EFSA Compendium of Botanicals

Draft - work in progress

Cordia curassavica (Jacq.) Roem. & Schult. // Cordia verbenacea A.DC.

Family:: Boraginaceae
Approval state:: Approved
Number of articles retrieved:: 175
Number of processed references:: 1

Compositions

Endpoint Studies

Genotoxicity

Composition #1: Coe, F.G., Parikh, D.M., Johnson, C.A., Anderson, G.J. The good and the bad: Alkaloid screening and brineshrimp bioassays of aqueous extracts of 31 medicinal plants of eastern Nicaragua. pharmaceutical biology, 2012, vol. 50, no. 3, p. 384–392. DOI: 10.3109/13880209.2011.608077. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

chloroform
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Chromatographic tests (F015A)
Analytical method - additional description:

TLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids

Endpoint study #1: Coe, F.G., Parikh, D.M., Johnson, C.A., Anderson, G.J. The good and the bad: Alkaloid screening and brineshrimp bioassays of aqueous extracts of 31 medicinal plants of eastern Nicaragua. pharmaceutical biology, 2012, vol. 50, no. 3, p. 384–392. DOI: 10.3109/13880209.2011.608077. [DOI link]

Study relevance:

Human health
Plant part:

Live plants (as part-nature) (A0BA0)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

water extract (boiled water)
Type of toxicological test:

acute toxicity (CHD016TT)
Tested organism:

Brine shrimp (as animal) (A0YSQ)
Route of exposure:

OTHER (OECD0PL)
Number of organisms dosed:

10
Endpoint measured:

Concentration producing lethality in 50% of experimental organisms (CHD023EP)
Concentration unit:

Microgram/millilitre (G052A)
Effect concentration:

2280
Critical effect:

NONE (TOX14A)
Effect description:

LC50 = 2280 microgram/mL
Effect or parameter linked to the endpoint:

mortality (CHD010BE)
Internal remarks:

LC50 brineshrimps test