EFSA Compendium of Botanicals

Draft - work in progress

Cnidium monnieri (L.) Cusson

Family:: Apiaceae
Approval state:: Approved
Number of articles retrieved:: 514
Number of processed references:: 4

Compositions

#1: Myrcene #2: Dihydrocarvone #3: Imperatorin #4: Xanthotoxin #5: Osthole #6: Bergapten #7: Isopimpinellin #8: Bergapten #9: Imperatorin #10: O-Acetylcolumbianetin #11: Oroselone #12: Osthole #13: Coumarins #14: Xanthotoxol

Endpoint Studies

Genotoxicity

Composition #1: Meng, Zhengmu., Jin, Changgen., Zhao, Shouxun., Ji, Jiang. GC-MS analysis of essential oil from Cnidium monnieri. nanjing yaoxueyuan xuebao, 1986, p. 167–174. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Myrcene

Composition #2: Meng, Zhengmu., Jin, Changgen., Zhao, Shouxun., Ji, Jiang. GC-MS analysis of essential oil from Cnidium monnieri. nanjing yaoxueyuan xuebao, 1986, p. 167–174. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Dihydrocarvone (RF-00011286-PAR)
Analytical method code:

GC-MS (F046A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Dihydrocarvone

Composition #3: Liu, RM., Feng, L., Sun, AL., Kong, LY. Preparative isolation and purification of coumarins from Cnidium monnieri (L.) Cusson by high-speed counter-current chromatography. JOURNAL OF CHROMATOGRAPHY A, 2004, vol. 1055, no. 1-2, p. 71–76. DOI: 10.1016/j.chroma.2004.09.017. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

imperatorin (RF-00003874-PAR)
Analytical method code:

Chromatographic tests (F015A)
Analytical method - additional description:

HSCC, HPLC, H NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Imperatorin

Composition #4: Liu, RM., Feng, L., Sun, AL., Kong, LY. Preparative isolation and purification of coumarins from Cnidium monnieri (L.) Cusson by high-speed counter-current chromatography. JOURNAL OF CHROMATOGRAPHY A, 2004, vol. 1055, no. 1-2, p. 71–76. DOI: 10.1016/j.chroma.2004.09.017. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

Methoxsalen Methoxsalen (RF-00003863-PAR)
Additional substance description:

Xanthotoxin
Analytical method code:

Chromatographic tests (F015A)
Analytical method - additional description:

HSCC, HPLC, H NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Xanthotoxin

Composition #5: Liu, RM., Feng, L., Sun, AL., Kong, LY. Preparative isolation and purification of coumarins from Cnidium monnieri (L.) Cusson by high-speed counter-current chromatography. JOURNAL OF CHROMATOGRAPHY A, 2004, vol. 1055, no. 1-2, p. 71–76. DOI: 10.1016/j.chroma.2004.09.017. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

osthol (RF-00011008-PAR)
Additional substance description:

Osthole
Analytical method code:

Chromatographic tests (F015A)
Analytical method - additional description:

HSCC, HPLC, H NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Osthole

Composition #6: Liu, RM., Feng, L., Sun, AL., Kong, LY. Preparative isolation and purification of coumarins from Cnidium monnieri (L.) Cusson by high-speed counter-current chromatography. JOURNAL OF CHROMATOGRAPHY A, 2004, vol. 1055, no. 1-2, p. 71–76. DOI: 10.1016/j.chroma.2004.09.017. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

Bergapten (RF-00003837-PAR)
Analytical method code:

Chromatographic tests (F015A)
Analytical method - additional description:

HSCC, HPLC, H NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Bergapten

Composition #7: Liu, RM., Feng, L., Sun, AL., Kong, LY. Preparative isolation and purification of coumarins from Cnidium monnieri (L.) Cusson by high-speed counter-current chromatography. JOURNAL OF CHROMATOGRAPHY A, 2004, vol. 1055, no. 1-2, p. 71–76. DOI: 10.1016/j.chroma.2004.09.017. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

Isopimpinellin (RF-00003784-PAR)
Analytical method code:

Chromatographic tests (F015A)
Analytical method - additional description:

HSCC, HPLC, H NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isopimpinellin

Composition #8: Chen, Danxia., Wang, Jiajing., Jiang, Yunyun., Zhou, Tingting., Fan, Guorong., Wu, Yutian. Separation and determination of coumarins in Fructus cnidii extracts by pressurized capillary electrochromatography using a packed column with a monolithic outlet frit . journal of pharmaceutical and biomedical analysis, 2009, vol. 50, no. 5, p. 695–702. DOI: 10.1016/j.jpba.2009.05.026. [DOI link]

Language:

English (en)
Plant part:

Fruit peel (as part-nature) (A067G)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 95% + ultrasonic extraction
Substance:

Bergapten (RF-00003837-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

<=3.41
Internal remarks:

Bergapten

Composition #9: Chen, Danxia., Wang, Jiajing., Jiang, Yunyun., Zhou, Tingting., Fan, Guorong., Wu, Yutian. Separation and determination of coumarins in Fructus cnidii extracts by pressurized capillary electrochromatography using a packed column with a monolithic outlet frit . journal of pharmaceutical and biomedical analysis, 2009, vol. 50, no. 5, p. 695–702. DOI: 10.1016/j.jpba.2009.05.026. [DOI link]

Language:

English (en)
Plant part:

Fruit peel (as part-nature) (A067G)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 95% + ultrasonic extraction
Substance:

imperatorin (RF-00003874-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

<=7.25
Internal remarks:

Imperatorin

Composition #10: Chen, Danxia., Wang, Jiajing., Jiang, Yunyun., Zhou, Tingting., Fan, Guorong., Wu, Yutian. Separation and determination of coumarins in Fructus cnidii extracts by pressurized capillary electrochromatography using a packed column with a monolithic outlet frit . journal of pharmaceutical and biomedical analysis, 2009, vol. 50, no. 5, p. 695–702. DOI: 10.1016/j.jpba.2009.05.026. [DOI link]

Language:

English (en)
Plant part:

Fruit peel (as part-nature) (A067G)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 95% + ultrasonic extraction
Substance:

Columbianetin Acetate (RF-00011108-PAR)
Additional substance description:

O-Acetylcolumbianetin
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

<=7.86
Internal remarks:

O-Acetylcolumbianetin

Composition #11: Chen, Danxia., Wang, Jiajing., Jiang, Yunyun., Zhou, Tingting., Fan, Guorong., Wu, Yutian. Separation and determination of coumarins in Fructus cnidii extracts by pressurized capillary electrochromatography using a packed column with a monolithic outlet frit . journal of pharmaceutical and biomedical analysis, 2009, vol. 50, no. 5, p. 695–702. DOI: 10.1016/j.jpba.2009.05.026. [DOI link]

Language:

English (en)
Plant part:

Fruit peel (as part-nature) (A067G)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 95% + ultrasonic extraction
Substance:

Oroselone (RF-00011113-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

<=8.26
Internal remarks:

Oroselone

Composition #12: Chen, Danxia., Wang, Jiajing., Jiang, Yunyun., Zhou, Tingting., Fan, Guorong., Wu, Yutian. Separation and determination of coumarins in Fructus cnidii extracts by pressurized capillary electrochromatography using a packed column with a monolithic outlet frit . journal of pharmaceutical and biomedical analysis, 2009, vol. 50, no. 5, p. 695–702. DOI: 10.1016/j.jpba.2009.05.026. [DOI link]

Language:

English (en)
Plant part:

Fruit peel (as part-nature) (A067G)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 95% + ultrasonic extraction
Substance:

osthol (RF-00011008-PAR)
Additional substance description:

Osthole
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

<=16.41
Internal remarks:

Osthole

Composition #13: Shin, Eunjin., Lee, Chul., Sung, Sang Hyun., Kim, Young Choong., Hwang, Bang Yeon., Lee, Mi Kyeong. Antifibrotic activity of coumarins from Cnidium monnieri fruits in HSC-T6 hepatic stellate cells. JOURNAL OF NATURAL MEDICINES, 2011, vol. 65, no. 2, p. 370–374. DOI: 10.1007/s11418-010-0485-7. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

auraptenol, meranzin, meranzin hydrate, 7-hydroxy-8-methoxy coumarin
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

silica gel column chromatography
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Coumarins

Composition #14: Shin, Eunjin., Lee, Chul., Sung, Sang Hyun., Kim, Young Choong., Hwang, Bang Yeon., Lee, Mi Kyeong. Antifibrotic activity of coumarins from Cnidium monnieri fruits in HSC-T6 hepatic stellate cells. JOURNAL OF NATURAL MEDICINES, 2011, vol. 65, no. 2, p. 370–374. DOI: 10.1007/s11418-010-0485-7. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Xanthotoxol (RF-00011114-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

silica gel column chromatography
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Xanthotoxol