EFSA Compendium of Botanicals

Draft - work in progress

Coscinium fenestratum (Goetgh.) Colebr.

Family:: Menispermaceae
Approval state:: Approved
Number of articles retrieved:: 165
Number of processed references:: 8

Compositions

#1: berberine #2: berberine #3: berberine #4: berberine #5: berberine #6: Bisbenzylisoquinoline alkaloids #7: Bisbenzylisoquinoline alkaloids

Endpoint Studies

#1: Neurotoxicity in rats

Genotoxicity

Composition #1: Rojsanga, P., Gritsanapan, W. Variation of berberine content in Coscinium fenestratum stem in Thailand markets. Warasan Phesatchasat, 2005, p. 66–70. .

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol 80%
Substance:

berberine (RF-00003706-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

11.84-18.45
Internal remarks:

berberine

Composition #2: Babu, Ramesh., Thriveni, H. N., Vasudeva, R. Influence of drying methods and extraction procedures on the recovery of berberine content in Coscinium fenestratum. Journal of Natural Product and Plant Resources, 2012, p. 540–544. .

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

berberine (RF-00003706-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

<=4.06
Internal remarks:

berberine

Composition #3: Ldam, Arawwawala., Wan, Wickramaarachchi. Berberine content in Coscinium fenestratum grown in Sri Lanka. Research Reviews: Journal of Botanical Sciences, 2012, p. 1–4. .

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

berberine (RF-00003706-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

berberine

Composition #4: Chitra, K., Sujatha, K., Polisetti, H., Karri, S., Umamaheswara Reddy, C. Standardization of Coscinium fenestratum with reference to berberine by high performance thin layer chromatography. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 2011, vol. 2, no. 2, p. 226–229. .

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Chloroform
Substance:

berberine (RF-00003706-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

4.67
Internal remarks:

berberine

Composition #5: Rojsanga, Piyanuch., Gritsanapan, Wandee., Suntornsuk, Leena. Determination of berberine content in the stem extracts of Coscinium fenestratum by TLC densitometry. MEDICAL PRINCIPLES AND PRACTICE, 2006, vol. 15, no. 5, p. 373–378. DOI: 10.1159/000094272. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

berberine (RF-00003706-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

TLC
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.67-3.37
Internal remarks:

berberine

Composition #6: Deevanhxay, Phengxay., Suzuki, Makoto., Maeshibu, Nariaki., Li, He., Tanaka, Ken., Hirose, Sachio. Simultaneous characterization of quaternary alkaloids, 8-oxoprotoberberine alkaloids, and a steroid compound in Coscinium fenestratum by liquid chromatography hybrid ion trap time-of-flight mass spectrometry. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2009, vol. 50, no. 3, p. 413–425. DOI: 10.1016/j.jpba.2009.05.023. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Bisbenzylisoquinoline alkaloids (RF-00010792-PAR)
Analytical method code:

LC-MS (F026A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Bisbenzylisoquinoline alkaloids

Composition #7: PINHO, PMM., PINTO, MMM., KIJJOA, A., PHARADAI, K., DIAZ, JG., HERZ, W. PROTOBERBERINE ALKALOIDS FROM COSCINIUM-FENESTRATUM. PHYTOCHEMISTRY, 1992, vol. 31, no. 4, p. 1403–1407. DOI: 10.1016/0031-9422(92)80301-T. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

Bisbenzylisoquinoline alkaloids (RF-00010792-PAR)
Additional substance description:

oxypalmatine, (-)-8-oxotetrahydrothalifendine, (-)-8-oxoisocorypalmine, berberine and (-)-8-oxocanadine
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

C NMR, TLC, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Bisbenzylisoquinoline alkaloids

Endpoint study #1: Wattanathorn, Jintanaporn., Uabundit, Nongnut., Itarat, Wanchai., Mucimapura, Supaporn., Laopatarakasem, Pisamai., Sripanidkulchai, Bungorn. Neurotoxicity of Coscinium fenestratum stem, a medicinal plant used in traditional medicine. FOOD AND CHEMICAL TOXICOLOGY, 2006, vol. 44, no. 8, p. 1327–1333. DOI: 10.1016/j.fct.2006.02.012. [DOI link]

Study relevance:

Human health
Plant part:

Stem / stalk (as part-nature) (A067S)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

Ethanol
Type of toxicological test:

short-term toxicity (CHD017TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Sprague-Dawley (CHD012ST)
Sex:

Male
Route of exposure:

ORAL: FEED (OECD2230PL)
Exposure duration:

14.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

32
Control groups used:

yes
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligram/kilogram (G061A)
Effect concentration:

5-20
Critical effect:

NEUROTOXICITY (TOX04A)
Target tissue:

neurologic: Brain (TT034A)
Effect description:

induced neurotoxicity in cerebral cortex, striatum and hippocampus and also increased stereotype behaviors.
Effect or parameter linked to the endpoint:

neurology (CHD027BE)
Internal remarks:

Neurotoxicity in rats