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- Cullen drupaceum (Bunge) C.H.Stirt. // Psoralea drupacea Bunge
Cullen drupaceum (Bunge) C.H.Stirt. // Psoralea drupacea Bunge
- Family:
- Fabaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 46
- Number of processed references:
- 14
Composition #1: Kartashkina, I. N., Shamsutdinov, R. I., Shakirov, T. T. Method of isolating psoralen from roots of Psoralea drupacea.. Meditsinskaya Promyshlennost SSSR, 1966, vol. 20, no. 5, p. 38–40. .
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
60% aquous methanol
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Substance:
psoralen (RF-00004015-PAR)
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Result unit:
Gram/kilogram (G015A)
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Result expression:
Dry matter (B002A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
4
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Internal remarks:
Psoralen
Composition #2: Abubakirov, N. K., Khalmurzaev, U. F. Furocoumarins of Psoralea drupacea.. Chemistry of Natural Compounds, 1967, vol. 3, no. 2, p. 137–8. .
[
DOI link]
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Plant part:
Live plants (as part-nature) (A0BA0)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
air drying followed by methanol extraction
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Substance:
angelicin (RF-00004146-PAR)
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Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
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Analytical method - additional description:
also UV and IR spectra
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
angelicin (furanocoumarin)
Composition #3: Abubakirov, N. K., Khalmurzaev, U. F. Furocoumarins of Psoralea drupacea.. Chemistry of Natural Compounds, 1967, vol. 3, no. 2, p. 137–8. .
[
DOI link]
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Plant part:
Live plants (as part-nature) (A0BA0)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
air drying followed by methanol extraction, further extraction and drying
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Substance:
Furanocoumarins (RF-00004381-PAR)
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Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
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Analytical method - additional description:
UV and IR spectra
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
<1.36
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Internal remarks:
furanocoumarins
Composition #4: Abubakirov, N. K., Khalmurzaev, U. F. Furocoumarins of Psoralea drupacea.. Chemistry of Natural Compounds, 1967, vol. 3, no. 2, p. 137–8. .
[
DOI link]
-
-
Plant part:
Live plants (as part-nature) (A0BA0)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
air drying followed by methanol extraction
-
Substance:
psoralen (RF-00004015-PAR)
-
Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
-
Analytical method - additional description:
also UV and IR spectra
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
psoralen (furanocoumarin)
Composition #5: Usmanov, B. Z., Abubakirov, N. K. Separate determination of furocoumarins of Psoralea drupaceae.. Khimiko-Farmatsevticheskii Zhurnal, 1967, vol. 1, no. 5, p. 42–6. .
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Plant part:
Seed (as part-nature) (A066P)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Ethanolic extract
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Substance:
psoralen (RF-00004015-PAR)
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Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
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Result unit:
Percent (G138A)
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Result expression:
Dry matter (B002A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
0.40
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Internal remarks:
Psoralen (in seeds)
Composition #6: Usmanov, B. Z., Abubakirov, N. K. Separate determination of furocoumarins of Psoralea drupaceae.. Khimiko-Farmatsevticheskii Zhurnal, 1967, vol. 1, no. 5, p. 42–6. .
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
ethanolic extract
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Substance:
psoralen (RF-00004015-PAR)
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Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
-
Result unit:
Percent (G138A)
-
Result expression:
Dry matter (B002A)
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Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.03
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Internal remarks:
Psoralen (in leaves)
Composition #7: Usmanov, B. Z., Abubakirov, N. K. Separate determination of furocoumarins of Psoralea drupaceae.. Khimiko-Farmatsevticheskii Zhurnal, 1967, vol. 1, no. 5, p. 42–6. .
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ethanolic extraction
-
Substance:
psoralen (RF-00004015-PAR)
-
Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
-
Result unit:
Percent (G138A)
-
Result expression:
Dry matter (B002A)
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Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.17
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Internal remarks:
Psoralen (in root)
Composition #8: Usmanov, B. Z., Abubakirov, N. K. Separate determination of furocoumarins of Psoralea drupaceae.. Khimiko-Farmatsevticheskii Zhurnal, 1967, vol. 1, no. 5, p. 42–6. .
-
-
Plant part:
Seed (as part-nature) (A066P)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ethanolic extract
-
Substance:
angelicin (RF-00004146-PAR)
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Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
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Result unit:
Percent (G138A)
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Result expression:
Dry matter (B002A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
0.52
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Internal remarks:
Angelicin (in seeds)
Composition #9: Usmanov, B. Z., Abubakirov, N. K. Separate determination of furocoumarins of Psoralea drupaceae.. Khimiko-Farmatsevticheskii Zhurnal, 1967, vol. 1, no. 5, p. 42–6. .
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-
Plant part:
Leaves (as part-nature) (A0EKT)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ethanol
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Substance:
angelicin (RF-00004146-PAR)
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Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
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Result unit:
Percent (G138A)
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Result expression:
Dry matter (B002A)
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Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.03
-
Internal remarks:
Angelicin (in leaves)
Composition #10: Usmanov, B. Z., Abubakirov, N. K. Separate determination of furocoumarins of Psoralea drupaceae.. Khimiko-Farmatsevticheskii Zhurnal, 1967, vol. 1, no. 5, p. 42–6. .
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ethanol
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Substance:
angelicin (RF-00004146-PAR)
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Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
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Result unit:
Percent (G138A)
-
Result expression:
Dry matter (B002A)
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Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.18
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Internal remarks:
Angelicin (in root)
Composition #11: Arutyunyants, S. I., Baimuradov, T. B., Rogozhin, P. S. Instance of Psoralea poisoning of swine.. Veterinariya (Moscow, Russian Federation), 1972, vol. 49, no. 8, p. 95–6. .
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Plant part:
Seed (as part-nature) (A066P)
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Substance:
Drupacine (RF-00011030-PAR)
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Additional substance description:
drupacin (a propenoic acid)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
drupacin (a propenoic acid derivative)
Composition #12: Golovina, L. A., Nikonov, G. K. The structure of drupanol - A new phenol of Psoralea drupaceae.. Chemistry of Natural Compounds 1973, vol. 9, no. 1, p. 7–9. .
[
DOI link]
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Plant part:
Fruit unspecified (as part-nature) (A067D)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
methanol extraction
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Substance:
bakuchiol (RF-00011223-PAR)
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Additional substance description:
synonym: drupanol
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Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
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Analytical method - additional description:
IR, NMR
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Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
bakuchiol (syn. drupanol)
Composition #13: Golovina, L. A., Nikonov, G. K. Structure of drupacine and drupanine, new components of Psoralea drupaceae.. Khimiya Prirodnykh Soedinenii, 1973, no. 6, p. 700–3. .
[
DOI link]
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-
Plant part:
Fruit unspecified (as part-nature) (A067D)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ether extract
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Substance:
Drupacine (RF-00011030-PAR)
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Additional substance description:
propenic acid derivative
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Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
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Analytical method - additional description:
IR, UV spectroscopy
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Result unit:
Percent (G138A)
-
Result expression:
Dry matter (B002A)
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Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.03
-
Internal remarks:
Drupacin (propenoic acid derivative)
Composition #14: Golovina, L. A., Nikonov, G. K. Structure of drupacine and drupanine, new components of Psoralea drupaceae.. Khimiya Prirodnykh Soedinenii, 1973, no. 6, p. 700–3. .
[
DOI link]
-
-
Plant part:
Fruit unspecified (as part-nature) (A067D)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ether extract
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Substance:
Drupanin (RF-00011224-PAR)
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Additional substance description:
propenoic acid derivative
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Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
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Analytical method - additional description:
IR, UV spectra
-
Result unit:
Percent (G138A)
-
Result expression:
Dry matter (B002A)
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Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.035
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Internal remarks:
Drupanin (propenic acid derivative)
Composition #15: Fedorin, G. F., Georgievskii, V. P., Komissarenko, N. F., Beletskii, Yu. N. Comparative content of psoralen and other furocoumarins in raw materials from Coronilla scorpioides, Psoralea drupacea, and Ficus carica.. Rastitel'nye Resursy, 1975, vol. 11, no. 3, p. 372–3. .
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Plant part:
Fruit unspecified (as part-nature) (A067D)
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Substance:
psoralen (RF-00004015-PAR)
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Additional substance description:
psoralen (furanocoumarin)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
psoralen (furanocoumarin)
Composition #16: Fedorin, G. F., Georgievskii, V. P., Komissarenko, N. F., Beletskii, Yu. N. Comparative content of psoralen and other furocoumarins in raw materials from Coronilla scorpioides, Psoralea drupacea, and Ficus carica.. Rastitel'nye Resursy, 1975, vol. 11, no. 3, p. 372–3. .
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Plant part:
Fruit unspecified (as part-nature) (A067D)
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Substance:
angelicin (RF-00004146-PAR)
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Additional substance description:
furanocoumarin
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Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
angelicin (furanocoumarin)
Composition #17: Kurmukov, A. G., Akhmedkhodzhaeva, Kh. S., Sidyakin, V. G., Syrov, V. N. Phytoestrogens from plants of Central Asia.. Rastitel'nye Resursy, 1976, vol. 12, no. 4, p. 515–25. .
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Plant part:
Unspecified (A07XD)
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Substance:
psoralen (RF-00004015-PAR)
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Additional substance description:
(misspelled as 'psoralem')
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Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
psoralen (furanocoumarin)
Composition #18: Bondarenko, A. S., Aizenman, B. E., Zatula, D. G., Bakina, L. A., Kozhina, I. S., Prikhod'ko, V. A., Silkina, O. V., Meshcheryakov, A. A. Psoralea drupacea Bunge as a promising source of the antibiotic Bakuchiol.. Rastitel'nye Resursy, 1977, vol. 13, no. 3, p. 460–3. .
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Plant part:
Aerial part of plants (as part-nature) (A166F)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
chloroform/acetone
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Substance:
bakuchiol (RF-00011223-PAR)
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Additional substance description:
synonym drupanol
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Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
bakuchiol (syn. drupanol)
Composition #19: Karryev, M. O., Komissarenko, N. F. Furocoumarin-containing vegetation of Turkmen SSR.. Izvestiya Akademii Nauk Turkmenskoi SSR, Seriya Biologicheskikh Nauk, 1981, no. 1, p. 65–9. .
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Plant part:
Unspecified (A07XD)
-
Substance:
Furanocoumarins (RF-00004381-PAR)
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Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Furanocoumarins
Composition #20: Karryev, M. O., Komissarenko, N. F. Furocoumarin-containing vegetation of Turkmen SSR.. Izvestiya Akademii Nauk Turkmenskoi SSR, Seriya Biologicheskikh Nauk, 1981, no. 1, p. 65–9. .
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Plant part:
Unspecified (A07XD)
-
Substance:
coumarins (RF-00004351-PAR)
-
Additional substance description:
e.g. scopoletin
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Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Coumarins (e.g. scopoletin)
Composition #21: Smirnov, V. V., Romanenko, V. M., Prikhod'ko, V. A. Effect of bakuchiol on ultrastructure of Staphylococcus aureus 209 cells.. Mikrobiologicheskii Zhurnal (1978-1993), 1984, vol. 46, no. 5, p. 72–4. .
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Plant part:
Unspecified (A07XD)
-
Substance:
bakuchiol (RF-00011223-PAR)
-
Additional substance description:
synonym drupanol
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
bakuchiol (syn. drupanol)
Composition #22: Nikonov, G. K., Artamonova, N. A. Phenolic components of the nonsaponifiable fraction of Psoralea drupacea.. Khimiya Prirodnykh Soedinenii, 1993, no. 2, p. 300–1. .
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Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Substance:
Furanocoumarins (RF-00004381-PAR)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Furanocoumarins
Composition #23: Nikonov, G. K., Artamonova, N. A. Phenolic components of the nonsaponifiable fraction of Psoralea drupacea.. Khimiya Prirodnykh Soedinenii, 1993, no. 2, p. 300–1. .
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Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Substance:
coumarins (RF-00004351-PAR)
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Additional substance description:
coumarin, 4-hydroxycoumarin
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Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
coumarins
Composition #24: Yuldashev, M. P., Batirov, E. Kh., Malikov, V. M., Yuldasheva, N. P. Flavonoids of Psoralea drupaceae and Reseda luteola.. khimiya prirodnykh soedinenii, 1996, no. 6, p. 949–951. .
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Ethanolic extract
-
Substance:
daidzein (RF-00000061-NTR)
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Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
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Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
daidzein (root)
Composition #25: Shakirov, T.T., Kartashkina, I.N., Shamsutdinov, M.R.I. Technology of the extraction of psoralene from seeds of Psoralea drupacea BGE. pharmaceutical chemistry journal, 1968, vol. 1, no. 4, p. 224–225. DOI: 10.1007/BF00770196.
[
DOI link]
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-
Plant part:
Seed (as part-nature) (A066P)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
aqueous acetone
-
Substance:
psoralen (RF-00004015-PAR)
-
Analytical method code:
Classification not possible (F001A)
-
Analytical method - additional description:
solvent extraction, evaporation, crystallisation, recrystallisation ...
-
Result unit:
Percent (G138A)
-
Result expression:
Whole weight (B001A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.7
-
Internal remarks:
Psoralen (seed)
Endpoint study
#1: Arutyunyants, S. I., Baimuradov, T. B., Rogozhin, P. S. Instance of Psoralea poisoning of swine.. Veterinariya (Moscow, Russian Federation), 1972, vol. 49, no. 8, p. 95–6. .
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Study relevance:
Human health
-
Substance:
Drupacine (RF-00011030-PAR)
-
Plant part:
Seed (as part-nature) (A066P)
-
Type of toxicological test:
case report (CHD060TT)
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Limit test:
Not applicable
-
Tested organism:
Pig (as animal) (A057F)
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-
Route of exposure:
ORAL: FEED (OECD2230PL)
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Control groups used:
no data
-
Endpoint measured:
Dose not reported (CHD066EP)
-
Critical effect:
NEUROTOXICITY (TOX04A)
-
Target tissue:
neurologic: Central Nervous System (TT035A)
-
Effect description:
disturbances of CNS and cardiac activity, gangrene of ear skin, 10-15% mortality
-
Effect or parameter linked to the endpoint:
neurology (CHD027BE)
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Internal remarks:
Case report linked to drupacin in seeds of Cullen drupaceum