EFSA Compendium of Botanicals

Endpoint study #1: Tzeng, H.-P., Chiang, W., Ueng, T.-H., Liu, S.-H. The abortifacient effects from the seeds of Coix lachryma-jobi L. var. ma-yuen Stapf. Journal of Toxicology and Environmental Health - Part A, 2005, vol. 68, no. 17-18, p. 1557–1565. DOI: 10.1080/15287390590967504. [DOI link]

Study relevance:

Human health
Plant part:

Seed (as part-nature) (A066P)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

water
Type of toxicological test:

reproduction toxicity (CHD009TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Wistar (CHD013ST)
Sex:

Female
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Exposure duration:

10.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

10
Control groups used:

yes
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Gram/kilogram (G015A)
Effect concentration:

1
Critical effect:

REPRODUCTIVE (TOX05A)
Target tissue:

urogenital: Uterus (TT052A)
Effect description:

significant increase in the incidence of fetal resorptions.
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

The water extracts of adlay seeds are capable of inducing embryotoxicity and enhancing uterine contractility during pregnancy

Job's tears (as plant) // Coix lacryma-jobi L.