Draft - work in progress
      
      
        
          
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        -  Conioselinum vaginatum (Spreng.) Thell. // Conioselinum univittatum Turcz. ex Kar. & Kir.
 
          
        
      
      
      
      
      
  
Conioselinum vaginatum (Spreng.) Thell. // Conioselinum univittatum Turcz. ex Kar. & Kir.
  - Family:
 - Apiaceae
 
  - Approval state:
 - Approved
 
  - Number of articles retrieved:
 - 8
 
  - Number of processed references:
 - 2
 
    Composition #1: Tsao, Daniel., Lynn, E. V. Chemical study of two Chinese drugs. Journal of the American Pharmaceutical Association, None, p. 720–722. .
        
    
  
    
  
  
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                Plant part:
            
            
                Roots and other underground parts (as part-nature) (A067M)
            
         
     
   
  
  
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                Extraction/Preparation method:
            
            
                Solvent extraction (A0BZR)
            
         
     
   
  
  
  
  
  
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                Substance:
            
            
                Tannins (RF-00004337-PAR)
            
         
     
   
  
  
  
  
  
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                Analytical method code:
            
            
                Traditional analytical techniques (wet chemical tests) (F003A)
            
         
     
   
  
  
  
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                Result unit:
            
            
                Percent/sample (G087A)
            
         
     
   
  
  
  
  
  
  
  
  
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                Result expression:
            
            
                Whole weight (B001A)
            
         
     
   
  
  
  
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                Result type:
            
            
                Numerical Value (VAL)
            
         
     
   
  
  
  
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                Value (concentration, content):
            
            
                0.34 -0.42
            
         
     
   
  
  
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                Internal remarks:
            
            
                tannins
            
         
     
   
  
  
  
  
 
    Composition #2: Pansatiankul, B J., Mekmanee, R. Dicumarol content in alcoholic herb elixirs: one of the factors at risk induced IVKD-I.. The Southeast Asian journal of tropical medicine and public health, 1993, vol. 24 Suppl 1, p. 201–3. .
        
    
  
    
  
  
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                Plant part:
            
            
                Unspecified (A07XD)
            
         
     
   
  
  
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                Extraction/Preparation method:
            
            
                Solvent extraction (A0BZR)
            
         
     
   
  
  
  
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                Additional extraction description:
            
            
                ethanol
            
         
     
   
  
  
  
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                Substance:
            
            
                dicumarol (RF-00003773-PAR)
            
         
     
   
  
  
  
  
  
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                Analytical method code:
            
            
                High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
            
         
     
   
  
  
  
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                Result unit:
            
            
                Microgram/litre (G051A)
            
         
     
   
  
  
  
  
  
  
  
  
  
  
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                Result type:
            
            
                Numerical Value (VAL)
            
         
     
   
  
  
  
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                Value (concentration, content):
            
            
                400
            
         
     
   
  
  
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                Internal remarks:
            
            
                dicumarol
            
         
     
   
  
  
  
  
 
  Endpoint study
      #1: Pansatiankul, B J., Mekmanee, R. Dicumarol content in alcoholic herb elixirs: one of the factors at risk induced IVKD-I.. The Southeast Asian journal of tropical medicine and public health, 1993, vol. 24 Suppl 1, p. 201–3. .
        
  
  
    
  
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                Study relevance:
            
            
                Human health
            
         
     
   
  
  
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                Substance:
            
            
                dicumarol (RF-00003773-PAR)
            
         
     
   
  
  
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                Plant part:
            
            
                Unspecified (A07XD)
            
         
     
   
  
  
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                Preparation/Extraction method:
            
            
                Solvent extraction (A0BZR)
            
         
     
   
  
  
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                Additional plant/substance description:
            
            
                ethanol extraction of dicumarol
            
         
     
   
  
  
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                Type of toxicological test:
            
            
                short-term toxicity (CHD017TT)
            
         
     
   
  
  
  
  
  
  
  
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                Tested organism:
            
            
                Human (as organism) (A056J)
            
         
     
   
  
  
  
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                Route of exposure:
            
            
                OTHER (OECD0PL)
            
         
     
   
  
  
  
  
  
  
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                Endpoint measured:
            
            
                Dose not reported (CHD066EP)
            
         
     
   
  
  
  
  
  
  
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                Critical effect:
            
            
                HEMOPOIETIC (TOX10A)
            
         
     
   
  
  
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                Target tissue:
            
            
                cardiovascular / haematological: Blood Coagulation (TT010A)
            
         
     
   
  
  
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                Effect description:
            
            
                inducing bleeding diathesis in breast-fed infants of mothers known to consume the elixir
            
         
     
   
  
  
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                Effect or parameter linked to the endpoint:
            
            
                haematology (CHD023BE)
            
         
     
   
  
  
  
  
  
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                Internal remarks:
            
            
                inducing bleeding diathesis in breast-fed infants of mothers known to consume the elixir