EFSA Compendium of Botanicals

Draft - work in progress

Cotinus coggygria Scop.

Family:: Anacardiaceae
Approval state:: Approved
Number of articles retrieved:: 379
Number of processed references:: 3

Compositions

Endpoint Studies

Genotoxicity

#1: 5% methanolic extract of Cotinus coggygria induced significant mutations in X chromosome of Drosophila melanogaster males

Composition #1: Hethelyi, Mrs. Ivan., Domokos, J., Lemberkovics, Eva., Verzar-Petri, Gizella. Analysis of the essential oil of Cotinus coggygria by means of mass spectrometry (GC/MS). herba hungarica, 1986, p. 135–148. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.4-3.3
Internal remarks:

Myrcene

Composition #2: Antal, Diana S., Schwaiger, Stefan., Ellmerer-Mueller, Ernst P., Stuppner, Hermann. Cotinus coggygria Wood: Novel Flavanone Dimer and Development of an HPLC/UV/MS Method for the Simultaneous Determination of Fourteen Phenolic Constituents. PLANTA MEDICA, 2010, vol. 76, no. 15, p. 1765–1772. DOI: 10.1055/s-0030-1249878. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

gallic acid (RF-00003821-PAR)
Analytical method code:

HPLC with standard detection methods (F019A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.058-0.131
Internal remarks:

Gallic acid

Genotox #1: Stanic, S., Matic, S., Delic, G., Mihailovic, M., Bogojevic, D., Solujic, S. Study of genotoxicity and antigenotoxicity of the Cotinus coggygria Scop. methanol extract by Drosophila melanogaster sex-linked recessive lethal test. RUSSIAN JOURNAL OF GENETICS, 2011, vol. 47, no. 7, p. 770–774. DOI: 10.1134/S1022795411070167. [DOI link]

Study category:

Genotoxicity
Type of toxicological test:

Drosophila SLRL test (CHD042TT)
Method type:

in vivo
Tested organism:

Drosophila melanogaster (as animal) (A0CMC)
Sex:

Male
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Exposure duration for in vivo:

24.0
Unit of exposure duration:

Hour (G099A)
Endpoint measured:

gene mutation
Is genotoxic:

Positive
Remarks on genotox study:

5% methanolic extract of Cotinus coggygria induced significant mutations in X chromosome of Drosophila melanogaster males
Internal remarks:

5% methanolic extract of Cotinus coggygria induced significant mutations in X chromosome of Drosophila melanogaster males
Internal ID:

WOS:000292886800002