EFSA Compendium of Botanicals

Draft - work in progress

Citrus junos Siebold ex Tanaka

Family:: Rutaceae
Approval state:: Approved
Number of articles retrieved:: 636
Number of processed references:: 5

Compositions

#1: l-synephrine #2: limonin #3: deacetylnomilin #4: auraptene #5: 9-hydroxy-4-methoxypsoralen #6: Sissotrin #7: Prunetin #8: Genistein #9: Daidzin #10: Genistin #11: Formononetin #12: Biochanin A #13: Daidzein #14: Myrcene #15: Nomilin

Endpoint Studies

Genotoxicity

Composition #1: Kusu, Fumiyo., Matsumoto, Katsumi., Takamura, Kiyoko. Direct separation and determination of synephrine enantiomers by high-performance liquid chromatography with electrochemical detection. Chemical Pharmaceutical Bulletin, 1995, p. 1158–1161. .

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Water
Substance:

synephrine (RF-00004068-PAR)
Additional substance description:

l-synephrine
Analytical method code:

HPLC-UV (F021A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.067
Internal remarks:

l-synephrine

Composition #2: Eun Jung Cho., Piao, X., Piao, L., Piao, H., Man Ki Park., Bak Kwang Kim., Jeong Hill Park. Chemical constituents of the fruit of Citrus junos. Natural Product Sciences, 2000, vol. 6, no. 4, p. 179–182. .

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

limonin (RF-00011197-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

limonin

Composition #3: Eun Jung Cho., Piao, X., Piao, L., Piao, H., Man Ki Park., Bak Kwang Kim., Jeong Hill Park. Chemical constituents of the fruit of Citrus junos. Natural Product Sciences, 2000, vol. 6, no. 4, p. 179–182. .

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

deacetylnomilin (RF-00011195-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

deacetylnomilin

Composition #4: Eun Jung Cho., Piao, X., Piao, L., Piao, H., Man Ki Park., Bak Kwang Kim., Jeong Hill Park. Chemical constituents of the fruit of Citrus junos. Natural Product Sciences, 2000, vol. 6, no. 4, p. 179–182. .

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

auraptene (RF-00010983-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

auraptene

Composition #5: Eun Jung Cho., Piao, X., Piao, L., Piao, H., Man Ki Park., Bak Kwang Kim., Jeong Hill Park. Chemical constituents of the fruit of Citrus junos. Natural Product Sciences, 2000, vol. 6, no. 4, p. 179–182. .

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

Furanocoumarins (RF-00004381-PAR)
Additional substance description:

8-Hydroxybergapten
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

9-hydroxy-4-methoxypsoralen

Composition #6: Koblovska, Radka., Mackova, Zuzana., Vitkova, Michaela., Kokoska, Ladislav., Klejdus, Borivoj., Lapcik, Oldrich. Isoflavones in the Rutaceae family: Twenty selected representatives of the genera Citrus, Fortunella, Poncirus, Ruta and Severinia. PHYTOCHEMICAL ANALYSIS, 2008, vol. 19, no. 1, p. 64–70. DOI: 10.1002/pca.1016. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

80% ethanol
Substance:

Sissotrin (RF-00011021-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

HPLC-ELISA
Result unit:

Nanogram/gram (G076A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

67.8
Internal remarks:

Sissotrin

Composition #7: Koblovska, Radka., Mackova, Zuzana., Vitkova, Michaela., Kokoska, Ladislav., Klejdus, Borivoj., Lapcik, Oldrich. Isoflavones in the Rutaceae family: Twenty selected representatives of the genera Citrus, Fortunella, Poncirus, Ruta and Severinia. PHYTOCHEMICAL ANALYSIS, 2008, vol. 19, no. 1, p. 64–70. DOI: 10.1002/pca.1016. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

80% ethanol
Substance:

Prunetin (RF-00011016-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

HPLC-ELISA
Result unit:

Nanogram/gram (G076A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

82.7
Internal remarks:

Prunetin

Composition #8: Koblovska, Radka., Mackova, Zuzana., Vitkova, Michaela., Kokoska, Ladislav., Klejdus, Borivoj., Lapcik, Oldrich. Isoflavones in the Rutaceae family: Twenty selected representatives of the genera Citrus, Fortunella, Poncirus, Ruta and Severinia. PHYTOCHEMICAL ANALYSIS, 2008, vol. 19, no. 1, p. 64–70. DOI: 10.1002/pca.1016. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

80% ethanol
Substance:

genistein (RF-00000297-NTR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

HPLC-ELISA
Result unit:

Nanogram/gram (G076A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

6.4
Internal remarks:

Genistein

Composition #9: Koblovska, Radka., Mackova, Zuzana., Vitkova, Michaela., Kokoska, Ladislav., Klejdus, Borivoj., Lapcik, Oldrich. Isoflavones in the Rutaceae family: Twenty selected representatives of the genera Citrus, Fortunella, Poncirus, Ruta and Severinia. PHYTOCHEMICAL ANALYSIS, 2008, vol. 19, no. 1, p. 64–70. DOI: 10.1002/pca.1016. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

80% ethanol
Substance:

daidzin (RF-00003763-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

HPLC-ELISA
Result unit:

Nanogram/gram (G076A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.3
Internal remarks:

Daidzin

Composition #10: Koblovska, Radka., Mackova, Zuzana., Vitkova, Michaela., Kokoska, Ladislav., Klejdus, Borivoj., Lapcik, Oldrich. Isoflavones in the Rutaceae family: Twenty selected representatives of the genera Citrus, Fortunella, Poncirus, Ruta and Severinia. PHYTOCHEMICAL ANALYSIS, 2008, vol. 19, no. 1, p. 64–70. DOI: 10.1002/pca.1016. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

80% ethanol
Substance:

genistin (RF-00003829-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

HPLC-ELISA
Result unit:

Nanogram/gram (G076A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

58.1
Internal remarks:

Genistin

Composition #11: Koblovska, Radka., Mackova, Zuzana., Vitkova, Michaela., Kokoska, Ladislav., Klejdus, Borivoj., Lapcik, Oldrich. Isoflavones in the Rutaceae family: Twenty selected representatives of the genera Citrus, Fortunella, Poncirus, Ruta and Severinia. PHYTOCHEMICAL ANALYSIS, 2008, vol. 19, no. 1, p. 64–70. DOI: 10.1002/pca.1016. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

80% ethanol
Substance:

formononetin (RF-00000291-NTR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

HPLC-ELISA
Result unit:

Nanogram/gram (G076A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

680
Internal remarks:

Formononetin

Composition #12: Koblovska, Radka., Mackova, Zuzana., Vitkova, Michaela., Kokoska, Ladislav., Klejdus, Borivoj., Lapcik, Oldrich. Isoflavones in the Rutaceae family: Twenty selected representatives of the genera Citrus, Fortunella, Poncirus, Ruta and Severinia. PHYTOCHEMICAL ANALYSIS, 2008, vol. 19, no. 1, p. 64–70. DOI: 10.1002/pca.1016. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

80% ethanol
Substance:

biochanin-A (RF-00004182-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

HPLC-ELISA
Result unit:

Nanogram/gram (G076A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

79.8
Internal remarks:

Biochanin A

Composition #13: Koblovska, Radka., Mackova, Zuzana., Vitkova, Michaela., Kokoska, Ladislav., Klejdus, Borivoj., Lapcik, Oldrich. Isoflavones in the Rutaceae family: Twenty selected representatives of the genera Citrus, Fortunella, Poncirus, Ruta and Severinia. PHYTOCHEMICAL ANALYSIS, 2008, vol. 19, no. 1, p. 64–70. DOI: 10.1002/pca.1016. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

80% ethanol
Substance:

daidzein (RF-00000061-NTR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

HPLC-ELISA
Result unit:

Nanogram/gram (G076A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

14.2
Internal remarks:

Daidzein

Composition #14: Lan-Phi, Nguyen Thi., Shimamura, Tornoko., Ukeda, Hiroyuki., Sawamura, Masayoshi. Chemical and aroma profiles of yuzu (Citrus junos) peel oils of different cultivars . food chemistry, 2009, vol. 115, no. 3, p. 1042–1047. DOI: 10.1016/j.foodchem.2008.12.024. [DOI link]

Language:

English (en)
Plant part:

Fruit peel (as part-nature) (A067G)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

cold pressed
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3- 3.2
Internal remarks:

Myrcene

Composition #15: HASHINAGA, F. METABOLISM OF C-14 NOMILIN IN YUZU FRUIT. journal of the japanese society for food science and technology-nippon shokuhin kagaku kogaku kaishi, 1991, vol. 38, no. 7, p. 629–632. .

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethyl acetate
Substance:

Nomilin (RF-00011194-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Nomilin