TW., SWAN, GE., ASHTON, MM., VANDERWATEREN, JF. SUSPECTED CYCAD (CYCAS-REVOLUTA) INTOXICATION IN DOGS. SUID-AFRIKAANSE VETERINERE VERENIGING, 1991, vol. 62, no. 4, p. 189–190. .
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Study relevance:
Human health
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Plant part:
Aerial part of plants (as part-nature) (A166F)
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Preparation/Extraction method:
Fresh (A166Y)
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Type of toxicological test:
case report (CHD060TT)
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Tested organism:
Dog (as animal) (A0CNL)
-
-
Number of organisms dosed:
3
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Endpoint measured:
Dose not reported (CHD066EP)
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Critical effect:
Digestive (TOX18A)
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Target tissue:
Digestive (TT002A)
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Effect description:
gastrointestinal toxixity; congested mucous membranes, thirst and profuse salivation
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Effect or parameter linked to the endpoint:
other (CHD003BE)
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Internal remarks:
congested mucous membranes, thirst and profuse salivation
Endpoint study
#10: BOTHA, CJ., NAUDE, TW., SWAN, GE., ASHTON, MM., VANDERWATEREN, JF. SUSPECTED CYCAD (CYCAS-REVOLUTA) INTOXICATION IN DOGS. SUID-AFRIKAANSE VETERINERE VERENIGING, 1991, vol. 62, no. 4, p. 189–190. .
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Study relevance:
Human health
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Preparation/Extraction method:
Fresh (A166Y)
-
Type of toxicological test:
case report (CHD060TT)
-
Tested organism:
Dog (as animal) (A0CNL)
-
-
Number of organisms dosed:
3
-
Endpoint measured:
Dose not reported (CHD066EP)
-
Critical effect:
Digestive (TOX18A)
-
Target tissue:
digestive: Liver (TT023A)
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Effect description:
elevated serum concentrations of alanine transaminase, an initial mild lymphocytopenia, thrombocytopenia and a leucocytosis; jaundice, liver necrosis
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Effect or parameter linked to the endpoint:
haematology (CHD023BE)
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Internal remarks:
hepatotoxicity