EFSA Compendium of Botanicals

Draft - work in progress

Cistus monspeliensis L.

Family:: Cistaceae
Approval state:: Approved
Number of articles retrieved:: 247
Number of processed references:: 4

Compositions

#1: Labdanes (Manoyl oxide and derivatives) - fruit hexane extract #2: Labdanes (Manoyl oxide and derivatives) - leaves essential oil #3: Clerodanes (cistodiol) - fruit essential oil #4: Labdanes (Manoyl oxide and derivatives) - leaves hexane extract #5: Labdanes (Manoyl oxide and derivatives) - fruit essential oil #6: Clerodanes (cistodiol) - fruit hexane extract #7: Clerodanes (cistodiol) - leaves hexane extract #8: labdane diterpenes #9: clerodane diterpenes #10: Gallic acid #11: 1,8-cineole #12: camphor #13: eugenol

Endpoint Studies

Genotoxicity

Composition #1: Angelopoulou, D., Demetzos, C., Dimas, C., Perdetzoglou, D., Loukis, A. Essential oils and hexane extracts from leaves and fruits of Cistus monspeliensis. Cytotoxic activity of ent-13-epi-manoyl oxide and its isomers . planta medica, 2001, vol. 67, no. 2, p. 168–171. DOI: 10.1055/s-2001-11497. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane
Substance:

labdane diterpenes (RF-00004392-PAR)
Additional substance description:

manoyl oxide and derivatives
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

25
Internal remarks:

Labdanes (Manoyl oxide and derivatives) - fruit hexane extract

Composition #2: Angelopoulou, D., Demetzos, C., Dimas, C., Perdetzoglou, D., Loukis, A. Essential oils and hexane extracts from leaves and fruits of Cistus monspeliensis. Cytotoxic activity of ent-13-epi-manoyl oxide and its isomers . planta medica, 2001, vol. 67, no. 2, p. 168–171. DOI: 10.1055/s-2001-11497. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

labdane diterpenes (RF-00004392-PAR)
Additional substance description:

manoyl oxide and derivatives
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

15.38
Internal remarks:

Labdanes (Manoyl oxide and derivatives) - leaves essential oil

Composition #3: Angelopoulou, D., Demetzos, C., Dimas, C., Perdetzoglou, D., Loukis, A. Essential oils and hexane extracts from leaves and fruits of Cistus monspeliensis. Cytotoxic activity of ent-13-epi-manoyl oxide and its isomers . planta medica, 2001, vol. 67, no. 2, p. 168–171. DOI: 10.1055/s-2001-11497. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

clerodane-type diterpenes (RF-00004350-PAR)
Additional substance description:

cistodiol
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

6.6
Internal remarks:

Clerodanes (cistodiol) - fruit essential oil

Composition #4: Angelopoulou, D., Demetzos, C., Dimas, C., Perdetzoglou, D., Loukis, A. Essential oils and hexane extracts from leaves and fruits of Cistus monspeliensis. Cytotoxic activity of ent-13-epi-manoyl oxide and its isomers . planta medica, 2001, vol. 67, no. 2, p. 168–171. DOI: 10.1055/s-2001-11497. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane
Substance:

labdane diterpenes (RF-00004392-PAR)
Additional substance description:

manoyl oxide and derivatives
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

16.6
Internal remarks:

Labdanes (Manoyl oxide and derivatives) - leaves hexane extract

Composition #5: Angelopoulou, D., Demetzos, C., Dimas, C., Perdetzoglou, D., Loukis, A. Essential oils and hexane extracts from leaves and fruits of Cistus monspeliensis. Cytotoxic activity of ent-13-epi-manoyl oxide and its isomers . planta medica, 2001, vol. 67, no. 2, p. 168–171. DOI: 10.1055/s-2001-11497. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

labdane diterpenes (RF-00004392-PAR)
Additional substance description:

manoyl oxide and derivatives
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

6.6
Internal remarks:

Labdanes (Manoyl oxide and derivatives) - fruit essential oil

Composition #6: Angelopoulou, D., Demetzos, C., Dimas, C., Perdetzoglou, D., Loukis, A. Essential oils and hexane extracts from leaves and fruits of Cistus monspeliensis. Cytotoxic activity of ent-13-epi-manoyl oxide and its isomers . planta medica, 2001, vol. 67, no. 2, p. 168–171. DOI: 10.1055/s-2001-11497. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane
Substance:

clerodane-type diterpenes (RF-00004350-PAR)
Additional substance description:

cistodiol
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

62.5
Internal remarks:

Clerodanes (cistodiol) - fruit hexane extract

Composition #7: Angelopoulou, D., Demetzos, C., Dimas, C., Perdetzoglou, D., Loukis, A. Essential oils and hexane extracts from leaves and fruits of Cistus monspeliensis. Cytotoxic activity of ent-13-epi-manoyl oxide and its isomers . planta medica, 2001, vol. 67, no. 2, p. 168–171. DOI: 10.1055/s-2001-11497. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane
Substance:

clerodane-type diterpenes (RF-00004350-PAR)
Additional substance description:

cistodiol
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

50
Internal remarks:

Clerodanes (cistodiol) - leaves hexane extract

Composition #8: Fokialakis, Nikolas., Kalpoutzakis, Eleftherios., Tekwani, Babu Lal., Skaltsounis, Alexios Leandros., Duke, Stephen Oscar. Antileishmanial activity of natural diterpenes from Cistus sp and semisynthetic derivatives thereof. BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2006, vol. 29, no. 8, p. 1775–1778. DOI: 10.1248/bpb.29.1775. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CH2Cl2
Substance:

labdane diterpenes (RF-00004392-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

labdane diterpenes

Composition #9: Fokialakis, Nikolas., Kalpoutzakis, Eleftherios., Tekwani, Babu Lal., Skaltsounis, Alexios Leandros., Duke, Stephen Oscar. Antileishmanial activity of natural diterpenes from Cistus sp and semisynthetic derivatives thereof. BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2006, vol. 29, no. 8, p. 1775–1778. DOI: 10.1248/bpb.29.1775. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CH2Cl2
Substance:

clerodane-type diterpenes (RF-00004350-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

clerodane diterpenes

Composition #10: Santagati, Natale Alfredo., Salerno, Loredana., Attaguile, Giuseppina., Savoca, Francesca., Ronsisvalle, Giuseppe. Simultaneous determination of catechins, rutin, and gallic acid in Cistus species extracts by HPLC with diode array detection. JOURNAL OF CHROMATOGRAPHIC SCIENCE, 2008, vol. 46, no. 2, p. 150–156. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water
Substance:

gallic acid (RF-00003821-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

8.14
Internal remarks:

Gallic acid

Composition #11: Viuda-Martos, Manuel., Sendra, Esther., Perez-Alvarez, Jose A., Fernandez-Lopez, Juana., Amensour, Mahassine., Abrini, Jamal. Identification of Flavonoid Content and Chemical Composition of the Essential Oils of Moroccan Herbs: Myrtle (Myrtus communis L.), Rockrose (Cistus ladanifer L.) and Montpellier cistus (Cistus monspeliensis L.) . journal of essential oil research, 2011, vol. 23, no. 2, p. 1–9. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

8.8
Internal remarks:

1,8-cineole

Composition #12: Viuda-Martos, Manuel., Sendra, Esther., Perez-Alvarez, Jose A., Fernandez-Lopez, Juana., Amensour, Mahassine., Abrini, Jamal. Identification of Flavonoid Content and Chemical Composition of the Essential Oils of Moroccan Herbs: Myrtle (Myrtus communis L.), Rockrose (Cistus ladanifer L.) and Montpellier cistus (Cistus monspeliensis L.) . journal of essential oil research, 2011, vol. 23, no. 2, p. 1–9. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

(-)-camphor (RF-00003469-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.5
Internal remarks:

camphor

Composition #13: Viuda-Martos, Manuel., Sendra, Esther., Perez-Alvarez, Jose A., Fernandez-Lopez, Juana., Amensour, Mahassine., Abrini, Jamal. Identification of Flavonoid Content and Chemical Composition of the Essential Oils of Moroccan Herbs: Myrtle (Myrtus communis L.), Rockrose (Cistus ladanifer L.) and Montpellier cistus (Cistus monspeliensis L.) . journal of essential oil research, 2011, vol. 23, no. 2, p. 1–9. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

Eugenol (RF-00003807-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.5
Internal remarks:

eugenol