EFSA Compendium of Botanicals

Draft - work in progress

Convolvulus arvensis L.

Family:: Convolvulaceae
Approval state:: Approved
Number of articles retrieved:: 1381
Number of processed references:: 7

Compositions

#1: Coumarins (isoscopoletin, umbelliferone) #2: tannins #3: anthraquinones #4: coumarins (aerial part) #5: coumarins (live plant) #6: Alkaloids #7: p-coumaric acid #8: Saponins (RF-00004333-PAR) #9: Alkaloids (RF-00004360-PAR) #10: Lectins #11: Calcium oxalate #12: Tropane alkaloids #13: Pyrrolidine alkaloids

Endpoint Studies

#1: livers lesions, acute hepatic necrosis #2: excitable behaviour - depression, hunched posture, dehydration, anorexia, death #3: stomach lesions, retention of plant material in the stomach, acute gastritis, gas distention of the small intestine

Genotoxicity

Composition #1: Khalil, A. M., El-Tawil, B. A. H., Ashy, M. A., Elbeih, F. K. A. Constituents of local plants. Part 8: Distribution of some coumarins in plants of different plant families grown in Saudi Arabia. pharmazie, 1981, p. 569–571. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

isoscopoletin, umbelliferone
Analytical method code:

Chromatographic tests (F015A)
Analytical method - additional description:

TLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Coumarins (isoscopoletin, umbelliferone)

Composition #2: Saleem, Mohammad., Naseer, Faiza., Ahmad, Sohail., Baig, Kashif., Irshad, Iram. In vivo cytotoxic effects of methanol extract of Convolvulus arvensis on 7-12-dimethyl benz(a)antheracene (DMBA) induced skin carcinogenesis. African Journal of Pharmacy and Pharmacology, 2015, p. 397–404. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

tannins

Composition #3: Saleem, Mohammad., Naseer, Faiza., Ahmad, Sohail., Baig, Kashif., Irshad, Iram. In vivo cytotoxic effects of methanol extract of Convolvulus arvensis on 7-12-dimethyl benz(a)antheracene (DMBA) induced skin carcinogenesis. African Journal of Pharmacy and Pharmacology, 2015, p. 397–404. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

anthraquinones (RF-00004343-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

anthraquinones

Composition #4: Manbir, K., Kalia, A.N. Convolvulus arvensis - a useful weed. international journal of pharmacy and pharmaceutical sciences, 2012, vol. 4, no. 1, p. 38–40. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

scopoletin, umbelliferone
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

coumarins (aerial part)

Composition #5: Manbir, K., Kalia, A.N. Convolvulus arvensis - a useful weed. international journal of pharmacy and pharmaceutical sciences, 2012, vol. 4, no. 1, p. 38–40. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

esculetin, scopoletin-7-o-glucoside, beta-methylesculetin
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

coumarins (live plant)

Composition #6: Manbir, K., Kalia, A.N. Convolvulus arvensis - a useful weed. international journal of pharmacy and pharmaceutical sciences, 2012, vol. 4, no. 1, p. 38–40. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

calystegins, cuscohygrine
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids

Composition #7: Manbir, K., Kalia, A.N. Convolvulus arvensis - a useful weed. international journal of pharmacy and pharmaceutical sciences, 2012, vol. 4, no. 1, p. 38–40. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Substance:

p-coumaric acid (RF-00010717-PAR)
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

p-coumaric acid

Composition #8: Said, A.M., Numan, I.T., Hamad, M.N. Study of the cytotoxic and genotoxic effects for fractioniated extracts of Convolulus arvensis on bone marrow in mice. International Journal of Pharmacy and Pharmaceutical Sciences, 2013, vol. 5, no. SUPPL. 2, p. 303–305. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

extracted with 80% aqueous ethanol
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saponins (RF-00004333-PAR)

Composition #9: Said, A.M., Numan, I.T., Hamad, M.N. Study of the cytotoxic and genotoxic effects for fractioniated extracts of Convolulus arvensis on bone marrow in mice. International Journal of Pharmacy and Pharmaceutical Sciences, 2013, vol. 5, no. SUPPL. 2, p. 303–305. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

extracted with 80% aqueous ethanol
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

Pseudotropine, tropine, tropinone, meso-cuscohygrine, Hygrine, calystegine and atropine
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids (RF-00004360-PAR)

Composition #10: Dubois, B., Peumans, WJ., Van Damme, EJM., Van Damme, J., Opdenakker, G. Regulation of gelatinase B (MMP-9) in leukocytes by plant lectins. febs letters, 1998, vol. 427, no. 2, p. 275–278. DOI: 10.1016/S0014-5793(98)00449-9. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

Lectins (RF-00000439-ORG)
Analytical method code:

Electrophoretical tests (F070A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lectins

Composition #11: DOAIGEY, AR. OCCURRENCE, TYPE, AND LOCATION OF CALCIUM-OXALATE CRYSTALS IN LEAVES AND STEMS OF 16 SPECIES OF POISONOUS PLANTS. AMERICAN JOURNAL OF BOTANY, 1991, vol. 78, no. 12, p. 1608–1616. DOI: 10.2307/2444842. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Drying (dehydration) (A07KG)
Additional extraction description:

70% ethanol
Substance:

Calcium oxalate (RF-00003960-PAR)
Analytical method code:

Microscopic detection (F536A)
Analytical method - additional description:

light microscopy
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Calcium oxalate

Composition #12: TODD, FG., STERMITZ, FR., SCHULTHEIS, P., KNIGHT, AP., TRAUBDARGATZ, J. TROPANE ALKALOIDS AND TOXICITY OF CONVOLVULUS-ARVENSIS. PHYTOCHEMISTRY, 1995, vol. 39, no. 2, p. 301–303. DOI: 10.1016/0031-9422(94)00969-Z. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Tropane alkaloids (RF-00000245-TOX)
Additional substance description:

pseudotropine, tropine, tropinone
Analytical method code:

GC-MS/MS (F049A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tropane alkaloids

Composition #13: TODD, FG., STERMITZ, FR., SCHULTHEIS, P., KNIGHT, AP., TRAUBDARGATZ, J. TROPANE ALKALOIDS AND TOXICITY OF CONVOLVULUS-ARVENSIS. PHYTOCHEMISTRY, 1995, vol. 39, no. 2, p. 301–303. DOI: 10.1016/0031-9422(94)00969-Z. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Pyrrolizidine alkaloids (RF-00000230-TOX)
Additional substance description:

hygrine and meso-cuscohygrine
Analytical method code:

GC-MS (F046A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Pyrrolidine alkaloids

Endpoint study #1: TODD, FG., STERMITZ, FR., SCHULTHEIS, P., KNIGHT, AP., TRAUBDARGATZ, J. TROPANE ALKALOIDS AND TOXICITY OF CONVOLVULUS-ARVENSIS. PHYTOCHEMISTRY, 1995, vol. 39, no. 2, p. 301–303. DOI: 10.1016/0031-9422(94)00969-Z. [DOI link]

Study relevance:

Human health
Plant part:

Live plants (as part-nature) (A0BA0)
Preparation/Extraction method:

Fresh (A166Y)
Type of toxicological test:

short-term toxicity (CHD017TT)
Tested organism:

House mouse (as animal) (A0CNT)
Sex:

Male
Route of exposure:

ORAL: FEED (OECD2230PL)
Exposure duration:

6.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

25
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Grams per day (G233A)
Effect concentration:

1.5
Critical effect:

HEPATOTOXICITY (TOX02A)
Target tissue:

digestive: Liver (TT023A)
Effect description:

livers lesions, acute hepatic necrosis
Effect or parameter linked to the endpoint:

histopathology non neoplastic (CHD025BE)
Internal remarks:

livers lesions, acute hepatic necrosis

Endpoint study #2: TODD, FG., STERMITZ, FR., SCHULTHEIS, P., KNIGHT, AP., TRAUBDARGATZ, J. TROPANE ALKALOIDS AND TOXICITY OF CONVOLVULUS-ARVENSIS. PHYTOCHEMISTRY, 1995, vol. 39, no. 2, p. 301–303. DOI: 10.1016/0031-9422(94)00969-Z. [DOI link]

Study relevance:

Human health
Plant part:

Live plants (as part-nature) (A0BA0)
Preparation/Extraction method:

Fresh (A166Y)
Type of toxicological test:

short-term toxicity (CHD017TT)
Tested organism:

House mouse (as animal) (A0CNT)
Sex:

Male
Route of exposure:

ORAL: FEED (OECD2230PL)
Exposure duration:

4.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

25
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Grams per day (G233A)
Effect concentration:

1.5
Critical effect:

NEUROTOXICITY (TOX04A)
Target tissue:

Neurologic (TT004A)
Effect description:

excitable behaviour - depression, hunched posture, dehydration, anorexia, death
Effect or parameter linked to the endpoint:

mortality (CHD010BE)
Internal remarks:

excitable behaviour - depression, hunched posture, dehydration, anorexia, death

Endpoint study #3: TODD, FG., STERMITZ, FR., SCHULTHEIS, P., KNIGHT, AP., TRAUBDARGATZ, J. TROPANE ALKALOIDS AND TOXICITY OF CONVOLVULUS-ARVENSIS. PHYTOCHEMISTRY, 1995, vol. 39, no. 2, p. 301–303. DOI: 10.1016/0031-9422(94)00969-Z. [DOI link]

Study relevance:

Human health
Plant part:

Live plants (as part-nature) (A0BA0)
Preparation/Extraction method:

Fresh (A166Y)
Type of toxicological test:

short-term toxicity (CHD017TT)
Tested organism:

House mouse (as animal) (A0CNT)
Sex:

Male
Route of exposure:

ORAL: FEED (OECD2230PL)
Exposure duration:

4.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

25
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Grams per day (G233A)
Effect concentration:

1.5
Critical effect:

Digestive (TOX18A)
Target tissue:

digestive: Stomach (TT027A)
Effect description:

stomach lesions, acute gastritis, gas distention of the small intestine, retention of plant material in the stomach
Effect or parameter linked to the endpoint:

histopathology non neoplastic (CHD025BE)
Internal remarks:

stomach lesions, retention of plant material in the stomach, acute gastritis, gas distention of the small intestine