EFSA Compendium of Botanicals

Draft - work in progress

Blue pea (as plant) // Clitoria ternatea L.

Family:: Fabaceae
Approval state:: Approved
Number of articles retrieved:: 724
Number of processed references:: 3

Compositions

#1: Alkaloids #2: Saponins #3: Coumarin #4: Anthraquinones #5: Saponins #6: Alkaloids #7: Tannins

Endpoint Studies

Genotoxicity

Composition #1: Sinha, S. K. P., Dogra, J. V. V. A survey of the plants of Bhagalpur and Santhal Pargana for saponin, flavonoids and alkaloids. International Journal of Crude Drug Research, 1985, p. 77–86. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids

Composition #2: Sinha, S. K. P., Dogra, J. V. V. A survey of the plants of Bhagalpur and Santhal Pargana for saponin, flavonoids and alkaloids. International Journal of Crude Drug Research, 1985, p. 77–86. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saponins

Composition #3: Deshmukh, S., Rathod, V.J. Ethnopharmacognostical screening of Clitoria ternatea Linn. International Journal of PharmTech Research, 2014, vol. 6, no. 2, p. 769–774. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

petroleum ether
Substance:

Coumarin (RF-00000370-TOX)
Analytical method code:

Phytochemical screening (F604A)
Analytical method - additional description:

chemical reagents
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Coumarin

Composition #4: Deshmukh, S., Rathod, V.J. Ethnopharmacognostical screening of Clitoria ternatea Linn. International Journal of PharmTech Research, 2014, vol. 6, no. 2, p. 769–774. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water, soxhelt extraction
Substance:

anthraquinones (RF-00004343-PAR)
Analytical method code:

Phytochemical screening (F604A)
Analytical method - additional description:

chemical reagents
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Anthraquinones

Composition #5: Deshmukh, S., Rathod, V.J. Ethnopharmacognostical screening of Clitoria ternatea Linn. International Journal of PharmTech Research, 2014, vol. 6, no. 2, p. 769–774. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acetone, EtOH, H2O
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Analytical method - additional description:

chemical reagents
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saponins

Composition #6: Deshmukh, S., Rathod, V.J. Ethnopharmacognostical screening of Clitoria ternatea Linn. International Journal of PharmTech Research, 2014, vol. 6, no. 2, p. 769–774. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH, soxhelt extraction
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Analytical method - additional description:

chemical reagents
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids

Composition #7: Deshmukh, S., Rathod, V.J. Ethnopharmacognostical screening of Clitoria ternatea Linn. International Journal of PharmTech Research, 2014, vol. 6, no. 2, p. 769–774. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol, acetone, H2O
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Analytical method - additional description:

chemical reagents
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins

Endpoint study #1: Karta, Jessica., Pandjaitan, Maruli., Rahminiwati, Min. EVALUATION OF ACUTE ORAL TOXICITY OF BUTTERFLY PEA ROOT EXTRACT ON EXPERIMENTAL MICE. (ICICI-BME), 2013, p. 317–323. .

Study relevance:

Human health
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

unspecified
Type of toxicological test:

short-term toxicity (CHD017TT)
Tested organism:

House mouse (as animal) (A0CNT)
Sex:

Male
Exposure duration:

14.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

20
Control groups used:

yes
Endpoint measured:

Concentration producing lethality in 50% of experimental organisms (CHD023EP)
Concentration unit:

Gram/kilogram (G015A)
Effect concentration:

32
Critical effect:

HEPATOTOXICITY (TOX02A)
Target tissue:

digestive: Liver (TT023A)
Effect description:

Histopathology results show the acute exposure of Butterfly Pea Roots extract led to relatively severe damage on liver
Effect or parameter linked to the endpoint:

mortality (CHD010BE)
Internal remarks:

Liver toxicity

Endpoint study #2: Karta, Jessica., Pandjaitan, Maruli., Rahminiwati, Min. EVALUATION OF ACUTE ORAL TOXICITY OF BUTTERFLY PEA ROOT EXTRACT ON EXPERIMENTAL MICE. (ICICI-BME), 2013, p. 317–323. .

Study relevance:

Human health
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

unspecified
Type of toxicological test:

short-term toxicity (CHD017TT)
Tested organism:

House mouse (as animal) (A0CNT)
Sex:

Male
Exposure duration:

14.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

20
Control groups used:

yes
Endpoint measured:

Concentration producing lethality in 50% of experimental organisms (CHD023EP)
Concentration unit:

Gram/kilogram (G015A)
Effect concentration:

32
Critical effect:

NEPHROTOXICITY (TOX03A)
Target tissue:

urogenital: Kidneys (TT046A)
Effect description:

Histopathology results show the acute exposure of Butterfly Pea Roots extract led to relatively severe damage on kidneys
Effect or parameter linked to the endpoint:

mortality (CHD010BE)
Internal remarks:

Nephrotoxicity