EFSA Compendium of Botanicals

Draft - work in progress

Zedoary (as plant) // Curcuma zedoaria (Christm.) Roscoe

Family:: Zingiberaceae
Approval state:: Approved
Number of articles retrieved:: 1479
Number of processed references:: 7

Compositions

#1: Sesquiterpene lactones #2: Labdane diterpenes #3: 1,8-Cineole #4: Camphor #5: Curzerenone #6: Curcumin and derivatives #7: epi-Curzerenone #8: Camphor #9: furanodienone #10: Camphor #11: 1,8-cineole #12: furanodiene #13: Labdane diterpenes: labda-8(17), 12 diene-15, 16 dial, zerumin A #14: Sesquiterpente lactones #15: Furanodiene

Endpoint Studies

Genotoxicity

Composition #1: Matsuda, Hisashi., Kageura, Tadashi., Morikawa, Toshio., Toguchida, Iwao., Ninomiya, Kiyofumi., Murakami, Toshiyuki., Yoshikawa, Masayuki. Research for anti-Oketsu crude drugs, Zedoariae Rhizoma, Saussureae Radix, Nupharis Rhizoma, and Rhei Rhizoma: NO production inhibitory, vasorelaxant, and hepatoprotective constituents. tennen yuki kagobutsu toronkai koen yoshishu, 1999, p. 217–222. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Additional extraction description:

unspecified
Substance:

Sesquiterpene lactones (RF-00004319-PAR)
Additional substance description:

costunolide, dehydrocostus lactone, santamarine, saussureamines A and B
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Sesquiterpene lactones

Composition #2: Lattmann, E., Sattayasai, J., Sattayasai, N., Staaf, A., Phimmasone, S., Schwalbe, C.H., Chaveerach, A. In-vitro and in-vivo antivenin activity of 2-[2-(5,5,8a-trimethyl-2- methylene-decahydro-naphthalen-1-yl)-ethylidene]-succinaldehyde against Ophiophagus hannah venom. Journal of Pharmacy and Pharmacology, 2010, vol. 62, no. 2, p. 257–262. DOI: 10.1211/jpp.62.02.0014. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Acetone
Substance:

labdane diterpenes (RF-00004392-PAR)
Additional substance description:

2-[2-(5,5,8a-trimethyl-2- methylene-decahydro-naphthalen-1-yl)-ethylidene]- succinaldehyde
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Labdane diterpenes

Composition #3: Purkayastha, J., Nath, SC., Klinkby, N. Essential oil of the rhizome of Curcuma zedoaria (Christm.) Rosc. native to northeast India . journal of essential oil research, 2006, vol. 18, no. 2, p. 154–155. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

15.9
Internal remarks:

1,8-Cineole

Composition #4: Purkayastha, J., Nath, SC., Klinkby, N. Essential oil of the rhizome of Curcuma zedoaria (Christm.) Rosc. native to northeast India . journal of essential oil research, 2006, vol. 18, no. 2, p. 154–155. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Camphor (RF-00003986-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

7.8
Internal remarks:

Camphor

Composition #5: Purkayastha, J., Nath, SC., Klinkby, N. Essential oil of the rhizome of Curcuma zedoaria (Christm.) Rosc. native to northeast India . journal of essential oil research, 2006, vol. 18, no. 2, p. 154–155. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

curzerenone (RF-00004241-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

22.3
Internal remarks:

Curzerenone

Composition #6: Peng, Chiung-Huei., Chiu, Wen-Ta., Juan, Chi-Wen., Mau, Jeng-Leun., Chen, Chien-Chou., Peng, Chiung-Chi., Lai, Eric-YC., Chyau, Charng-Cherng. Pivotal role of curcuminoids on the antimutagenic activity of Curcuma zedoaria extracts. DRUG AND CHEMICAL TOXICOLOGY, 2010, vol. 33, no. 1, p. 64–76. DOI: 10.3109/01480540903170738. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

Curcumin (RF-00000108-ADD)
Additional substance description:

Curcumin and derivatives
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Curcumin and derivatives

Composition #7: Angel, G. R., Menon, Nirmala., Vimala, B., Nambisan, Bala. Essential oil composition of eight starchy Curcuma species. INDUSTRIAL CROPS AND PRODUCTS, 2014, vol. 60, p. 233–238. DOI: 10.1016/j.indcrop.2014.06.028. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Water distillation
Substance:

curzerenone (RF-00004241-PAR)
Additional substance description:

epi-Curzerenone
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

19
Internal remarks:

epi-Curzerenone

Composition #8: Angel, G. R., Menon, Nirmala., Vimala, B., Nambisan, Bala. Essential oil composition of eight starchy Curcuma species. INDUSTRIAL CROPS AND PRODUCTS, 2014, vol. 60, p. 233–238. DOI: 10.1016/j.indcrop.2014.06.028. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Water distillation
Substance:

Camphor (RF-00003986-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.3
Internal remarks:

Camphor

Composition #9: Retnowati, Rurini., Rahman, Moh Farid., Yulia, Dore. Chemical Constituents of the Essential Oils of White Turmeric (Curcuma zedoaria (Christm.) Roscoe) from Indonesia and its Toxicity toward Artemia salina Leach. JOURNAL OF ESSENTIAL OIL BEARING PLANTS, 2014, vol. 17, no. 3, p. 393–396. DOI: 10.1080/0972060X.2014.895196. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Steam distillation
Substance:

Furanodienone (RF-00011184-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.49
Internal remarks:

furanodienone

Composition #10: Retnowati, Rurini., Rahman, Moh Farid., Yulia, Dore. Chemical Constituents of the Essential Oils of White Turmeric (Curcuma zedoaria (Christm.) Roscoe) from Indonesia and its Toxicity toward Artemia salina Leach. JOURNAL OF ESSENTIAL OIL BEARING PLANTS, 2014, vol. 17, no. 3, p. 393–396. DOI: 10.1080/0972060X.2014.895196. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Steam distillation
Substance:

Camphor (RF-00003986-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

49.51
Internal remarks:

Camphor

Composition #11: Retnowati, Rurini., Rahman, Moh Farid., Yulia, Dore. Chemical Constituents of the Essential Oils of White Turmeric (Curcuma zedoaria (Christm.) Roscoe) from Indonesia and its Toxicity toward Artemia salina Leach. JOURNAL OF ESSENTIAL OIL BEARING PLANTS, 2014, vol. 17, no. 3, p. 393–396. DOI: 10.1080/0972060X.2014.895196. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Steam distillation
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.42
Internal remarks:

1,8-cineole

Composition #12: Retnowati, Rurini., Rahman, Moh Farid., Yulia, Dore. Chemical Constituents of the Essential Oils of White Turmeric (Curcuma zedoaria (Christm.) Roscoe) from Indonesia and its Toxicity toward Artemia salina Leach. JOURNAL OF ESSENTIAL OIL BEARING PLANTS, 2014, vol. 17, no. 3, p. 393–396. DOI: 10.1080/0972060X.2014.895196. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Steam distillation
Substance:

Furanodiene (RF-00011192-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.61
Internal remarks:

furanodiene

Composition #13: Hamdi, Omer Abdalla Ahmed., Rahman, Syarifah Nur Syed Abdul., Awang, Khalijah., Wahab, Norhanom Abdul., Looi, Chung Yeng., Thomas, Noel Francis., Abd Malek, Sri Nurestri. Cytotoxic Constituents from the Rhizomes of Curcuma zedoaria. scientific world journal, 2014 . DOI: 10.1155/2014/321943. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

n-hexane
Substance:

labdane diterpenes (RF-00004392-PAR)
Additional substance description:

labda-8(17), 12 diene-15, 16 dial, zerumin A
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Labdane diterpenes: labda-8(17), 12 diene-15, 16 dial, zerumin A

Composition #14: Hamdi, Omer Abdalla Ahmed., Rahman, Syarifah Nur Syed Abdul., Awang, Khalijah., Wahab, Norhanom Abdul., Looi, Chung Yeng., Thomas, Noel Francis., Abd Malek, Sri Nurestri. Cytotoxic Constituents from the Rhizomes of Curcuma zedoaria. scientific world journal, 2014 . DOI: 10.1155/2014/321943. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

n-hexane
Substance:

Sesquiterpene lactones (RF-00004319-PAR)
Additional substance description:

zederone, curcumanolide A, curcuzedoalide, gweicurculactone
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Sesquiterpente lactones

Composition #15: Hamdi, Omer Abdalla Ahmed., Rahman, Syarifah Nur Syed Abdul., Awang, Khalijah., Wahab, Norhanom Abdul., Looi, Chung Yeng., Thomas, Noel Francis., Abd Malek, Sri Nurestri. Cytotoxic Constituents from the Rhizomes of Curcuma zedoaria. scientific world journal, 2014 . DOI: 10.1155/2014/321943. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

n-hexane
Substance:

Furanodiene (RF-00011192-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Furanodiene