Draft - work in progress
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- Clerodendrum phlomidis L.f.
Clerodendrum phlomidis L.f.
- Family:
- Lamiaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 85
- Number of processed references:
- 3
Composition #1: Kumar, D., Kumar, A., Prakash, O. Post-coital antifertility activity of clerodendrum phlomidis Linn. Dichloromethane root extract. pharmacologyonline, 2010, vol. 3, p. 479–485. .
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
dichloromethane
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Substance:
cardiac glycosides (RF-00010823-PAR)
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Analytical method code:
Phytochemical screening (F604A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Cardiac glycosides
Composition #2: Florence, A.R., Joselin, J., Jeeva, S. Intra-specific variation of bioactive principles in select members of the genus Clerodendrum L. journal of chemical and pharmaceutical research, 2012, vol. 4, no. 11, p. 4908–4914. .
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
water
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Substance:
Alkaloids (RF-00004360-PAR)
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Analytical method code:
Phytochemical screening (F604A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Alkaloids
Composition #3: Florence, A.R., Joselin, J., Jeeva, S. Intra-specific variation of bioactive principles in select members of the genus Clerodendrum L. journal of chemical and pharmaceutical research, 2012, vol. 4, no. 11, p. 4908–4914. .
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
water
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Substance:
Saponins (RF-00004333-PAR)
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Analytical method code:
Phytochemical screening (F604A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Saponins
Composition #4: Bharitkar, Yogesh P., Hazra, Abhijit., Shah, Siddharth., Saha, Sudeshna., Matoori, Anil Kumar., Mondal, Nirup B. New flavonoid glycosides and other chemical constituents from Clerodendrum phlomidis leaves: isolation and characterisation.. Natural product research, 2015, vol. 29, no. 19, p. 1850–6. DOI: 10.1080/14786419.2015.1009457.
[
DOI link]
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
methanol
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Substance:
andrographolide (RF-00004145-PAR)
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Analytical method code:
Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
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Analytical method - additional description:
NMR and IR
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
andrographolide
Endpoint study
#1: Kumar, D., Kumar, A., Prakash, O. Post-coital antifertility activity of clerodendrum phlomidis Linn. Dichloromethane root extract. pharmacologyonline, 2010, vol. 3, p. 479–485. .
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Study relevance:
Human health
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
dichloromethane extract
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Type of toxicological test:
reproduction toxicity (CHD009TT)
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Tested organism:
Rat (as animal) (A0CNV)
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Route of exposure:
ORAL: FEED (OECD2230PL)
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Unit of exposure duration:
Day (G134A)
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Endpoint measured:
Dose level (CHD014EP)
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Concentration unit:
Milligram/kilogram (G061A)
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Effect concentration:
>200
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Critical effect:
REPRODUCTIVE (TOX05A)
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Target tissue:
urogenital: Uterus (TT052A)
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Effect description:
antiimplantation activity
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Effect or parameter linked to the endpoint:
reproduction (CHD014BE)
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Internal remarks:
Antiimplantation activity
