EFSA Compendium of Botanicals

Composition #1: Hui, Ruihua., Hou, Dongyan., Li, Tiechun., Guan, Chongxin. Analysis of volatile components in herb Cistanche. fenxi huaxue, 2003, p. 601–603. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Eugenol (RF-00003807-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

83.6
Internal remarks:

Eugenol

Endpoint study #1: Kim, San Woong., Yoo, Seung Hyeong., Lee, Hee Jae., Kim, Kyudam., Kim, Do Rim., Park, Seong Kyu., Chang, Mun Seog. Cistanches herba Induces Testis Cytotoxicity in Male Mice. bulletin of environmental contamination and toxicology, 2012, vol. 88, no. 1, p. 112–117. DOI: 10.1007/s00128-011-0428-3. [DOI link]

Study relevance:

Human health
Plant part:

Stem / stalk (as part-nature) (A067S)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

hot water extract
Type of toxicological test:

reproduction toxicity (CHD009TT)
Tested organism:

House mouse (as animal) (A0CNT)
Strain of test organism:

ICR (CHD044ST)
Sex:

Male
Route of exposure:

ORAL: DRINKING WATER (OECD2229PL)
Exposure duration:

35.0
Unit of exposure duration:

Day (G134A)
Control groups used:

yes, concurrent vehicle
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligram/kilogram (G061A)
Effect concentration:

500- 1000
Critical effect:

REPRODUCTIVE (TOX05A)
Target tissue:

urogenital: Testes (TT050A)
Effect description:

cytotoxicity in the male reproductive system, through the inhibition of spermatogenesis, testicular damage, and limited hormonal function
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

toxicity on male reproductive system

Cistanche deserticola Y.C.Ma