EFSA Compendium of Botanicals

Draft - work in progress

Copaifera langsdorffii Desf.

Family:: Fabaceae
Approval state:: Approved
Number of articles retrieved:: 326
Number of processed references:: 2

Compositions

Endpoint Studies

Genotoxicity

#1: Oleoresin mutagenic #2: kaurenoic acid has DNA damaging activity in cultured Chinese hamster fibroblasts (V79 cells)

Composition #1: Cavalcanti, BC., Costa-lotufo, LV., Moraes, MO., Burbano, RR., Silveira, ER., Cunha, KMA., Rao, VSN., Moura, DJ., Rosa, RM., Henriques, JAP., Pessoa, C. Genotoxicity evaluation of kaurenoic acid, a bioactive diterpenoid present in Copaiba oil. FOOD AND CHEMICAL TOXICOLOGY, 2006, vol. 44, no. 3, p. 388–392. DOI: 10.1016/j.fct.2005.08.011. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Oleo-gum-resin (as part-nature) (A166T)
Substance:

kaurenoic acids (RF-00003462-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

kaurenoic acid

Genotox #1: Chen-Chen, L., Sena, M. A. Toxic and mutagenic activity of oleoresin of Copaiba (Copaifera langsdorfii Desfon) in mice. revista brasileira de plantas medicinais, 2002, p. 37–40. .

Study category:

Mutagenicity
Type of toxicological test:

in vitro mammalian cell micronucleus test (CHD033TT)
Method type:

in vivo
Tested organism:

House mouse (as animal) (A0CNT)
Sex:

No data
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Number of organisms dosed:

7
Control groups used:

yes
Endpoint measured:

gene mutation
Is genotoxic:

Positive
Remarks on genotox study:

the oleoresin of Copaiba exhibited mutagenic activity
Internal remarks:

Oleoresin mutagenic
Internal ID:

CAPLUS_2003:33627

Genotox #2: Cavalcanti, BC., Costa-lotufo, LV., Moraes, MO., Burbano, RR., Silveira, ER., Cunha, KMA., Rao, VSN., Moura, DJ., Rosa, RM., Henriques, JAP., Pessoa, C. Genotoxicity evaluation of kaurenoic acid, a bioactive diterpenoid present in Copaiba oil. FOOD AND CHEMICAL TOXICOLOGY, 2006, vol. 44, no. 3, p. 388–392. DOI: 10.1016/j.fct.2005.08.011. [DOI link]

Study category:

Genotoxicity
Type of toxicological test:

micronucleus assay (CHD051TT)
Method type:

in vitro
Tested organism:

Hamster (as animal) (A0CNX)
Strain of test organism:

lung fibroblasts (V79) (CHD032ST)
Endpoint measured:

DNA damage and/or repair
Is genotoxic:

Positive
Remarks on genotox study:

kaurenoic acid has DNA damaging activity in cultured Chinese hamster fibroblasts (V79 cells), significant toxic range is 30 and 60 μg/ mL
Internal remarks:

kaurenoic acid has DNA damaging activity in cultured Chinese hamster fibroblasts (V79 cells)
Internal ID:

WOS:000236317800010