EFSA Compendium of Botanicals

Draft - work in progress

Cruciata laevipes Opiz. // Galium cruciata (L.) Scop.

Family:: Rubiaceae
Approval state:: Approved
Number of articles retrieved:: 21
Number of processed references:: 4

Compositions

#1: Tannins #2: Coumarins #3: Umbelliferone #4: Scopoletin #5: Eugenol #6: Epoxylinalool #7: Daphnin (coumarin) #8: Daphnetin glucoside (coumarin)

Endpoint Studies

Genotoxicity

Composition #1: Borisov, M. I., Borisyuk, Yu. G. Phytochemical investigation of Galium cruciata. Farmatsevtichnii Zhurnal (Kiev), 1965, p. 63–66. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Substance:

Tannins (RF-00004337-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins

Composition #2: Borisov, M. I., Borisyuk, Yu. G. Phytochemical investigation of Galium cruciata. Farmatsevtichnii Zhurnal (Kiev), 1965, p. 63–66. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Substance:

coumarins (RF-00004351-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Coumarins

Composition #3: Borisov, M. I. Coumarins of the genus Asperula and Galium. Khimiya Prirodnykh Soedinenii, 1974 . .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

umbelliferone (RF-00004096-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

IR, melting point confirmation
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Umbelliferone

Composition #4: Borisov, M. I. Coumarins of the genus Asperula and Galium. Khimiya Prirodnykh Soedinenii, 1974 . .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

scopoletin (RF-00004048-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

IR, melting point confirmation
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Scopoletin

Composition #5: Il'ina, T. V., Kovaleva, A. M., Goryachaya, O. V., Vinogradov, B. A. Terpenoids and aromatic compounds from essential oils of Cruciata laevipes and C. glabra. CHEMISTRY OF NATURAL COMPOUNDS, 2013, vol. 48, no. 6, p. 1106–1108. DOI: 10.1007/s10600-013-0482-7. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Eugenol (RF-00003807-PAR)
Analytical method code:

LC-MS (F026A)
Result unit:

Gram/100 gram (G013A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.8
Internal remarks:

Eugenol

Composition #6: Il'ina, T. V., Kovaleva, A. M., Goryachaya, O. V., Vinogradov, B. A. Terpenoids and aromatic compounds from essential oils of Cruciata laevipes and C. glabra. CHEMISTRY OF NATURAL COMPOUNDS, 2013, vol. 48, no. 6, p. 1106–1108. DOI: 10.1007/s10600-013-0482-7. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

epoxides (RF-00010829-PAR)
Additional substance description:

1,2-Epoxylinalool
Analytical method code:

LC-MS (F026A)
Result unit:

Gram/100 gram (G013A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.1
Internal remarks:

Epoxylinalool

Composition #7: Mitova, MI., Anchev, ME., Panev, SG., Handjieva, NV., Popov, SS. Coumarins and iridoids from Crucianella graeca, Cruciata glabra, Cruciata laevipes and Cruciata pedemontana (Rubiaceae). ZEITSCHRIFT FUR NATURFORSCHUNG C-A JOURNAL OF BIOSCIENCES, 1996, vol. 51, no. 9-10, p. 631–634. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol extraction
Substance:

daphnin (RF-00004251-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Daphnin (coumarin)

Composition #8: Mitova, MI., Anchev, ME., Panev, SG., Handjieva, NV., Popov, SS. Coumarins and iridoids from Crucianella graeca, Cruciata glabra, Cruciata laevipes and Cruciata pedemontana (Rubiaceae). ZEITSCHRIFT FUR NATURFORSCHUNG C-A JOURNAL OF BIOSCIENCES, 1996, vol. 51, no. 9-10, p. 631–634. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol extraction
Substance:

Daphnetin glucoside (RF-00010998-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Daphnetin glucoside (coumarin)