EFSA Compendium of Botanicals

Draft - work in progress

Cnestis polyphylla Lam // Cnestis glabra Lam.

Family:: Connaraceae
Approval state:: Approved
Number of articles retrieved:: 11
Number of processed references:: 2

Compositions

Endpoint Studies

#1: convulsions in several mammalian species

Genotoxicity

Composition #1: JEANNODA, VLR., CREPPY, EE., DIRHEIMER, G. ISOLATION AND PARTIAL CHARACTERIZATION OF GLABRIN, A NEUROTOXIN FROM CNESTIS-GLABRA (CONNARACEAE) ROOT BARKS. BIOCHIMIE, 1984, vol. 66, no. 7-8, p. 557–562. DOI: 10.1016/0300-9084(84)90150-0. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Drying (dehydration) (A07KG)
Additional extraction description:

Powder suspended in water, then refluxed
Substance:

glabrin (RF-00011026-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

ion-exchange chromatography
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.4
Internal remarks:

Glabrin

Composition #2: JEANNODA, VLR., RAKOTORANOROMALALA, DAD., VALISOLALAO, J., CREPPY, EE., DIRHEIMER, G. NATURAL OCCURRENCE OF METHIONINE SULFOXIMINE IN THE CONNARACEAE FAMILY. JOURNAL OF ETHNOPHARMACOLOGY, 1985, vol. 14, no. 1, p. 11–17. DOI: 10.1016/0378-8741(85)90023-6. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Drying (dehydration) (A07KG)
Additional extraction description:

crude extract treated with 30% ethanol
Substance:

methionine sulfoximine (RF-00010850-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

ion-exchange chromatography
Result unit:

Gram/kilogram (G015A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.47 - 3.9
Internal remarks:

Methionine sulfoximine

Endpoint study #1: JEANNODA, VLR., RAKOTORANOROMALALA, DAD., VALISOLALAO, J., CREPPY, EE., DIRHEIMER, G. NATURAL OCCURRENCE OF METHIONINE SULFOXIMINE IN THE CONNARACEAE FAMILY. JOURNAL OF ETHNOPHARMACOLOGY, 1985, vol. 14, no. 1, p. 11–17. DOI: 10.1016/0378-8741(85)90023-6. [DOI link]

Study relevance:

Human health
Substance:

methionine sulfoximine (RF-00010850-PAR)
Type of toxicological test:

not reported (CHD015TT)
Sex:

No data
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Control groups used:

no data
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

NEUROTOXICITY (TOX04A)
Target tissue:

Neurologic (TT004A)
Effect description:

convulsions in several mammalian species
Effect or parameter linked to the endpoint:

neurology (CHD027BE)
Internal remarks:

convulsions in several mammalian species