EFSA Compendium of Botanicals

Draft - work in progress

Coptis teeta Wall.

Family:: Ranunculaceae
Approval state:: Approved
Number of articles retrieved:: 139
Number of processed references:: 5

Compositions

#1: berberine #2: coptisine #3: Palmatine #4: lariciresinol #5: protocatechuic acid #6: berberine in wild C. teeta #7: berberine in cultivated C. teeta #8: Jateorrhizine #9: Columbamine #10: Coptisine #11: Palmatine #12: Berberine #13: Jatrorrhizine #14: epiberberine #15: Columbamine

Endpoint Studies

Genotoxicity

Composition #1: Li, Chia-Ying., Tsai, Sung-I., Damu, Amooru G., Wu, Tian-Shung. A rapid and simple determination of protoberberine alkaloids in Rhizoma Coptidis by 1H NMR and its application for quality control of commercial prescriptions. Journal of Pharmaceutical and Biomedical Analysis, 2009, p. 1272–1276. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

berberine (RF-00003706-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

H NMR
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

11.71
Internal remarks:

berberine

Composition #2: Li, Chia-Ying., Tsai, Sung-I., Damu, Amooru G., Wu, Tian-Shung. A rapid and simple determination of protoberberine alkaloids in Rhizoma Coptidis by 1H NMR and its application for quality control of commercial prescriptions. Journal of Pharmaceutical and Biomedical Analysis, 2009, p. 1272–1276. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

coptisine (RF-00004215-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

H NMR
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.98
Internal remarks:

coptisine

Composition #3: Li, Chia-Ying., Tsai, Sung-I., Damu, Amooru G., Wu, Tian-Shung. A rapid and simple determination of protoberberine alkaloids in Rhizoma Coptidis by 1H NMR and its application for quality control of commercial prescriptions. Journal of Pharmaceutical and Biomedical Analysis, 2009, p. 1272–1276. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

palmatine (RF-00003971-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

H NMR
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.66
Internal remarks:

Palmatine

Composition #4: Meng, F., Wang, L., Zhang, J., Yin, Z., Zhang, Q., Ye, W. Non-alkaloid chemical constituents from the rhizome of Coptis teeta. journal of china pharmaceutical university, 2013, vol. 44, no. 4, p. 307–310. DOI: 10.11665/j.issn.1000-5048.20130404. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

lariciresinol (RF-00011086-PAR)
Analytical method code:

Chromatographic tests (F015A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

lariciresinol

Composition #5: Meng, F., Wang, L., Zhang, J., Yin, Z., Zhang, Q., Ye, W. Non-alkaloid chemical constituents from the rhizome of Coptis teeta. journal of china pharmaceutical university, 2013, vol. 44, no. 4, p. 307–310. DOI: 10.11665/j.issn.1000-5048.20130404. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

3,4-Dihydroxybenzoic acid (RF-00008853-PAR)
Analytical method code:

Chromatographic tests (F015A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

protocatechuic acid

Composition #6: Zhang, Ji., Cai, Chuan-Tao., Cai, Zhi-Quan., Liu, Gui-Zhou., Luo, Yuan., Yang, Zhi-Xiong. Variation patterns of Coptis teeta biomass and its major active compounds along an altitude gradient . . ying yong sheng tai xue bao = the journal of applied ecology / zhongguo sheng tai xue xue hui, zhongguo ke xue yuan shenyang ying yong sheng tai yan jiu suo zhu ban, 2008, vol. 19, no. 7, p. 1455–61. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Substance:

berberine (RF-00003706-PAR)
Additional substance description:

wild C. teeta
Analytical method code:

Unspecified (F598A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.93-4.60
Internal remarks:

berberine in wild C. teeta

Composition #7: Zhang, Ji., Cai, Chuan-Tao., Cai, Zhi-Quan., Liu, Gui-Zhou., Luo, Yuan., Yang, Zhi-Xiong. Variation patterns of Coptis teeta biomass and its major active compounds along an altitude gradient . . ying yong sheng tai xue bao = the journal of applied ecology / zhongguo sheng tai xue xue hui, zhongguo ke xue yuan shenyang ying yong sheng tai yan jiu suo zhu ban, 2008, vol. 19, no. 7, p. 1455–61. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Substance:

berberine (RF-00003706-PAR)
Additional substance description:

cultivated C. teeta
Analytical method code:

Unspecified (F598A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.90-4.41
Internal remarks:

berberine in cultivated C. teeta

Composition #8: Fan, Gang., Tao, Ling-hui., Yue, Qing-hong., Kuang, Ting-ting., Tang, Ce., Yang, Yong-dong., Luo, Wei-zao., Zhou, Xiang-dong., Zhang, Yi. Metabolic Discrimination of Rhizoma Coptidis from Different Species Using H-1 NMR Spectroscopy and Principal Component Analysis . planta medica, 2012, vol. 78, no. 6, p. 641–648. DOI: 10.1055/s-0031-1298240. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CD3OD (chloroform deutere)
Substance:

jatrorrhizine (RF-00003887-PAR)
Additional substance description:

Jateorrhizine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

HPLC and NMR
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

circa 8
Internal remarks:

Jateorrhizine

Composition #9: Fan, Gang., Tao, Ling-hui., Yue, Qing-hong., Kuang, Ting-ting., Tang, Ce., Yang, Yong-dong., Luo, Wei-zao., Zhou, Xiang-dong., Zhang, Yi. Metabolic Discrimination of Rhizoma Coptidis from Different Species Using H-1 NMR Spectroscopy and Principal Component Analysis . planta medica, 2012, vol. 78, no. 6, p. 641–648. DOI: 10.1055/s-0031-1298240. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CD3OD (chloroform deutere)
Substance:

columbamine (RF-00011147-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

HPLC and NMR
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

circa 2
Internal remarks:

Columbamine

Composition #10: Fan, Gang., Tao, Ling-hui., Yue, Qing-hong., Kuang, Ting-ting., Tang, Ce., Yang, Yong-dong., Luo, Wei-zao., Zhou, Xiang-dong., Zhang, Yi. Metabolic Discrimination of Rhizoma Coptidis from Different Species Using H-1 NMR Spectroscopy and Principal Component Analysis . planta medica, 2012, vol. 78, no. 6, p. 641–648. DOI: 10.1055/s-0031-1298240. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CD3OD (chloroform deutere)
Substance:

coptisine (RF-00004215-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

HPLC and NMR
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

circa 14
Internal remarks:

Coptisine

Composition #11: Fan, Gang., Tao, Ling-hui., Yue, Qing-hong., Kuang, Ting-ting., Tang, Ce., Yang, Yong-dong., Luo, Wei-zao., Zhou, Xiang-dong., Zhang, Yi. Metabolic Discrimination of Rhizoma Coptidis from Different Species Using H-1 NMR Spectroscopy and Principal Component Analysis . planta medica, 2012, vol. 78, no. 6, p. 641–648. DOI: 10.1055/s-0031-1298240. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CD3OD (chloroform deutere)
Substance:

palmatine (RF-00003971-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

HPLC and NMR
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

circa 5
Internal remarks:

Palmatine

Composition #12: Fan, Gang., Tao, Ling-hui., Yue, Qing-hong., Kuang, Ting-ting., Tang, Ce., Yang, Yong-dong., Luo, Wei-zao., Zhou, Xiang-dong., Zhang, Yi. Metabolic Discrimination of Rhizoma Coptidis from Different Species Using H-1 NMR Spectroscopy and Principal Component Analysis . planta medica, 2012, vol. 78, no. 6, p. 641–648. DOI: 10.1055/s-0031-1298240. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CD3OD (chloroform deutere)
Substance:

berberine (RF-00003706-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

HPLC and NMR
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

circa 80
Internal remarks:

Berberine

Composition #13: Fan, Gang., Zhang, Meng Ying., Zhou, Xiang Dong., Lai, Xian Rong., Yue, Qing Hong., Tang, Ce., Luo, Wei Zao., Zhang, Yi. Quality evaluation and species differentiation of Rhizoma coptidis by using proton nuclear magnetic resonance spectroscopy. ANALYTICA CHIMICA ACTA, 2012, vol. 747, p. 76–83. DOI: 10.1016/j.aca.2012.08.038. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

jatrorrhizine (RF-00003887-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

H NMR, HPLC, HPLC-DAD
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Jatrorrhizine

Composition #14: Fan, Gang., Zhang, Meng Ying., Zhou, Xiang Dong., Lai, Xian Rong., Yue, Qing Hong., Tang, Ce., Luo, Wei Zao., Zhang, Yi. Quality evaluation and species differentiation of Rhizoma coptidis by using proton nuclear magnetic resonance spectroscopy. ANALYTICA CHIMICA ACTA, 2012, vol. 747, p. 76–83. DOI: 10.1016/j.aca.2012.08.038. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

Epiberberine (RF-00011173-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

H NMR, HPLC, HPLC-DAD
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

epiberberine

Composition #15: Fan, Gang., Zhang, Meng Ying., Zhou, Xiang Dong., Lai, Xian Rong., Yue, Qing Hong., Tang, Ce., Luo, Wei Zao., Zhang, Yi. Quality evaluation and species differentiation of Rhizoma coptidis by using proton nuclear magnetic resonance spectroscopy. ANALYTICA CHIMICA ACTA, 2012, vol. 747, p. 76–83. DOI: 10.1016/j.aca.2012.08.038. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

columbamine (RF-00011147-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

H NMR, HPLC, HPLC-DAD
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Columbamine