EFSA Compendium of Botanicals

Draft - work in progress

Curculigo orchioides Gaertn.

Family:: Hypoxidaceae
Approval state:: Approved
Number of articles retrieved:: 498
Number of processed references:: 8

Compositions

#1: Lycorine #2: Gallic acid #3: Calcium oxalates #4: Tannins #5: Cardiac glycosides #6: Coumarins #7: Lignans #8: Saponins #9: pregnane derivatives (12α, 16β-dihydroxycycloartane-3, 24-dione) #10: Lignans #11: Saponins

Endpoint Studies

#1: abortifacient property

Genotoxicity

Composition #1: Asif, M. A review on phytochemical and ethnopharmacological activities of Curculigo orchioides. Mahidol University Journal of Pharmaceutical Sciences, 2012, p. 1–10. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane
Substance:

lycorine (RF-00003913-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lycorine

Composition #2: Shrikumar, S., Athem, M., Sukumar, M., Ravi, T.K. A HPTLC method for standardization of Curculigo orchioides rhizomes and its marketed formulation using gallic acid as standard. indian journal of pharmaceutical sciences, 2005, vol. 67, no. 6, p. 721–724. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

gallic acid (RF-00003821-PAR)
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.54
Internal remarks:

Gallic acid

Composition #3: Patil, A.G., Koli, S.P., Patil, D.A., Phatak, A.V., Chandra, N. Pharmacognostic evaluation and hptlc fingerprint profile of Curculigo orchioides Gaertn. Rhizomes. International Journal of Pharma and Bio Sciences, 2012, vol. 3, no. 3, p. P101–P111. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

Calcium oxalate (RF-00003960-PAR)
Additional substance description:

Ca oxalate
Analytical method code:

Histometrical standard tests (F097A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Calcium oxalates

Composition #4: Patil, A., Koli, S., Patil, D.A., Narayane, V., Phatak, A.V. Evaluation of effect of aqueous slurry of curculigo orchioides Gaertn. rhizome in streptozotocin-induced diabetic rats. Journal of Pharmacy Research, 2013, vol. 7, no. 8, p. 747–753. DOI: 10.1016/j.jopr.2013.08.016. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

various solvents namely water, methanol, ethanol, benzene and petroleum ether
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Analytical method - additional description:

TLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins

Composition #5: Patil, A., Koli, S., Patil, D.A., Narayane, V., Phatak, A.V. Evaluation of effect of aqueous slurry of curculigo orchioides Gaertn. rhizome in streptozotocin-induced diabetic rats. Journal of Pharmacy Research, 2013, vol. 7, no. 8, p. 747–753. DOI: 10.1016/j.jopr.2013.08.016. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

various solvents namely water, methanol, ethanol, benzene and petroleum ether
Substance:

cardiac glycosides (RF-00010823-PAR)
Analytical method code:

Phytochemical screening (F604A)
Analytical method - additional description:

TLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Cardiac glycosides

Composition #6: Patil, A., Koli, S., Patil, D.A., Narayane, V., Phatak, A.V. Evaluation of effect of aqueous slurry of curculigo orchioides Gaertn. rhizome in streptozotocin-induced diabetic rats. Journal of Pharmacy Research, 2013, vol. 7, no. 8, p. 747–753. DOI: 10.1016/j.jopr.2013.08.016. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

various solvents namely water, methanol, ethanol, benzene and petroleum ether
Substance:

coumarins (RF-00004351-PAR)
Analytical method code:

Phytochemical screening (F604A)
Analytical method - additional description:

TLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Coumarins

Composition #7: Patil, A., Koli, S., Patil, D.A., Narayane, V., Phatak, A.V. Evaluation of effect of aqueous slurry of curculigo orchioides Gaertn. rhizome in streptozotocin-induced diabetic rats. Journal of Pharmacy Research, 2013, vol. 7, no. 8, p. 747–753. DOI: 10.1016/j.jopr.2013.08.016. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

various solvents namely water, methanol, ethanol, benzene and petroleum ether
Substance:

lignans (RF-00004361-PAR)
Analytical method code:

Phytochemical screening (F604A)
Analytical method - additional description:

TLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lignans

Composition #8: Patil, A., Koli, S., Patil, D.A., Narayane, V., Phatak, A.V. Evaluation of effect of aqueous slurry of curculigo orchioides Gaertn. rhizome in streptozotocin-induced diabetic rats. Journal of Pharmacy Research, 2013, vol. 7, no. 8, p. 747–753. DOI: 10.1016/j.jopr.2013.08.016. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

various solvents namely water, methanol, ethanol, benzene and petroleum ether
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Analytical method - additional description:

TLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saponins

Composition #9: Jiao, Wei., Chen, Xiaozhen., Wang, Haibo., Lu, Runhua., Shao, Huawu. A new hepatotoxic triterpenoid ketone from Curculigo orchioides. FITOTERAPIA, 2013, vol. 84, p. 1–5. DOI: 10.1016/j.fitote.2012.10.016. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH
Substance:

pregnane derivatives (RF-00004313-PAR)
Additional substance description:

12α, 16β-dihydroxycycloartane-3, 24-dione
Analytical method code:

Chromatographic tests (F015A)
Analytical method - additional description:

IR; UV; NMR; ESI-MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

pregnane derivatives (12α, 16β-dihydroxycycloartane-3, 24-dione)

Composition #10: He, Yongjing., Dong, Xin., Jia, Xiaoxuan., Li, Mei., Yuan, Tingting., Xu, Hongtao., Qin, Luping., Han, Ting., Zhang, Qiaoyan. Qualitative and quantitative analysis on chemical constituents from Curculigo orchioides using ultra high performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry . journal of pharmaceutical and biomedical analysis, 2015, vol. 102, p. 236–245. DOI: 10.1016/j.jpba.2014.09.024. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

70% ethanol
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

Sinensigenin A, Crassifogenin A, Crassifoside I, Breviscaside A
Analytical method code:

UHPLC-MS-MS (F608A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lignans

Composition #11: XU, JP., XU, RS. CYCLOARTANE-TYPE SAPOGENINS AND THEIR GLYCOSIDES FROM CURCULIGO-ORCHIOIDES. PHYTOCHEMISTRY, 1992, vol. 31, no. 7, p. 2455–2458. DOI: 10.1016/0031-9422(92)83298-D. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH
Substance:

Saponins (RF-00004333-PAR)
Additional substance description:

Curculigosaponin K, L and M
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Analytical method - additional description:

NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saponins

Endpoint study #1: Ajesh, T.P., Krishnaraj, M.V., Prabu, M., Kumuthakalavalli, R. Herbal abortifacients used by Mannan tribes of Kerala, India. International Journal of PharmTech Research, 2012, vol. 4, no. 3, p. 1015–1017. .

Study relevance:

Human health
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Type of toxicological test:

reproduction toxicity (CHD009TT)
Tested organism:

Human (as organism) (A056J)
Sex:

Female
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

REPRODUCTIVE (TOX05A)
Target tissue:

urogenital: Uterus (TT052A)
Effect description:

The plant is on the list with abortifacient effect although no scientific evidence of this properties are reported in the manuscript
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

abortifacient property