EFSA Compendium of Botanicals

Draft - work in progress

Coconut (as plant) // Cocos nucifera L.

Family:: Arecaceae
Approval state:: Approved
Number of articles retrieved:: 5218
Number of processed references:: 2

Compositions

Endpoint Studies

Genotoxicity

#1: Mutagenic activity caused by plant chloroform extract

Composition #1: Silva, L. C. R., Nunes-Pinheiro, D. C. S., Morais, S. M., Lopes-Neto, B. E., Santos, G. J. L., Campello, C. C. Toxicological evaluation and effect of ethyl acetate extract of the fiber of Cocos nucifera L. (Palmae) on inflammatory response in vivo . revista brasileira de plantas medicinais, 2009, vol. 11, no. 4, p. 429–434. DOI: 10.1590/S1516-05722009000400011. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethylacetate
Substance:

Proanthocyanidins (condensed tannins) Proanthocyanidins (condensed tannins) (RF-00004370-PAR)
Additional substance description:

extracted from green Coconut peel fibers
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Condensed tannins

Genotox #1: Abudayyak, Mahmoud., Ozdemir Nath, Ebru., Ozhan, Gul. Toxic potentials of ten herbs commonly used for aphrodisiac effect in Turkey . turkish journal of medical sciences, 2015, vol. 45, no. 3, p. 496–506. DOI: 10.3906/sag-1401-153. [DOI link]

Study category:

Mutagenicity
Type of toxicological test:

bacterial reverse mutation assay (CHD028TT)
Method type:

in vitro
Tested organism:

Salmonella typhimurium (as organism) (A0CPZ)
Strain of test organism:

TA 98 (CHD029ST)
Exogenous metabolic activation applied:

with
Is genotoxic:

Positive
Remarks on genotox study:

chloroform extract: mutagenic activity with TA98 (dose tested 0.78-25 mg/mL) but negative with TA100
Internal remarks:

Mutagenic activity caused by plant chloroform extract
Internal ID:

WOS:000356357800005