EFSA Compendium of Botanicals

Draft - work in progress

Corydalis intermedia (L.) Merat.

Family:: Papaveraceae
Approval state:: Approved
Number of articles retrieved:: 26
Number of processed references:: 2

Compositions

#1: Protopine #2: Isoquinoline alkaloids #3: Bicuculline #4: Isoquinoline alkaloids #5: allocryptopine #6: protopine #7: tetrahydropalmatine

Endpoint Studies

Genotoxicity

Composition #1: Slavik, Jiri., Slavikova, Leonora. Alkaloids of the Papaveraceae. Part IXC. Alkaloids from Corydalis nobilis (L.) Pers. and C. intermedia (L.) Merat. collection of czechoslovak chemical communications, 1989, p. 2009–2020. .

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

protopine (RF-00004010-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.16
Internal remarks:

Protopine

Composition #2: Slavik, Jiri., Slavikova, Leonora. Alkaloids of the Papaveraceae. Part IXC. Alkaloids from Corydalis nobilis (L.) Pers. and C. intermedia (L.) Merat. collection of czechoslovak chemical communications, 1989, p. 2009–2020. .

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

Tetrahydropalmatine, palmatine, dehydrocorydaline, berberine and coptisine
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isoquinoline alkaloids

Composition #3: Slavik, Jiri., Slavikova, Leonora. Alkaloids of the Papaveraceae. Part IXC. Alkaloids from Corydalis nobilis (L.) Pers. and C. intermedia (L.) Merat. collection of czechoslovak chemical communications, 1989, p. 2009–2020. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Bicuculline (RF-00004181-PAR)
Additional substance description:

Bicuculline
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.14
Internal remarks:

Bicuculline

Composition #4: Slavik, Jiri., Slavikova, Leonora. Alkaloids of the Papaveraceae. Part IXC. Alkaloids from Corydalis nobilis (L.) Pers. and C. intermedia (L.) Merat. collection of czechoslovak chemical communications, 1989, p. 2009–2020. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

Stylopine, protopine, allocryptopine, canadine, corydaline, bulbocapnine, coptisine, palmatine and berberine
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isoquinoline alkaloids

Composition #5: Sturm, Sonja., Seger, Christoph., Stuppner, Hermann. Analysis of Central European Corydalis species by nonaqueous capillary electrophoresis-electrospray ion trap mass spectrometry . journal of chromatography a, 2007, vol. 1159, no. 1-2, p. 42–50. DOI: 10.1016/j.chroma.2007.02.108. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol extraction
Substance:

allocryptopine (RF-00004136-PAR)
Analytical method code:

Mass Spectroscopy and hyphenated methods without chromatography (F063A)
Analytical method - additional description:

electrophoresis-electrospray ion trap mass spectrometry (NACE-ESI-MS)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.24-1.08
Internal remarks:

allocryptopine

Composition #6: Sturm, Sonja., Seger, Christoph., Stuppner, Hermann. Analysis of Central European Corydalis species by nonaqueous capillary electrophoresis-electrospray ion trap mass spectrometry . journal of chromatography a, 2007, vol. 1159, no. 1-2, p. 42–50. DOI: 10.1016/j.chroma.2007.02.108. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol extraction
Substance:

protopine (RF-00004010-PAR)
Analytical method code:

Mass Spectroscopy and hyphenated methods without chromatography (F063A)
Analytical method - additional description:

electrophoresis-electrospray ion trap mass spectrometry (NACE-ESI-MS)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.92-3.84
Internal remarks:

protopine

Composition #7: Sturm, Sonja., Seger, Christoph., Stuppner, Hermann. Analysis of Central European Corydalis species by nonaqueous capillary electrophoresis-electrospray ion trap mass spectrometry . journal of chromatography a, 2007, vol. 1159, no. 1-2, p. 42–50. DOI: 10.1016/j.chroma.2007.02.108. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol extraction
Substance:

tetrahydropalmatin (RF-00003602-PAR)
Analytical method code:

Mass Spectroscopy and hyphenated methods without chromatography (F063A)
Analytical method - additional description:

electrophoresis-electrospray ion trap mass spectrometry (NACE-ESI-MS)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.84-1.80
Internal remarks:

tetrahydropalmatine